Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study
Coffee is the most commonly consumed beverage among children and adolescences. Caffeine was demonstrated to be associated with bone metabolism. However, the relationship between caffeine intake and BMD in children and adolescents remains unclear. This study aimed to identified relationship between c...
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| description | Coffee is the most commonly consumed beverage among children and adolescences. Caffeine was demonstrated to be associated with bone metabolism. However, the relationship between caffeine intake and BMD in children and adolescents remains unclear. This study aimed to identified relationship between caffeine consumption and bone mineral density (BMD) in children and adolescents.
Based on National Health and Nutrition Examination Survey (NHANES), we conducted an epidemiological cross-section study to measure the relationship between caffeine consumption and BMD in children and adolescents by multivariate linear regression models. Then, five methods of Mendelian randomization (MR) analyses were performed to estimate their causal relationship between coffee and caffeine intake and BMD in children and adolescents. MR-Egger and inverse-variance weighted (IVW) were used to evaluate the heterogeneity effect of instrumental variables (IVs).
In epidemiological studies, individuals with the highest quartile of caffeine intake do not have a significant change in femur neck BMD (β = 0.0016, 95% CI: -0.0096, 0.0129, P = 0.7747), total femur BMD (β = 0.0019, P = 0.7552), and total spine BMD (β = 0.0081, P = 0.1945) compared with the lowest quartile. In MR analysis, the IVW-random effect indicates no causal relationship between coffee consumption and TB- BMD (β = 0.0034, P = 0.0910). Other methods of MR analyses and sensitivity analysis reveals consistent findings. Similarly, the fixed-effects IVW method shows no causal association between caffeine intake and TB-BMD in children and adolescents (β = 0.0202, P = 0.7828).
Our study does not support a causal relationship between caffeine consumption and BMD in children and adolescents. However, more studies are needed to verify our findings, such as its underlying molecular mechanisms and the long-term impact of early caffeine exposure at a younger age. |
| doi_str_mv | 10.1371/journal.pone.0287756 |
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Based on National Health and Nutrition Examination Survey (NHANES), we conducted an epidemiological cross-section study to measure the relationship between caffeine consumption and BMD in children and adolescents by multivariate linear regression models. Then, five methods of Mendelian randomization (MR) analyses were performed to estimate their causal relationship between coffee and caffeine intake and BMD in children and adolescents. MR-Egger and inverse-variance weighted (IVW) were used to evaluate the heterogeneity effect of instrumental variables (IVs).
In epidemiological studies, individuals with the highest quartile of caffeine intake do not have a significant change in femur neck BMD (β = 0.0016, 95% CI: -0.0096, 0.0129, P = 0.7747), total femur BMD (β = 0.0019, P = 0.7552), and total spine BMD (β = 0.0081, P = 0.1945) compared with the lowest quartile. In MR analysis, the IVW-random effect indicates no causal relationship between coffee consumption and TB- BMD (β = 0.0034, P = 0.0910). Other methods of MR analyses and sensitivity analysis reveals consistent findings. Similarly, the fixed-effects IVW method shows no causal association between caffeine intake and TB-BMD in children and adolescents (β = 0.0202, P = 0.7828).
Our study does not support a causal relationship between caffeine consumption and BMD in children and adolescents. However, more studies are needed to verify our findings, such as its underlying molecular mechanisms and the long-term impact of early caffeine exposure at a younger age.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0287756</identifier><identifier>PMID: 37384670</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescents ; Age ; Biology and Life Sciences ; Bone density ; Bone mineral density ; Bone turnover ; Bones ; Caffeine ; Child development ; Children ; Coffee ; Consumption ; Cross-sectional studies ; Density ; Diagnosis ; Epidemiology ; Ethnicity ; Femur ; Fractures ; Genomes ; Health aspects ; Heterogeneity ; Hispanic people ; Medicine and Health Sciences ; Meta-analysis ; Metabolism ; Molecular modelling ; Nutrition ; Osteoporosis ; People and Places ; Physical Sciences ; Physiological aspects ; Randomization ; Regression analysis ; Regression models ; Review boards ; Risk factors ; Sensitivity analysis ; Software ; Spine ; Teenagers ; Variables</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0287756-e0287756</ispartof><rights>Copyright: © 2023 Cui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Cui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Cui et al 2023 Cui et al</rights><rights>2023 Cui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-fba5a4f8945eac0c94e2899e474f941cbd4f51575a4b7afbacce0cd19d401fcf3</cites><orcidid>0000-0002-2028-8270</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309635/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309635/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37384670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nkeck, Jan René</contributor><creatorcontrib>Cui, Aiyong</creatorcontrib><creatorcontrib>Xiao, Peilun</creatorcontrib><creatorcontrib>He, Jing</creatorcontrib><creatorcontrib>Fan, Zhiqiang</creatorcontrib><creatorcontrib>Xie, Mengli</creatorcontrib><creatorcontrib>Chen, Long</creatorcontrib><creatorcontrib>Zhuang, Yan</creatorcontrib><creatorcontrib>Wang, Hu</creatorcontrib><title>Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Coffee is the most commonly consumed beverage among children and adolescences. Caffeine was demonstrated to be associated with bone metabolism. However, the relationship between caffeine intake and BMD in children and adolescents remains unclear. This study aimed to identified relationship between caffeine consumption and bone mineral density (BMD) in children and adolescents.
