Impact of timing and severity of COVID-19 infection in pregnancy on intrauterine fetal growth- a registry-based study from Qatar
The novel coronavirus disease (COVID-19) pandemic has impacted pregnant women, increasing maternal and neonatal morbidity. The placenta is a potential target for the pathophysiological processes due to the increased thrombotic inflammatory activation and inadequate uteroplacental perfusion and oxyge...
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| Veröffentlicht in: | PloS one 2023-06, Vol.18 (6), p.e0288004-e0288004 |
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| creator | Farrell, Thomas Minisha, Fathima Abu Yaqoub, Salwa Rahim, Abubaker Abdel Omar, Mai Ahmed, Huda Lindow, Stephen Abraham, Merlin Rajam Gassim, Mahmoud Al-Dewik, Nader Ahmed, Shamsa Al-Rifai, Hilal |
| description | The novel coronavirus disease (COVID-19) pandemic has impacted pregnant women, increasing maternal and neonatal morbidity. The placenta is a potential target for the pathophysiological processes due to the increased thrombotic inflammatory activation and inadequate uteroplacental perfusion and oxygenation, potentially causing intrauterine growth restriction. This study investigates the impact of gestational age at diagnosis of COVID-19 and the presence of symptoms on intrauterine fetal growth in pregnant women.
A retrospective review of COVID-19 positive pregnant women in Qatar from March 2020 to March 2021 was conducted. They were divided based on trimester of pregnancy in which they were infected. The outcomes included birthweight, customised fetal birthweight centiles, small for gestational age (SGA) baby and daily growth increments, compared between the trimesters and between symptomatic and asymptomatic women.
In our cohort, 218 women (20.5%) were infected in the first trimester, 399 (37.5%) in the second and 446 (42%) in the third. Women in the second trimester were significantly younger and symptomatic. Women infected in the first trimester were least likely to have diabetes. The mean birthweight, risk of SGA (11.5% vs 10% vs 14.6%, p = 0.302), and median customized growth centiles (47.6% vs 45.9% vs 46.1%)were similar between the groups. Symptomatic women had significantly lower mean birthweight (3147 gms vs 3222 gms) and median birthweight centiles (43.9% vs 54.0%)compared to the asymptomatic (p |
| doi_str_mv | 10.1371/journal.pone.0288004 |
| format | Article |
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A retrospective review of COVID-19 positive pregnant women in Qatar from March 2020 to March 2021 was conducted. They were divided based on trimester of pregnancy in which they were infected. The outcomes included birthweight, customised fetal birthweight centiles, small for gestational age (SGA) baby and daily growth increments, compared between the trimesters and between symptomatic and asymptomatic women.
In our cohort, 218 women (20.5%) were infected in the first trimester, 399 (37.5%) in the second and 446 (42%) in the third. Women in the second trimester were significantly younger and symptomatic. Women infected in the first trimester were least likely to have diabetes. The mean birthweight, risk of SGA (11.5% vs 10% vs 14.6%, p = 0.302), and median customized growth centiles (47.6% vs 45.9% vs 46.1%)were similar between the groups. Symptomatic women had significantly lower mean birthweight (3147 gms vs 3222 gms) and median birthweight centiles (43.9% vs 54.0%)compared to the asymptomatic (p<0.05 for both). In women infected within 20 weeks of gestation, a delay in daily fetal growth increments was noted with symptomatic disease, although not statistically significant.
