Constructing of predictive model for the surgical effect of patients with cleft lip and palate
To explore effective factors of surgical effect for patients with cleft lip and palate, and to construct the predictive model of surgical effect, which provide reference for improving the effect of cleft lip and palate surgery. This study has been ethically reviewed and approved by the Medical Ethic...
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description | To explore effective factors of surgical effect for patients with cleft lip and palate, and to construct the predictive model of surgical effect, which provide reference for improving the effect of cleft lip and palate surgery.
This study has been ethically reviewed and approved by the Medical Ethics Committee of Guiyang Stomatological Hospital before the study began.A total of 997 cases of cleft lip and palate surgical treatment in Guiyang Stomatological Hospital from 2015 to 2020 were collected. Logistic regression analysis was used to analyze the factors influencing the surgical outcome, and a score system was established by assigning values to the influencing factors using the nomogram. Data of 110 patients were verified, and decision curve analysis was used to evaluate the predicted results.
Logistic regression analysis showed that the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition during pregnancy and labor intensity during pregnancy were independent risk factors for poor surgical results (all P |
doi_str_mv | 10.1371/journal.pone.0286976 |
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This study has been ethically reviewed and approved by the Medical Ethics Committee of Guiyang Stomatological Hospital before the study began.A total of 997 cases of cleft lip and palate surgical treatment in Guiyang Stomatological Hospital from 2015 to 2020 were collected. Logistic regression analysis was used to analyze the factors influencing the surgical outcome, and a score system was established by assigning values to the influencing factors using the nomogram. Data of 110 patients were verified, and decision curve analysis was used to evaluate the predicted results.
Logistic regression analysis showed that the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition during pregnancy and labor intensity during pregnancy were independent risk factors for poor surgical results (all P<0.05). The predictive model was built by including the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition and labor intensity during pregnancy into the predictive scoring system. The critical value was 273, the area under ROC curve (AUC) was 0.733(95%CI:0.704~0.76), the sensitivity was 89.57%, and the specificity was 48.14%.When the external validation data of 110 patients were brought into the score, the AUC of poor diagnostic value reached 74.5%, P<0.05, which was close to the modeling accuracy of 73.3%.
This study constructed a predictive model of surgical effect for patients with cleft lip and palate, which can be used for the clinical prediction of cleft lip and palate patients in Guizhou Province.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0286976</identifier><identifier>PMID: 37390058</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Birth defects ; Breast milk ; Breastfeeding & lactation ; Care and treatment ; Cleft lip ; Cleft lip/palate ; Cleft palate ; Decision analysis ; Diagnosis ; Ethics ; Hospitals ; Labor ; Medicine and Health Sciences ; Methods ; Model accuracy ; Modelling ; Multivariate analysis ; Nomograms ; Nomographs ; Nutrition ; Obstetrics ; Patients ; Physical Sciences ; Prediction models ; Pregnancy ; Regression analysis ; Research and Analysis Methods ; Risk factors ; Software ; Statistical analysis ; Surgery ; Surgical outcomes</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0286976-e0286976</ispartof><rights>Copyright: © 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Liu et al 2023 Liu et al</rights><rights>2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-80241d1feb863088551b98ae743d7908e3e195a0c65abaebbffb41ff394d58603</cites><orcidid>0000-0001-9808-4801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313050/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313050/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37390058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ashaat, Engy Asem</contributor><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Yang, Jingyuan</creatorcontrib><creatorcontrib>Tan, Fang</creatorcontrib><creatorcontrib>Zhu, Haijian</creatorcontrib><title>Constructing of predictive model for the surgical effect of patients with cleft lip and palate</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To explore effective factors of surgical effect for patients with cleft lip and palate, and to construct the predictive model of surgical effect, which provide reference for improving the effect of cleft lip and palate surgery.
This study has been ethically reviewed and approved by the Medical Ethics Committee of Guiyang Stomatological Hospital before the study began.A total of 997 cases of cleft lip and palate surgical treatment in Guiyang Stomatological Hospital from 2015 to 2020 were collected. Logistic regression analysis was used to analyze the factors influencing the surgical outcome, and a score system was established by assigning values to the influencing factors using the nomogram. Data of 110 patients were verified, and decision curve analysis was used to evaluate the predicted results.
Logistic regression analysis showed that the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition during pregnancy and labor intensity during pregnancy were independent risk factors for poor surgical results (all P<0.05). The predictive model was built by including the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition and labor intensity during pregnancy into the predictive scoring system. The critical value was 273, the area under ROC curve (AUC) was 0.733(95%CI:0.704~0.76), the sensitivity was 89.57%, and the specificity was 48.14%.When the external validation data of 110 patients were brought into the score, the AUC of poor diagnostic value reached 74.5%, P<0.05, which was close to the modeling accuracy of 73.3%.
