Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation
Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (...
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| Veröffentlicht in: | PloS one 2023-06, Vol.18 (6), p.e0285782 |
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| description | Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism. |
| doi_str_mv | 10.1371/journal.pone.0285782 |
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We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0285782</identifier><identifier>PMID: 37294822</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>alpha-Linolenic Acid ; Analysis ; Animals ; B cells ; Bears ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; Biology and Life Sciences ; Body fat ; Body temperature ; Cell membranes ; Consciousness ; Diet ; Docosahexaenoic acid ; Earth Sciences ; Eicosapentaenoic acid ; Eicosapentaenoic Acid - metabolism ; Eliomys quercinus ; Environmental aspects ; Fatty acids ; Fatty Acids - metabolism ; Fatty Acids, Omega-3 ; Fysiologi ; Health aspects ; Heart ; Hibernation ; Hibernation - physiology ; Hypothermia ; Investigations ; Linoleic Acid ; Linolenic acid ; Linolenic acids ; Lipids ; Medicine and Health Sciences ; Metabolism ; Monounsaturated fatty acids ; Myoxidae - metabolism ; Omega-3 fatty acids ; Phenotypes ; Phospholipids ; Phospholipids - metabolism ; Physiological aspects ; Physiology ; Seasonal variations ; Sleep ; Social Sciences ; Ursidae - metabolism ; Ursus arctos ; Zoologi ; Zoology</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0285782</ispartof><rights>Copyright: © 2023 Strandvik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Strandvik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Strandvik et al 2023 Strandvik et al</rights><rights>2023 Strandvik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism.</description><subject>alpha-Linolenic Acid</subject><subject>Analysis</subject><subject>Animals</subject><subject>B cells</subject><subject>Bears</subject><subject>Biochemistry and Molecular Biology</subject><subject>Biokemi och molekylärbiologi</subject><subject>Biology and Life Sciences</subject><subject>Body fat</subject><subject>Body temperature</subject><subject>Cell membranes</subject><subject>Consciousness</subject><subject>Diet</subject><subject>Docosahexaenoic acid</subject><subject>Earth Sciences</subject><subject>Eicosapentaenoic acid</subject><subject>Eicosapentaenoic Acid - metabolism</subject><subject>Eliomys quercinus</subject><subject>Environmental aspects</subject><subject>Fatty acids</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids, 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Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Örebro universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Örebro universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strandvik, Birgitta</au><au>Qureshi, Abdul Rashid</au><au>Painer, Johanna</au><au>Backman-Johansson, Carolina</au><au>Engvall, Martin</au><au>Fröbert, Ole</au><au>Kindberg, Jonas</au><au>Stenvinkel, Peter</au><au>Giroud, Sylvain</au><au>Sakakibara, Manabu</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-09</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0285782</spage><pages>e0285782-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37294822</pmid><doi>10.1371/journal.pone.0285782</doi><tpages>e0285782</tpages><orcidid>https://orcid.org/0000-0001-5323-8272</orcidid><orcidid>https://orcid.org/0000-0001-6621-7462</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-06, Vol.18 (6), p.e0285782 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2824314075 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | alpha-Linolenic Acid Analysis Animals B cells Bears Biochemistry and Molecular Biology Biokemi och molekylärbiologi Biology and Life Sciences Body fat Body temperature Cell membranes Consciousness Diet Docosahexaenoic acid Earth Sciences Eicosapentaenoic acid Eicosapentaenoic Acid - metabolism Eliomys quercinus Environmental aspects Fatty acids Fatty Acids - metabolism Fatty Acids, Omega-3 Fysiologi Health aspects Heart Hibernation Hibernation - physiology Hypothermia Investigations Linoleic Acid Linolenic acid Linolenic acids Lipids Medicine and Health Sciences Metabolism Monounsaturated fatty acids Myoxidae - metabolism Omega-3 fatty acids Phenotypes Phospholipids Phospholipids - metabolism Physiological aspects Physiology Seasonal variations Sleep Social Sciences Ursidae - metabolism Ursus arctos Zoologi Zoology |
| title | Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T19%3A08%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevated%20plasma%20phospholipid%20n-3%20docosapentaenoic%20acid%20concentrations%20during%20hibernation&rft.jtitle=PloS%20one&rft.au=Strandvik,%20Birgitta&rft.aucorp=Sveriges%20lantbruksuniversitet&rft.date=2023-06-09&rft.volume=18&rft.issue=6&rft.spage=e0285782&rft.pages=e0285782-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0285782&rft_dat=%3Cgale_plos_%3EA752406020%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2824314075&rft_id=info:pmid/37294822&rft_galeid=A752406020&rft_doaj_id=oai_doaj_org_article_80fc79b1b8e14833ab9b0848ab8c3743&rfr_iscdi=true |