Fractal dimension analysis of different mandibular regions in familial Mediterranean fever patients: A cross-sectional retrospective study
Familial Mediterranean fever (FMF) is a genetic condition that may cause loss of bone mineral density (BMD) due to chronic inflammation. Previously, fractal dimension (FD) analysis values of mandibular cortical bone were shown to be lower in osteoporosis. Therefore, FD might be considered as an auxi...
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| description | Familial Mediterranean fever (FMF) is a genetic condition that may cause loss of bone mineral density (BMD) due to chronic inflammation. Previously, fractal dimension (FD) analysis values of mandibular cortical bone were shown to be lower in osteoporosis. Therefore, FD might be considered as an auxiliary tool to refer patients for dual-energy x-ray absorptiometry (DXA), which is the gold standard for BMD measurement. The purpose of this cross-sectional retrospective study was to evaluate trabecular and cortical microarchitecture of the mandible with FD analysis on panoramic radiographs in a subpopulation of FMF. Also, the effect of colchicine use was investigated. Forty-three FMF patients, aged between 10.8 and 71.2 years, and age- and gender-matched control group consisting of patients, who had no systemic diseases, were included. Demographic information such as age and gender, and colchicine use were recorded. In terms of age, the patients were classified as |
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Previously, fractal dimension (FD) analysis values of mandibular cortical bone were shown to be lower in osteoporosis. Therefore, FD might be considered as an auxiliary tool to refer patients for dual-energy x-ray absorptiometry (DXA), which is the gold standard for BMD measurement. The purpose of this cross-sectional retrospective study was to evaluate trabecular and cortical microarchitecture of the mandible with FD analysis on panoramic radiographs in a subpopulation of FMF. Also, the effect of colchicine use was investigated. Forty-three FMF patients, aged between 10.8 and 71.2 years, and age- and gender-matched control group consisting of patients, who had no systemic diseases, were included. Demographic information such as age and gender, and colchicine use were recorded. In terms of age, the patients were classified as <30 and 30< years. On each panoramic radiographs five regions of interest were selected on the mandible as: 1- premolar, 2- molar, 3- angular, 4- condylar, and 5- basal cortical bone regions on right (R) and left (L) sides. Statistical significance was accepted at p<0.05 level. Intra- and inter-observer agreements demonstrated good to excellent consistency. In FMF patients, L3 and L4 values were higher, whereas L5 values were lower (p<0.05) than the control group. In terms of age, the difference between groups was insignificant in FMF patients (p>0.05), whereas in control group R3 and L4 values were higher in the 30< age group (p<0.05). Regarding gender and colchicine use, the difference between groups was insignificant (p>0.05). FMF disease might be a candidate for referral to DXA examination based on decreased bone density in the mandibular cortex detected by FD measurements on routine panoramic radiographs. Further studies are warranted to ascertain this relationship.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0288170</identifier><identifier>PMID: 37390096</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Biology and Life Sciences ; Bone density ; Bone mineral density ; Bones ; Colchicine ; Complications and side effects ; Computer architecture ; Cortical bone ; Density ; Dentistry ; Diagnosis ; Drug dosages ; Dual energy X-ray absorptiometry ; Familial Mediterranean fever ; FDA approval ; Fever ; Fractal analysis ; Fractal geometry ; Fractals ; Fractures ; Gender ; Genetic aspects ; Informed consent ; Mandible ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Metabolism ; Osteoporosis ; Patient outcomes ; Patients ; People and Places ; Physical Sciences ; Radiographs ; Radiography ; Research and Analysis Methods ; Risk factors ; Software ; Systemic diseases ; University faculty</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0288170-e0288170</ispartof><rights>Copyright: © 2023 Ersan, Özel. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Ersan, Özel. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Ersan, Özel 2023 Ersan, Özel</rights><rights>2023 Ersan, Özel. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Previously, fractal dimension (FD) analysis values of mandibular cortical bone were shown to be lower in osteoporosis. Therefore, FD might be considered as an auxiliary tool to refer patients for dual-energy x-ray absorptiometry (DXA), which is the gold standard for BMD measurement. The purpose of this cross-sectional retrospective study was to evaluate trabecular and cortical microarchitecture of the mandible with FD analysis on panoramic radiographs in a subpopulation of FMF. Also, the effect of colchicine use was investigated. Forty-three FMF patients, aged between 10.8 and 71.2 years, and age- and gender-matched control group consisting of patients, who had no systemic diseases, were included. Demographic information such as age and gender, and colchicine use were recorded. In terms of age, the patients were classified as <30 and 30< years. 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Further studies are warranted to ascertain this relationship.]]