Towards a barrier-free anthropomorphic brain phantom for quantitative magnetic resonance imaging: Design, first construction attempt, and challenges
Existing magnetic resonance imaging (MRI) reference objects, or phantoms, are typically constructed from simple liquid or gel solutions in containers with specific geometric configurations to enable multi-year stability. However, there is a need for phantoms that better mimic the human anatomy witho...
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| Veröffentlicht in: | PloS one 2023-07, Vol.18 (7), p.e0285432-e0285432 |
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| creator | Kraft, Mikail Ryger, Slavka Berman, Ben P Downs, Matthew E Jordanova, Kalina V Poorman, Megan E Oberdick, Samuel D Ogier, Stephen E Russek, Stephen E Dagher, Joseph Keenan, Kathryn E |
| description | Existing magnetic resonance imaging (MRI) reference objects, or phantoms, are typically constructed from simple liquid or gel solutions in containers with specific geometric configurations to enable multi-year stability. However, there is a need for phantoms that better mimic the human anatomy without barriers between the tissues. Barriers result in regions without MRI signal between the different tissue mimics, which is an artificial image artifact. We created an anatomically representative 3D structure of the brain that mimicked the T1 and T2 relaxation properties of white and gray matter at 3 T. While the goal was to avoid barriers between tissues, the 3D printed barrier between white and gray matter and other flaws in the construction were visible at 3 T. Stability measurements were made using a portable MRI system operating at 64 mT, and T2 relaxation time was stable from 0 to 22 weeks. The phantom T1 relaxation properties did change from 0 to 10 weeks; however, they did not substantially change between 10 weeks and 22 weeks. The anthropomorphic phantom used a dissolvable mold construction method to better mimic anatomy, which worked in small test objects. The construction process, though, had many challenges. We share this work with the hope that the community can build on our experience. |
| doi_str_mv | 10.1371/journal.pone.0285432 |
| format | Article |
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However, there is a need for phantoms that better mimic the human anatomy without barriers between the tissues. Barriers result in regions without MRI signal between the different tissue mimics, which is an artificial image artifact. We created an anatomically representative 3D structure of the brain that mimicked the T1 and T2 relaxation properties of white and gray matter at 3 T. While the goal was to avoid barriers between tissues, the 3D printed barrier between white and gray matter and other flaws in the construction were visible at 3 T. Stability measurements were made using a portable MRI system operating at 64 mT, and T2 relaxation time was stable from 0 to 22 weeks. The phantom T1 relaxation properties did change from 0 to 10 weeks; however, they did not substantially change between 10 weeks and 22 weeks. The anthropomorphic phantom used a dissolvable mold construction method to better mimic anatomy, which worked in small test objects. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c576t-28fe717dff20bfb798b2ba80b6573bb2a0bbc3a322ebb2c2443684b734813c0e3</cites><orcidid>0000-0001-9070-5255 ; 0000-0003-2707-5945 ; 0000-0003-1098-1693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337967/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337967/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37437022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraft, Mikail</creatorcontrib><creatorcontrib>Ryger, Slavka</creatorcontrib><creatorcontrib>Berman, Ben P</creatorcontrib><creatorcontrib>Downs, Matthew E</creatorcontrib><creatorcontrib>Jordanova, Kalina V</creatorcontrib><creatorcontrib>Poorman, Megan E</creatorcontrib><creatorcontrib>Oberdick, Samuel D</creatorcontrib><creatorcontrib>Ogier, Stephen E</creatorcontrib><creatorcontrib>Russek, Stephen E</creatorcontrib><creatorcontrib>Dagher, Joseph</creatorcontrib><creatorcontrib>Keenan, Kathryn E</creatorcontrib><title>Towards a barrier-free anthropomorphic brain phantom for quantitative magnetic resonance imaging: Design, first construction attempt, and challenges</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Existing magnetic resonance imaging (MRI) reference objects, or phantoms, are typically constructed from simple liquid or gel solutions in containers with specific geometric configurations to enable multi-year stability. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Anatomy Anthropomorphism Biology and Life Sciences Brain Brain - diagnostic imaging Design Engineering and technology Evaluation Gray Matter - diagnostic imaging Human anatomy Humans Magnetic resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Medical imaging Medicine and Health Sciences Nanoparticles Neuroimaging Phantoms, Imaging Physical Sciences Polyvinyl alcohol Relaxation time Research and Analysis Methods Silicones Stability Substantia grisea Three dimensional printing Tissues |
| title | Towards a barrier-free anthropomorphic brain phantom for quantitative magnetic resonance imaging: Design, first construction attempt, and challenges |
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