Protein production from HEK293 cell line-derived stable pools with high protein quality and quantity to support discovery research

Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications. Among the available mammalian cell lines used for recombinant protein expression, Chinese hamster ovary (CHO)-derived suspension...

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Veröffentlicht in:	PloS one 2023-06, Vol.18 (6), p.e0285971-e0285971
Hauptverfasser:	Sun, Hong, Wang, Songyu, Lu, Mei, Tinberg, Christine E, Alba, Benjamin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibiotics Antibodies Biology Biology and Life Sciences Cell culture Cell lines CHO Cells Cloning Cricetinae Cricetulus Crystallography Efficiency Gene amplification Genetic engineering Genomes Glycosylation Health aspects HEK293 Cells Humans Kidney - metabolism Mammals N-Acetylglucosinyldiphosphodolichol N-acetylglucosaminyltransferase Pharmaceutical industry Polysaccharides Pools Post-translation Protein expression Proteins Reagents Recombinant Proteins - chemistry Research and Analysis Methods Research projects Translation Viral antibodies X-ray crystallography
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