></description><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Bones</subject><subject>Colchicine</subject><subject>Complications and side effects</subject><subject>Computer architecture</subject><subject>Cortical bone</subject><subject>Density</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Drug dosages</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Familial Mediterranean fever</subject><subject>FDA approval</subject><subject>Fever</subject><subject>Fractal analysis</subject><subject>Fractal geometry</subject><subject>Fractals</subject><subject>Fractures</subject><subject>Gender</subject><subject>Genetic aspects</subject><subject>Informed consent</subject><subject>Mandible</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, 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dimension analysis of different mandibular regions in familial Mediterranean fever patients: A cross-sectional retrospective study</title><author>Ersan, Nilüfer ; Özel, Beliz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-619fc67bdd2296d4fa71613a61a64bca8d9fc7aa9aca9c40f6878730cc24be03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Biology and Life Sciences</topic><topic>Bone density</topic><topic>Bone mineral density</topic><topic>Bones</topic><topic>Colchicine</topic><topic>Complications and side effects</topic><topic>Computer architecture</topic><topic>Cortical bone</topic><topic>Density</topic><topic>Dentistry</topic><topic>Diagnosis</topic><topic>Drug dosages</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Familial Mediterranean fever</topic><topic>FDA approval</topic><topic>Fever</topic><topic>Fractal 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One</addtitle><date>2023-06-30</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0288170</spage><epage>e0288170</epage><pages>e0288170-e0288170</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Familial Mediterranean fever (FMF) is a genetic condition that may cause loss of bone mineral density (BMD) due to chronic inflammation. Previously, fractal dimension (FD) analysis values of mandibular cortical bone were shown to be lower in osteoporosis. Therefore, FD might be considered as an auxiliary tool to refer patients for dual-energy x-ray absorptiometry (DXA), which is the gold standard for BMD measurement. The purpose of this cross-sectional retrospective study was to evaluate trabecular and cortical microarchitecture of the mandible with FD analysis on panoramic radiographs in a subpopulation of FMF. Also, the effect of colchicine use was investigated. Forty-three FMF patients, aged between 10.8 and 71.2 years, and age- and gender-matched control group consisting of patients, who had no systemic diseases, were included. Demographic information such as age and gender, and colchicine use were recorded. In terms of age, the patients were classified as <30 and 30< years. On each panoramic radiographs five regions of interest were selected on the mandible as: 1- premolar, 2- molar, 3- angular, 4- condylar, and 5- basal cortical bone regions on right (R) and left (L) sides. Statistical significance was accepted at p<0.05 level. Intra- and inter-observer agreements demonstrated good to excellent consistency. In FMF patients, L3 and L4 values were higher, whereas L5 values were lower (p<0.05) than the control group. In terms of age, the difference between groups was insignificant in FMF patients (p>0.05), whereas in control group R3 and L4 values were higher in the 30< age group (p<0.05). Regarding gender and colchicine use, the difference between groups was insignificant (p>0.05). FMF disease might be a candidate for referral to DXA examination based on decreased bone density in the mandibular cortex detected by FD measurements on routine panoramic radiographs. Further studies are warranted to ascertain this relationship.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37390096</pmid><doi>10.1371/journal.pone.0288170</doi><tpages>e0288170</tpages><orcidid>https://orcid.org/0000-0001-7039-7099</orcidid><orcidid>https://orcid.org/0000-0002-4917-6176</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Biology and Life Sciences Bone density Bone mineral density Bones Colchicine Complications and side effects Computer architecture Cortical bone Density Dentistry Diagnosis Drug dosages Dual energy X-ray absorptiometry Familial Mediterranean fever FDA approval Fever Fractal analysis Fractal geometry Fractals Fractures Gender Genetic aspects Informed consent Mandible Medical research Medicine and Health Sciences Medicine, Experimental Metabolism Osteoporosis Patient outcomes Patients People and Places Physical Sciences Radiographs Radiography Research and Analysis Methods Risk factors Software Systemic diseases University faculty |
| title | Fractal dimension analysis of different mandibular regions in familial Mediterranean fever patients: A cross-sectional retrospective study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A48%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fractal%20dimension%20analysis%20of%20different%20mandibular%20regions%20in%20familial%20Mediterranean%20fever%20patients:%20A%20cross-sectional%20retrospective%20study&rft.jtitle=PloS%20one&rft.au=Ersan,%20Nil%C3%BCfer&rft.date=2023-06-30&rft.volume=18&rft.issue=6&rft.spage=e0288170&rft.epage=e0288170&rft.pages=e0288170-e0288170&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0288170&rft_dat=%3Cgale_plos_%3EA755350381%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2831772673&rft_id=info:pmid/37390096&rft_galeid=A755350381&rft_doaj_id=oai_doaj_org_article_c4f3190132ba41eaae3319a79b2d4c6a&rfr_iscdi=true |