This study constructed a predictive model of surgical effect for patients with cleft lip and palate, which can be used for the clinical prediction of cleft lip and palate patients in Guizhou Province.</description><subject>Biology and Life Sciences</subject><subject>Birth defects</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Care and treatment</subject><subject>Cleft lip</subject><subject>Cleft lip/palate</subject><subject>Cleft palate</subject><subject>Decision analysis</subject><subject>Diagnosis</subject><subject>Ethics</subject><subject>Hospitals</subject><subject>Labor</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Model accuracy</subject><subject>Modelling</subject><subject>Multivariate analysis</subject><subject>Nomograms</subject><subject>Nomographs</subject><subject>Nutrition</subject><subject>Obstetrics</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prediction models</subject><subject>Pregnancy</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Surgical 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of predictive model for the surgical effect of patients with cleft lip and palate</title><author>Liu, Na ; Yang, Jingyuan ; Tan, Fang ; Zhu, Haijian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-80241d1feb863088551b98ae743d7908e3e195a0c65abaebbffb41ff394d58603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biology and Life Sciences</topic><topic>Birth defects</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Care and treatment</topic><topic>Cleft lip</topic><topic>Cleft lip/palate</topic><topic>Cleft palate</topic><topic>Decision analysis</topic><topic>Diagnosis</topic><topic>Ethics</topic><topic>Hospitals</topic><topic>Labor</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Model accuracy</topic><topic>Modelling</topic><topic>Multivariate analysis</topic><topic>Nomograms</topic><topic>Nomographs</topic><topic>Nutrition</topic><topic>Obstetrics</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Prediction models</topic><topic>Pregnancy</topic><topic>Regression analysis</topic><topic>Research and Analysis Methods</topic><topic>Risk factors</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Yang, Jingyuan</creatorcontrib><creatorcontrib>Tan, Fang</creatorcontrib><creatorcontrib>Zhu, Haijian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context: Opposing Viewpoints</collection><collection>Gale in Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts 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titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Na</au><au>Yang, Jingyuan</au><au>Tan, Fang</au><au>Zhu, Haijian</au><au>Ashaat, Engy Asem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Constructing of predictive model for the surgical effect of patients with cleft lip and palate</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-30</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0286976</spage><epage>e0286976</epage><pages>e0286976-e0286976</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To explore effective factors of surgical effect for patients with cleft lip and palate, and to construct the predictive model of surgical effect, which provide reference for improving the effect of cleft lip and palate surgery.
This study has been ethically reviewed and approved by the Medical Ethics Committee of Guiyang Stomatological Hospital before the study began.A total of 997 cases of cleft lip and palate surgical treatment in Guiyang Stomatological Hospital from 2015 to 2020 were collected. Logistic regression analysis was used to analyze the factors influencing the surgical outcome, and a score system was established by assigning values to the influencing factors using the nomogram. Data of 110 patients were verified, and decision curve analysis was used to evaluate the predicted results.
Logistic regression analysis showed that the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition during pregnancy and labor intensity during pregnancy were independent risk factors for poor surgical results (all P<0.05). The predictive model was built by including the number of surgeries, surgical methods, breast milk, prenatal examination, nutrition and labor intensity during pregnancy into the predictive scoring system. The critical value was 273, the area under ROC curve (AUC) was 0.733(95%CI:0.704~0.76), the sensitivity was 89.57%, and the specificity was 48.14%.When the external validation data of 110 patients were brought into the score, the AUC of poor diagnostic value reached 74.5%, P<0.05, which was close to the modeling accuracy of 73.3%.
This study constructed a predictive model of surgical effect for patients with cleft lip and palate, which can be used for the clinical prediction of cleft lip and palate patients in Guizhou Province.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37390058</pmid><doi>10.1371/journal.pone.0286976</doi><tpages>e0286976</tpages><orcidid>https://orcid.org/0000-0001-9808-4801</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biology and Life Sciences Birth defects Breast milk Breastfeeding & lactation Care and treatment Cleft lip Cleft lip/palate Cleft palate Decision analysis Diagnosis Ethics Hospitals Labor Medicine and Health Sciences Methods Model accuracy Modelling Multivariate analysis Nomograms Nomographs Nutrition Obstetrics Patients Physical Sciences Prediction models Pregnancy Regression analysis Research and Analysis Methods Risk factors Software Statistical analysis Surgery Surgical outcomes |
title | Constructing of predictive model for the surgical effect of patients with cleft lip and palate |
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