Based on National Health and Nutrition Examination Survey (NHANES), we conducted an epidemiological cross-section study to measure the relationship between caffeine consumption and BMD in children and adolescents by multivariate linear regression models. Then, five methods of Mendelian randomization (MR) analyses were performed to estimate their causal relationship between coffee and caffeine intake and BMD in children and adolescents. MR-Egger and inverse-variance weighted (IVW) were used to evaluate the heterogeneity effect of instrumental variables (IVs).
In epidemiological studies, individuals with the highest quartile of caffeine intake do not have a significant change in femur neck BMD (β = 0.0016, 95% CI: -0.0096, 0.0129, P = 0.7747), total femur BMD (β = 0.0019, P = 0.7552), and total spine BMD (β = 0.0081, P = 0.1945) compared with the lowest quartile. In MR analysis, the IVW-random effect indicates no causal relationship between coffee consumption and TB- BMD (β = 0.0034, P = 0.0910). Other methods of MR analyses and sensitivity analysis reveals consistent findings. Similarly, the fixed-effects IVW method shows no causal association between caffeine intake and TB-BMD in children and adolescents (β = 0.0202, P = 0.7828).
Our study does not support a causal relationship between caffeine consumption and BMD in children and adolescents. However, more studies are needed to verify our findings, such as its underlying molecular mechanisms and the long-term impact of early caffeine exposure at a younger age.</description><subject>Adolescents</subject><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Bones</subject><subject>Caffeine</subject><subject>Child development</subject><subject>Children</subject><subject>Coffee</subject><subject>Consumption</subject><subject>Cross-sectional studies</subject><subject>Density</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Femur</subject><subject>Fractures</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Heterogeneity</subject><subject>Hispanic people</subject><subject>Medicine and Health 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between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study</title><author>Cui, Aiyong ; Xiao, Peilun ; He, Jing ; Fan, Zhiqiang ; Xie, Mengli ; Chen, Long ; Zhuang, Yan ; Wang, Hu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-fba5a4f8945eac0c94e2899e474f941cbd4f51575a4b7afbacce0cd19d401fcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescents</topic><topic>Age</topic><topic>Biology and Life Sciences</topic><topic>Bone density</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>Bones</topic><topic>Caffeine</topic><topic>Child development</topic><topic>Children</topic><topic>Coffee</topic><topic>Consumption</topic><topic>Cross-sectional 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Hu</au><au>Nkeck, Jan René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-29</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0287756</spage><epage>e0287756</epage><pages>e0287756-e0287756</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Coffee is the most commonly consumed beverage among children and adolescences. Caffeine was demonstrated to be associated with bone metabolism. However, the relationship between caffeine intake and BMD in children and adolescents remains unclear. This study aimed to identified relationship between caffeine consumption and bone mineral density (BMD) in children and adolescents.
Based on National Health and Nutrition Examination Survey (NHANES), we conducted an epidemiological cross-section study to measure the relationship between caffeine consumption and BMD in children and adolescents by multivariate linear regression models. Then, five methods of Mendelian randomization (MR) analyses were performed to estimate their causal relationship between coffee and caffeine intake and BMD in children and adolescents. MR-Egger and inverse-variance weighted (IVW) were used to evaluate the heterogeneity effect of instrumental variables (IVs).
In epidemiological studies, individuals with the highest quartile of caffeine intake do not have a significant change in femur neck BMD (β = 0.0016, 95% CI: -0.0096, 0.0129, P = 0.7747), total femur BMD (β = 0.0019, P = 0.7552), and total spine BMD (β = 0.0081, P = 0.1945) compared with the lowest quartile. In MR analysis, the IVW-random effect indicates no causal relationship between coffee consumption and TB- BMD (β = 0.0034, P = 0.0910). Other methods of MR analyses and sensitivity analysis reveals consistent findings. Similarly, the fixed-effects IVW method shows no causal association between caffeine intake and TB-BMD in children and adolescents (β = 0.0202, P = 0.7828).
Our study does not support a causal relationship between caffeine consumption and BMD in children and adolescents. However, more studies are needed to verify our findings, such as its underlying molecular mechanisms and the long-term impact of early caffeine exposure at a younger age.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37384670</pmid><doi>10.1371/journal.pone.0287756</doi><tpages>e0287756</tpages><orcidid>https://orcid.org/0000-0002-2028-8270</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescents Age Biology and Life Sciences Bone density Bone mineral density Bone turnover Bones Caffeine Child development Children Coffee Consumption Cross-sectional studies Density Diagnosis Epidemiology Ethnicity Femur Fractures Genomes Health aspects Heterogeneity Hispanic people Medicine and Health Sciences Meta-analysis Metabolism Molecular modelling Nutrition Osteoporosis People and Places Physical Sciences Physiological aspects Randomization Regression analysis Regression models Review boards Risk factors Sensitivity analysis Software Spine Teenagers Variables |
| title | Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T14%3A55%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20caffeine%20consumption%20and%20bone%20mineral%20density%20in%20children%20and%20adolescent:%20Observational%20and%20Mendelian%20randomization%20study&rft.jtitle=PloS%20one&rft.au=Cui,%20Aiyong&rft.date=2023-06-29&rft.volume=18&rft.issue=6&rft.spage=e0287756&rft.epage=e0287756&rft.pages=e0287756-e0287756&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0287756&rft_dat=%3Cgale_plos_%3EA755170216%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2831269684&rft_id=info:pmid/37384670&rft_galeid=A755170216&rft_doaj_id=oai_doaj_org_article_a696c14448554259802068a2c4740a8c&rfr_iscdi=true |