This study shows that women with symptomatic disease had lower birth centiles and birth weights. This was regardless of the gestational age at which they were infected. Early symptomatic disease seems to have an impact on fetal growth velocity; however, larger studies are needed to corroborate these findings.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0288004</identifier><identifier>PMID: 37390057</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Angiogenesis ; Asymptomatic ; Biology and Life Sciences ; Birth weight ; Coronaviruses ; COVID-19 ; Customization ; Diabetes ; Diabetes mellitus ; Disease transmission ; Epidemics ; Fetus ; Fetuses ; Gestational age ; Growth ; Health aspects ; Health risks ; Hospitals ; Hypertension ; Infections ; Inflammation ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Morbidity ; Mothers ; Neonates ; Oxygenation ; Pandemics ; Patient outcomes ; Placenta ; Pregnancy ; Pregnant women ; Premature birth ; Qatar ; Signs and symptoms ; Small for gestational age ; Statistical analysis ; Ultrasonic imaging ; Variables ; Velocity ; Viral diseases ; Womens health</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0288004-e0288004</ispartof><rights>Copyright: © 2023 Farrell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Farrell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Farrell et al 2023 Farrell et al</rights><rights>2023 Farrell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-eb3e0b3bcd814cf30de580e38d1b99b80736437787f626af71adacfd078d7a593</citedby><cites>FETCH-LOGICAL-c693t-eb3e0b3bcd814cf30de580e38d1b99b80736437787f626af71adacfd078d7a593</cites><orcidid>0000-0001-6903-5445 ; 0000-0003-2871-2248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313033/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313033/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37390057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Petry, Clive J.</contributor><creatorcontrib>Farrell, Thomas</creatorcontrib><creatorcontrib>Minisha, Fathima</creatorcontrib><creatorcontrib>Abu Yaqoub, Salwa</creatorcontrib><creatorcontrib>Rahim, Abubaker Abdel</creatorcontrib><creatorcontrib>Omar, Mai</creatorcontrib><creatorcontrib>Ahmed, Huda</creatorcontrib><creatorcontrib>Lindow, Stephen</creatorcontrib><creatorcontrib>Abraham, Merlin Rajam</creatorcontrib><creatorcontrib>Gassim, Mahmoud</creatorcontrib><creatorcontrib>Al-Dewik, Nader</creatorcontrib><creatorcontrib>Ahmed, Shamsa</creatorcontrib><creatorcontrib>Al-Rifai, Hilal</creatorcontrib><creatorcontrib>Q-precious group</creatorcontrib><title>Impact of timing and severity of COVID-19 infection in pregnancy on intrauterine fetal growth- a registry-based study from Qatar</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The novel coronavirus disease (COVID-19) pandemic has impacted pregnant women, increasing maternal and neonatal morbidity. The placenta is a potential target for the pathophysiological processes due to the increased thrombotic inflammatory activation and inadequate uteroplacental perfusion and oxygenation, potentially causing intrauterine growth restriction. This study investigates the impact of gestational age at diagnosis of COVID-19 and the presence of symptoms on intrauterine fetal growth in pregnant women.
A retrospective review of COVID-19 positive pregnant women in Qatar from March 2020 to March 2021 was conducted. They were divided based on trimester of pregnancy in which they were infected. The outcomes included birthweight, customised fetal birthweight centiles, small for gestational age (SGA) baby and daily growth increments, compared between the trimesters and between symptomatic and asymptomatic women.
In our cohort, 218 women (20.5%) were infected in the first trimester, 399 (37.5%) in the second and 446 (42%) in the third. Women in the second trimester were significantly younger and symptomatic. Women infected in the first trimester were least likely to have diabetes. The mean birthweight, risk of SGA (11.5% vs 10% vs 14.6%, p = 0.302), and median customized growth centiles (47.6% vs 45.9% vs 46.1%)were similar between the groups. Symptomatic women had significantly lower mean birthweight (3147 gms vs 3222 gms) and median birthweight centiles (43.9% vs 54.0%)compared to the asymptomatic (p<0.05 for both). In women infected within 20 weeks of gestation, a delay in daily fetal growth increments was noted with symptomatic disease, although not statistically significant.
