Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment
Throughout the last years, the coronavirus disease 2019 (COVID-19) pandemic posed a major challenge to the optimal and timely treatment of neurooncological patients around the world. While the importance of prompt surgical treatment in high-grade gliomas is widely accepted, there is sparse data on t...
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| creator | Mischkulnig, Mario Hopp, Benjamin Wadiura, Lisa I Khalaveh, Farjad Kiesel, Barbara Rössler, Karl Widhalm, Georg Dorfer, Christian |
| description | Throughout the last years, the coronavirus disease 2019 (COVID-19) pandemic posed a major challenge to the optimal and timely treatment of neurooncological patients around the world. While the importance of prompt surgical treatment in high-grade gliomas is widely accepted, there is sparse data on the impact of the pandemic on patients suffering from this malignant disease.
We performed a retrospective analysis of patients undergoing surgical high-grade glioma treatment at the Medical University of Vienna between March 2020 and February 2021, as well as a control cohort of patients who received treatment between January and December 2019. Time lag between referral for surgical treatment to actual surgery, preoperative tumor volume and overall patient survival were compared between groups.
A total of 118 patients, including 62 cases treated during the first year of the COVID-19 pandemic, as well as 56 control patients, were investigated in this study. Median interval to surgery was significantly shorter in patients treated during COVID-19 compared with the control group (4.00 versus 7.00 days; p = 0.0005). In contrast, patients treated during COVID-19 exhibited marginally larger preoperative tumor volumes, while overall patient survival was comparable between groups.
The COVID-19 pandemic did not negatively affect the overall survival of patients undergoing surgical high-grade glioma treatment at our institution. The significantly shorter treatment delay in patients treated during the pandemic likely reflects increased resource allocation for this critical patient population. |
| doi_str_mv | 10.1371/journal.pone.0287993 |
| format | Article |
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We performed a retrospective analysis of patients undergoing surgical high-grade glioma treatment at the Medical University of Vienna between March 2020 and February 2021, as well as a control cohort of patients who received treatment between January and December 2019. Time lag between referral for surgical treatment to actual surgery, preoperative tumor volume and overall patient survival were compared between groups.
A total of 118 patients, including 62 cases treated during the first year of the COVID-19 pandemic, as well as 56 control patients, were investigated in this study. Median interval to surgery was significantly shorter in patients treated during COVID-19 compared with the control group (4.00 versus 7.00 days; p = 0.0005). In contrast, patients treated during COVID-19 exhibited marginally larger preoperative tumor volumes, while overall patient survival was comparable between groups.
The COVID-19 pandemic did not negatively affect the overall survival of patients undergoing surgical high-grade glioma treatment at our institution. The significantly shorter treatment delay in patients treated during the pandemic likely reflects increased resource allocation for this critical patient population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0287993</identifier><identifier>PMID: 37390078</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biopsy ; Brain cancer ; Care and treatment ; Coronaviruses ; COVID-19 ; Data collection ; Diagnosis ; Epidemics ; Glioma ; Gliomas ; Health services ; Magnetic resonance imaging ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Mortality ; Neurosurgery ; Normal distribution ; Pandemics ; Patient outcomes ; Patients ; Research and Analysis Methods ; Resource allocation ; Response time ; Software ; Surgery ; Survival ; Survival analysis ; Time lag ; Tumors ; Viral diseases ; Volumetric analysis</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0287993-e0287993</ispartof><rights>Copyright: © 2023 Mischkulnig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Mischkulnig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Mischkulnig et al 2023 Mischkulnig et al</rights><rights>2023 Mischkulnig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-87d82e7e38159d48f2b5ea7f43e273e49d49e5a5f36668f1d77bcd966b8668b93</citedby><cites>FETCH-LOGICAL-c693t-87d82e7e38159d48f2b5ea7f43e273e49d49e5a5f36668f1d77bcd966b8668b93</cites><orcidid>0000-0002-1843-7732 ; 0000-0001-5478-0792 ; 0000-0002-9227-461X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313013/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313013/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37390078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Burger, Michael C</contributor><creatorcontrib>Mischkulnig, Mario</creatorcontrib><creatorcontrib>Hopp, Benjamin</creatorcontrib><creatorcontrib>Wadiura, Lisa I</creatorcontrib><creatorcontrib>Khalaveh, Farjad</creatorcontrib><creatorcontrib>Kiesel, Barbara</creatorcontrib><creatorcontrib>Rössler, Karl</creatorcontrib><creatorcontrib>Widhalm, Georg</creatorcontrib><creatorcontrib>Dorfer, Christian</creatorcontrib><title>Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Throughout the last years, the coronavirus disease 2019 (COVID-19) pandemic posed a major challenge to the optimal and timely treatment of neurooncological patients around the world. While the importance of prompt surgical treatment in high-grade gliomas is widely accepted, there is sparse data on the impact of the pandemic on patients suffering from this malignant disease.
We performed a retrospective analysis of patients undergoing surgical high-grade glioma treatment at the Medical University of Vienna between March 2020 and February 2021, as well as a control cohort of patients who received treatment between January and December 2019. Time lag between referral for surgical treatment to actual surgery, preoperative tumor volume and overall patient survival were compared between groups.
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The COVID-19 pandemic did not negatively affect the overall survival of patients undergoing surgical high-grade glioma treatment at our institution. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-30</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0287993</spage><epage>e0287993</epage><pages>e0287993-e0287993</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Throughout the last years, the coronavirus disease 2019 (COVID-19) pandemic posed a major challenge to the optimal and timely treatment of neurooncological patients around the world. While the importance of prompt surgical treatment in high-grade gliomas is widely accepted, there is sparse data on the impact of the pandemic on patients suffering from this malignant disease.
We performed a retrospective analysis of patients undergoing surgical high-grade glioma treatment at the Medical University of Vienna between March 2020 and February 2021, as well as a control cohort of patients who received treatment between January and December 2019. Time lag between referral for surgical treatment to actual surgery, preoperative tumor volume and overall patient survival were compared between groups.
A total of 118 patients, including 62 cases treated during the first year of the COVID-19 pandemic, as well as 56 control patients, were investigated in this study. Median interval to surgery was significantly shorter in patients treated during COVID-19 compared with the control group (4.00 versus 7.00 days; p = 0.0005). In contrast, patients treated during COVID-19 exhibited marginally larger preoperative tumor volumes, while overall patient survival was comparable between groups.
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Biopsy Brain cancer Care and treatment Coronaviruses COVID-19 Data collection Diagnosis Epidemics Glioma Gliomas Health services Magnetic resonance imaging Medical prognosis Medical research Medicine and Health Sciences Medicine, Experimental Mortality Neurosurgery Normal distribution Pandemics Patient outcomes Patients Research and Analysis Methods Resource allocation Response time Software Surgery Survival Survival analysis Time lag Tumors Viral diseases Volumetric analysis |
| title | Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment |
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