Feasibility and acceptability of an mHealth, home-based exercise intervention in colorectal cancer survivors: A pilot randomized controlled trial
To determine the feasibility and acceptability of an mHealth, home-based exercise intervention among stage II-III colorectal cancer (CRC) survivors within 5-years post-resection and adjuvant therapy. This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, rando...
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| Veröffentlicht in: | PloS one 2023-06, Vol.18 (6), p.e0287152 |
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| creator | Moraitis, Ann Marie Rose, Nathan B Johnson, Austin F Dunston, Emily R Garrido-Laguna, Ignacio Hobson, Paula Barber, Kristin Basen-Engquist, Karen Coletta, Adriana M |
| description | To determine the feasibility and acceptability of an mHealth, home-based exercise intervention among stage II-III colorectal cancer (CRC) survivors within 5-years post-resection and adjuvant therapy.
This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, randomly assigned CRC survivors to a high-intensity interval training (HIIT) or moderate-intensity continuous exercise (MICE) prescription. The following assessments were carried out at baseline and end-of-study (EOS): handgrip strength, short physical performance battery (SPPB), PROMIS physical function, neuropathy total symptom score-6 (NTSS-6), Utah early neuropathy scale (UENS), cardiopulmonary exercise testing, anthropometrics, and body composition via BOD POD, modified Godin leisure-time activity questionnaire. Feasibility, as defined by number of completed prescribed workouts and rate of adherence to individualized heart rate (HR) training zones, was evaluated at EOS. Acceptability was assessed by open-ended surveys at EOS. Descriptive statistics were generated for participant characteristics and assessment data.
Seven participants were included in this pilot study (MICE: n = 5, HIIT: n = 2). Median age was 39 years (1st quartile: 36, 3rd quartile: 50). BMI was 27.4 kg/m2 (1st quartile: 24.5, 3rd quartile: 29.7). Most participants had stage III CRC (71%, n = 5). We observed an 88.6% workout completion rate, 100% retention rate, no adverse events, and qualitative data indicating improved quality of life and positive feedback related to ease of use, accountability, motivation, and autonomy. Mean adherence to HR training zones was 95.7% in MICE, and 28.9% for the high-intensity intervals and 51.0% for the active recovery intervals in HIIT; qualitative results revealed that participants wanted to do more/work-out harder.
An mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors' post-resection and adjuvant therapy was tolerable and showed trends towards acceptability. |
| doi_str_mv | 10.1371/journal.pone.0287152 |
| format | Article |
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This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, randomly assigned CRC survivors to a high-intensity interval training (HIIT) or moderate-intensity continuous exercise (MICE) prescription. The following assessments were carried out at baseline and end-of-study (EOS): handgrip strength, short physical performance battery (SPPB), PROMIS physical function, neuropathy total symptom score-6 (NTSS-6), Utah early neuropathy scale (UENS), cardiopulmonary exercise testing, anthropometrics, and body composition via BOD POD, modified Godin leisure-time activity questionnaire. Feasibility, as defined by number of completed prescribed workouts and rate of adherence to individualized heart rate (HR) training zones, was evaluated at EOS. Acceptability was assessed by open-ended surveys at EOS. Descriptive statistics were generated for participant characteristics and assessment data.
Seven participants were included in this pilot study (MICE: n = 5, HIIT: n = 2). Median age was 39 years (1st quartile: 36, 3rd quartile: 50). BMI was 27.4 kg/m2 (1st quartile: 24.5, 3rd quartile: 29.7). Most participants had stage III CRC (71%, n = 5). We observed an 88.6% workout completion rate, 100% retention rate, no adverse events, and qualitative data indicating improved quality of life and positive feedback related to ease of use, accountability, motivation, and autonomy. Mean adherence to HR training zones was 95.7% in MICE, and 28.9% for the high-intensity intervals and 51.0% for the active recovery intervals in HIIT; qualitative results revealed that participants wanted to do more/work-out harder.
An mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors' post-resection and adjuvant therapy was tolerable and showed trends towards acceptability.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0287152</identifier><identifier>PMID: 37347792</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acceptability ; Adjuvant treatment ; Age ; Batteries ; Biology and Life Sciences ; Blood pressure ; Body composition ; Cancer ; Cancer survivors ; Care and treatment ; Chemotherapy ; Clinical trials ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - therapy ; Exercise ; Exercise therapy ; Exercise Therapy - methods ; Feasibility ; Feasibility Studies ; Hand Strength ; Heart beat ; Heart rate ; Home care ; Humans ; Interval training ; Intervals ; Intervention ; Kidney diseases ; Medical screening ; Medicine and Health Sciences ; Metabolism ; Methods ; Neuropathy ; Patient outcomes ; Physical fitness ; Physical training ; Pilot Projects ; Positive feedback ; Qualitative analysis ; Qualitative research ; Quality of Life ; Questionnaires ; Smartphones ; Survival ; Survivors ; Telemedicine ; Testing ; Training</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0287152</ispartof><rights>Copyright: © 2023 Moraitis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Moraitis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Moraitis et al 2023 Moraitis et al</rights><rights>2023 Moraitis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-8cf1d9b820aff7f63bc4598d1483e2b7e5bca01629dae04336149092cca44ff53</citedby><cites>FETCH-LOGICAL-c693t-8cf1d9b820aff7f63bc4598d1483e2b7e5bca01629dae04336149092cca44ff53</cites><orcidid>0000-0001-6684-9881 ; 0000-0002-2503-2792 ; 0000-0003-2482-0962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286977/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286977/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37347792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moraitis, Ann Marie</creatorcontrib><creatorcontrib>Rose, Nathan B</creatorcontrib><creatorcontrib>Johnson, Austin F</creatorcontrib><creatorcontrib>Dunston, Emily R</creatorcontrib><creatorcontrib>Garrido-Laguna, Ignacio</creatorcontrib><creatorcontrib>Hobson, Paula</creatorcontrib><creatorcontrib>Barber, Kristin</creatorcontrib><creatorcontrib>Basen-Engquist, Karen</creatorcontrib><creatorcontrib>Coletta, Adriana M</creatorcontrib><title>Feasibility and acceptability of an mHealth, home-based exercise intervention in colorectal cancer survivors: A pilot randomized controlled trial</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine the feasibility and acceptability of an mHealth, home-based exercise intervention among stage II-III colorectal cancer (CRC) survivors within 5-years post-resection and adjuvant therapy.
This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, randomly assigned CRC survivors to a high-intensity interval training (HIIT) or moderate-intensity continuous exercise (MICE) prescription. The following assessments were carried out at baseline and end-of-study (EOS): handgrip strength, short physical performance battery (SPPB), PROMIS physical function, neuropathy total symptom score-6 (NTSS-6), Utah early neuropathy scale (UENS), cardiopulmonary exercise testing, anthropometrics, and body composition via BOD POD, modified Godin leisure-time activity questionnaire. Feasibility, as defined by number of completed prescribed workouts and rate of adherence to individualized heart rate (HR) training zones, was evaluated at EOS. Acceptability was assessed by open-ended surveys at EOS. Descriptive statistics were generated for participant characteristics and assessment data.
Seven participants were included in this pilot study (MICE: n = 5, HIIT: n = 2). Median age was 39 years (1st quartile: 36, 3rd quartile: 50). BMI was 27.4 kg/m2 (1st quartile: 24.5, 3rd quartile: 29.7). Most participants had stage III CRC (71%, n = 5). We observed an 88.6% workout completion rate, 100% retention rate, no adverse events, and qualitative data indicating improved quality of life and positive feedback related to ease of use, accountability, motivation, and autonomy. Mean adherence to HR training zones was 95.7% in MICE, and 28.9% for the high-intensity intervals and 51.0% for the active recovery intervals in HIIT; qualitative results revealed that participants wanted to do more/work-out harder.
An mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors' post-resection and adjuvant therapy was tolerable and showed trends towards acceptability.</description><subject>Acceptability</subject><subject>Adjuvant treatment</subject><subject>Age</subject><subject>Batteries</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Body composition</subject><subject>Cancer</subject><subject>Cancer survivors</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Exercise</subject><subject>Exercise therapy</subject><subject>Exercise Therapy - methods</subject><subject>Feasibility</subject><subject>Feasibility Studies</subject><subject>Hand Strength</subject><subject>Heart beat</subject><subject>Heart rate</subject><subject>Home care</subject><subject>Humans</subject><subject>Interval training</subject><subject>Intervals</subject><subject>Intervention</subject><subject>Kidney diseases</subject><subject>Medical screening</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Neuropathy</subject><subject>Patient outcomes</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Pilot Projects</subject><subject>Positive feedback</subject><subject>Qualitative analysis</subject><subject>Qualitative research</subject><subject>Quality of 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survivors: A pilot randomized controlled trial</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-22</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0287152</spage><pages>e0287152-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine the feasibility and acceptability of an mHealth, home-based exercise intervention among stage II-III colorectal cancer (CRC) survivors within 5-years post-resection and adjuvant therapy.
This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, randomly assigned CRC survivors to a high-intensity interval training (HIIT) or moderate-intensity continuous exercise (MICE) prescription. The following assessments were carried out at baseline and end-of-study (EOS): handgrip strength, short physical performance battery (SPPB), PROMIS physical function, neuropathy total symptom score-6 (NTSS-6), Utah early neuropathy scale (UENS), cardiopulmonary exercise testing, anthropometrics, and body composition via BOD POD, modified Godin leisure-time activity questionnaire. Feasibility, as defined by number of completed prescribed workouts and rate of adherence to individualized heart rate (HR) training zones, was evaluated at EOS. Acceptability was assessed by open-ended surveys at EOS. Descriptive statistics were generated for participant characteristics and assessment data.
Seven participants were included in this pilot study (MICE: n = 5, HIIT: n = 2). Median age was 39 years (1st quartile: 36, 3rd quartile: 50). BMI was 27.4 kg/m2 (1st quartile: 24.5, 3rd quartile: 29.7). Most participants had stage III CRC (71%, n = 5). We observed an 88.6% workout completion rate, 100% retention rate, no adverse events, and qualitative data indicating improved quality of life and positive feedback related to ease of use, accountability, motivation, and autonomy. Mean adherence to HR training zones was 95.7% in MICE, and 28.9% for the high-intensity intervals and 51.0% for the active recovery intervals in HIIT; qualitative results revealed that participants wanted to do more/work-out harder.
An mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors' post-resection and adjuvant therapy was tolerable and showed trends towards acceptability.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37347792</pmid><doi>10.1371/journal.pone.0287152</doi><tpages>e0287152</tpages><orcidid>https://orcid.org/0000-0001-6684-9881</orcidid><orcidid>https://orcid.org/0000-0002-2503-2792</orcidid><orcidid>https://orcid.org/0000-0003-2482-0962</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-06, Vol.18 (6), p.e0287152 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2828662101 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acceptability Adjuvant treatment Age Batteries Biology and Life Sciences Blood pressure Body composition Cancer Cancer survivors Care and treatment Chemotherapy Clinical trials Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - therapy Exercise Exercise therapy Exercise Therapy - methods Feasibility Feasibility Studies Hand Strength Heart beat Heart rate Home care Humans Interval training Intervals Intervention Kidney diseases Medical screening Medicine and Health Sciences Metabolism Methods Neuropathy Patient outcomes Physical fitness Physical training Pilot Projects Positive feedback Qualitative analysis Qualitative research Quality of Life Questionnaires Smartphones Survival Survivors Telemedicine Testing Training |
| title | Feasibility and acceptability of an mHealth, home-based exercise intervention in colorectal cancer survivors: A pilot randomized controlled trial |
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