This study shows that women with symptomatic disease had lower birth centiles and birth weights. This was regardless of the gestational age at which they were infected. Early symptomatic disease seems to have an impact on fetal growth velocity; however, larger studies are needed to corroborate these findings.</description><subject>Age</subject><subject>Angiogenesis</subject><subject>Asymptomatic</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Customization</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Fetus</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, 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of timing and severity of COVID-19 infection in pregnancy on intrauterine fetal growth- a registry-based study from Qatar</title><author>Farrell, Thomas ; Minisha, Fathima ; Abu Yaqoub, Salwa ; Rahim, Abubaker Abdel ; Omar, Mai ; Ahmed, Huda ; Lindow, Stephen ; Abraham, Merlin Rajam ; Gassim, Mahmoud ; Al-Dewik, Nader ; Ahmed, Shamsa ; Al-Rifai, Hilal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-eb3e0b3bcd814cf30de580e38d1b99b80736437787f626af71adacfd078d7a593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Angiogenesis</topic><topic>Asymptomatic</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Customization</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Disease 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One</addtitle><date>2023-06-30</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0288004</spage><epage>e0288004</epage><pages>e0288004-e0288004</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The novel coronavirus disease (COVID-19) pandemic has impacted pregnant women, increasing maternal and neonatal morbidity. The placenta is a potential target for the pathophysiological processes due to the increased thrombotic inflammatory activation and inadequate uteroplacental perfusion and oxygenation, potentially causing intrauterine growth restriction. This study investigates the impact of gestational age at diagnosis of COVID-19 and the presence of symptoms on intrauterine fetal growth in pregnant women.
A retrospective review of COVID-19 positive pregnant women in Qatar from March 2020 to March 2021 was conducted. They were divided based on trimester of pregnancy in which they were infected. The outcomes included birthweight, customised fetal birthweight centiles, small for gestational age (SGA) baby and daily growth increments, compared between the trimesters and between symptomatic and asymptomatic women.
In our cohort, 218 women (20.5%) were infected in the first trimester, 399 (37.5%) in the second and 446 (42%) in the third. Women in the second trimester were significantly younger and symptomatic. Women infected in the first trimester were least likely to have diabetes. The mean birthweight, risk of SGA (11.5% vs 10% vs 14.6%, p = 0.302), and median customized growth centiles (47.6% vs 45.9% vs 46.1%)were similar between the groups. Symptomatic women had significantly lower mean birthweight (3147 gms vs 3222 gms) and median birthweight centiles (43.9% vs 54.0%)compared to the asymptomatic (p<0.05 for both). In women infected within 20 weeks of gestation, a delay in daily fetal growth increments was noted with symptomatic disease, although not statistically significant.
This study shows that women with symptomatic disease had lower birth centiles and birth weights. This was regardless of the gestational age at which they were infected. Early symptomatic disease seems to have an impact on fetal growth velocity; however, larger studies are needed to corroborate these findings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37390057</pmid><doi>10.1371/journal.pone.0288004</doi><orcidid>https://orcid.org/0000-0001-6903-5445</orcidid><orcidid>https://orcid.org/0000-0003-2871-2248</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-06, Vol.18 (6), p.e0288004-e0288004 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2831772846 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Age Angiogenesis Asymptomatic Biology and Life Sciences Birth weight Coronaviruses COVID-19 Customization Diabetes Diabetes mellitus Disease transmission Epidemics Fetus Fetuses Gestational age Growth Health aspects Health risks Hospitals Hypertension Infections Inflammation Medical research Medicine and Health Sciences Medicine, Experimental Morbidity Mothers Neonates Oxygenation Pandemics Patient outcomes Placenta Pregnancy Pregnant women Premature birth Qatar Signs and symptoms Small for gestational age Statistical analysis Ultrasonic imaging Variables Velocity Viral diseases Womens health |
| title | Impact of timing and severity of COVID-19 infection in pregnancy on intrauterine fetal growth- a registry-based study from Qatar |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T19%3A04%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20timing%20and%20severity%20of%20COVID-19%20infection%20in%20pregnancy%20on%20intrauterine%20fetal%20growth-%20a%20registry-based%20study%20from%20Qatar&rft.jtitle=PloS%20one&rft.au=Farrell,%20Thomas&rft.aucorp=Q-precious%20group&rft.date=2023-06-30&rft.volume=18&rft.issue=6&rft.spage=e0288004&rft.epage=e0288004&rft.pages=e0288004-e0288004&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0288004&rft_dat=%3Cgale_plos_%3EA755350382%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2831772846&rft_id=info:pmid/37390057&rft_galeid=A755350382&rft_doaj_id=oai_doaj_org_article_d03d554de4e94fd189151b1dd5129449&rfr_iscdi=true |