Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis

Reprogramming metabolism is of great therapeutic interest for reducing morbidity and mortality during sepsis-induced critical illness. Disappointing results from randomized controlled trials targeting glutamine and antioxidant metabolism in patients with sepsis have begged a deeper understanding of...

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Veröffentlicht in:	PloS one 2023-07, Vol.18 (7), p.e0286525-e0286525
Hauptverfasser:	Leitner, Brooks P, Lee, Won D, Zhu, Wanling, Zhang, Xinyi, Gaspar, Rafael C, Li, Zongyu, Rabinowitz, Joshua D, Perry, Rachel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Antioxidants Biology and Life Sciences Biopsy Biosynthesis Care and treatment Chain branching Clinical trials Correlation Cytokines Diagnosis Electron transport Fatty acids Gene expression Glutamine Glutathione Health aspects Infection Inflammation Intensive care Kidneys Liver Mass spectrometry Medicine and Health Sciences Metabolic response Metabolism Metabolites Metabolomics Mitochondria Morbidity Mortality Muscles Musculoskeletal system Organs Oxidation Oxidative stress Patients Phenotyping Physical Sciences Physiological aspects Plasma Quadriceps muscle Scientific imaging Sepsis Skeletal muscle Spleen Tissues Transcriptomics Tricarboxylic acid cycle
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