The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impac...
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| Veröffentlicht in: | PloS one 2023-06, Vol.18 (6), p.e0286386 |
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| creator | Tsianou, Chrysostomi Christina Kvetina, Jaroslav Radochova, Vera Kohoutova, Darina Rejchrt, Stanislav Valis, Martin Zdarova Karasova, Jana Tacheci, Ilja Knoblochova, Veronika Soukup, Ondrej Bures, Jan |
| description | Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impact of rivastigmine on gastric motor function by means of electrogastrography (EGG) in experimental pigs.
Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes).
In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5-2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577-1375; p = 0.001) and T10 (992.5; 385-2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549-5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434-1476; p = 0.002) and T8 (799; 435-1463 μV2; p = 0.004).
Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans. |
| doi_str_mv | 10.1371/journal.pone.0286386 |
| format | Article |
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Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes).
In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5-2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577-1375; p = 0.001) and T10 (992.5; 385-2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549-5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434-1476; p = 0.002) and T8 (799; 435-1463 μV2; p = 0.004).
Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0286386</identifier><identifier>PMID: 37262057</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Alzheimer Disease ; Alzheimer's disease ; Alzheimers disease ; Amplitudes ; Analysis ; Animals ; Biology and Life Sciences ; Cholinesterase ; Cholinesterase inhibitors ; Cholinesterase Inhibitors - pharmacology ; Dementia ; Dementia disorders ; Diet ; Dosage and administration ; Drug therapy ; Dyspepsia ; Eggs ; Electromyography ; Fasting ; Female ; Gastrointestinal Tract ; General anesthesia ; Health aspects ; Humans ; Hybrids ; Hydrogen ; Infant ; Intervals ; Medicine and Health Sciences ; Myoelectricity ; Neurodegenerative diseases ; Normal distribution ; Patient outcomes ; Phenylcarbamates - pharmacology ; Physical Sciences ; Recording ; Research and Analysis Methods ; Rivastigmine ; Rivastigmine - pharmacology ; Side effects ; Standard deviation ; Stomach ; Sus scrofa domesticus ; Swine</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0286386</ispartof><rights>Copyright: © 2023 Tsianou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Tsianou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Tsianou et al 2023 Tsianou et al</rights><rights>2023 Tsianou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-d34427344d2f79c7441fd1953d71646914a7c1619ff9303478a05bf6b0e28cbf3</cites><orcidid>0000-0003-0326-117X ; 0000-0002-1477-5451 ; 0000-0001-5166-9503 ; 0000-0003-0891-9591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234519/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234519/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37262057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsianou, Chrysostomi Christina</creatorcontrib><creatorcontrib>Kvetina, Jaroslav</creatorcontrib><creatorcontrib>Radochova, Vera</creatorcontrib><creatorcontrib>Kohoutova, Darina</creatorcontrib><creatorcontrib>Rejchrt, Stanislav</creatorcontrib><creatorcontrib>Valis, Martin</creatorcontrib><creatorcontrib>Zdarova Karasova, Jana</creatorcontrib><creatorcontrib>Tacheci, Ilja</creatorcontrib><creatorcontrib>Knoblochova, Veronika</creatorcontrib><creatorcontrib>Soukup, Ondrej</creatorcontrib><creatorcontrib>Bures, Jan</creatorcontrib><title>The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impact of rivastigmine on gastric motor function by means of electrogastrography (EGG) in experimental pigs.
Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes).
In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5-2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577-1375; p = 0.001) and T10 (992.5; 385-2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549-5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434-1476; p = 0.002) and T8 (799; 435-1463 μV2; p = 0.004).
Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans.</description><subject>Abdomen</subject><subject>Alzheimer Disease</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Amplitudes</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Cholinesterase</subject><subject>Cholinesterase inhibitors</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Diet</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Dyspepsia</subject><subject>Eggs</subject><subject>Electromyography</subject><subject>Fasting</subject><subject>Female</subject><subject>Gastrointestinal Tract</subject><subject>General anesthesia</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hybrids</subject><subject>Hydrogen</subject><subject>Infant</subject><subject>Intervals</subject><subject>Medicine and Health Sciences</subject><subject>Myoelectricity</subject><subject>Neurodegenerative diseases</subject><subject>Normal distribution</subject><subject>Patient outcomes</subject><subject>Phenylcarbamates - pharmacology</subject><subject>Physical Sciences</subject><subject>Recording</subject><subject>Research and Analysis Methods</subject><subject>Rivastigmine</subject><subject>Rivastigmine - pharmacology</subject><subject>Side effects</subject><subject>Standard deviation</subject><subject>Stomach</subject><subject>Sus scrofa domesticus</subject><subject>Swine</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk22L1DAQx4so3rn6DUQLguiLXZuHJu0rOQ4fFg4O9PRtSNNJN0varE263H5709vesZV7IYEmnfzmn5lJJkleo2yFCEeftm7oO2lXO9fBKsMFIwV7kpyjkuAlwxl5erI-S154v82yPDLseXJGOI7mnJ8n9mYDKWgNKqROp950jYVUdnXaww5kgDqtnQc_bvZmL30wTWs6SF2XNvGvNyptDw5sFBjXUgWzN-GQmi6F2x30poUuSJvuTONfJs-0tB5eTfMi-fX1y83l9-XV9bf15cXVUjGKw7ImlGIePzXWvFScUqRrVOak5ohRViIquUIMlVqXJCOUFzLLK82qDHChKk0Wyduj7s46L6ZCeYELjBjJKOKRWB-J2smt2MUoZX8QThpxZ3B9I2QfjLIgUIFyonBWswrTSqoSIcVKWnEqFc6pjFqfp9OGqoVaxXx7aWei853ObETj9gJlmNA8XtIi-TAp9O7PAD6I1ngF1soO3HAXOCacIDYG_u4f9PH0JqqRMQPTaRcPVqOouOA5oggVOYvU6hEqjhpao-Kz0ibaZw4fZw6RCXAbGjl4L9Y_f_w_e_17zr4_YTcgbdh4Z4dgXOfnID2Cqnfe96AfqowyMXbFfTXE2BVi6oro9ub0hh6c7tuA_AUySwbG</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Tsianou, Chrysostomi Christina</creator><creator>Kvetina, Jaroslav</creator><creator>Radochova, Vera</creator><creator>Kohoutova, Darina</creator><creator>Rejchrt, Stanislav</creator><creator>Valis, Martin</creator><creator>Zdarova Karasova, Jana</creator><creator>Tacheci, Ilja</creator><creator>Knoblochova, Veronika</creator><creator>Soukup, Ondrej</creator><creator>Bures, Jan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0326-117X</orcidid><orcidid>https://orcid.org/0000-0002-1477-5451</orcidid><orcidid>https://orcid.org/0000-0001-5166-9503</orcidid><orcidid>https://orcid.org/0000-0003-0891-9591</orcidid></search><sort><creationdate>20230601</creationdate><title>The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs</title><author>Tsianou, Chrysostomi Christina ; Kvetina, Jaroslav ; Radochova, Vera ; Kohoutova, Darina ; Rejchrt, Stanislav ; Valis, Martin ; Zdarova Karasova, Jana ; Tacheci, Ilja ; Knoblochova, Veronika ; Soukup, Ondrej ; Bures, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-d34427344d2f79c7441fd1953d71646914a7c1619ff9303478a05bf6b0e28cbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdomen</topic><topic>Alzheimer Disease</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Amplitudes</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Cholinesterase</topic><topic>Cholinesterase inhibitors</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Diet</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Dyspepsia</topic><topic>Eggs</topic><topic>Electromyography</topic><topic>Fasting</topic><topic>Female</topic><topic>Gastrointestinal Tract</topic><topic>General anesthesia</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hybrids</topic><topic>Hydrogen</topic><topic>Infant</topic><topic>Intervals</topic><topic>Medicine and Health Sciences</topic><topic>Myoelectricity</topic><topic>Neurodegenerative diseases</topic><topic>Normal distribution</topic><topic>Patient outcomes</topic><topic>Phenylcarbamates - pharmacology</topic><topic>Physical Sciences</topic><topic>Recording</topic><topic>Research and Analysis Methods</topic><topic>Rivastigmine</topic><topic>Rivastigmine - pharmacology</topic><topic>Side effects</topic><topic>Standard deviation</topic><topic>Stomach</topic><topic>Sus scrofa domesticus</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsianou, Chrysostomi Christina</creatorcontrib><creatorcontrib>Kvetina, Jaroslav</creatorcontrib><creatorcontrib>Radochova, Vera</creatorcontrib><creatorcontrib>Kohoutova, Darina</creatorcontrib><creatorcontrib>Rejchrt, Stanislav</creatorcontrib><creatorcontrib>Valis, Martin</creatorcontrib><creatorcontrib>Zdarova Karasova, Jana</creatorcontrib><creatorcontrib>Tacheci, Ilja</creatorcontrib><creatorcontrib>Knoblochova, Veronika</creatorcontrib><creatorcontrib>Soukup, Ondrej</creatorcontrib><creatorcontrib>Bures, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsianou, Chrysostomi Christina</au><au>Kvetina, Jaroslav</au><au>Radochova, Vera</au><au>Kohoutova, Darina</au><au>Rejchrt, Stanislav</au><au>Valis, Martin</au><au>Zdarova Karasova, Jana</au><au>Tacheci, Ilja</au><au>Knoblochova, Veronika</au><au>Soukup, Ondrej</au><au>Bures, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0286386</spage><pages>e0286386-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impact of rivastigmine on gastric motor function by means of electrogastrography (EGG) in experimental pigs.
Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes).
In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5-2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577-1375; p = 0.001) and T10 (992.5; 385-2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549-5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434-1476; p = 0.002) and T8 (799; 435-1463 μV2; p = 0.004).
Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37262057</pmid><doi>10.1371/journal.pone.0286386</doi><tpages>e0286386</tpages><orcidid>https://orcid.org/0000-0003-0326-117X</orcidid><orcidid>https://orcid.org/0000-0002-1477-5451</orcidid><orcidid>https://orcid.org/0000-0001-5166-9503</orcidid><orcidid>https://orcid.org/0000-0003-0891-9591</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-06, Vol.18 (6), p.e0286386 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2821630417 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abdomen Alzheimer Disease Alzheimer's disease Alzheimers disease Amplitudes Analysis Animals Biology and Life Sciences Cholinesterase Cholinesterase inhibitors Cholinesterase Inhibitors - pharmacology Dementia Dementia disorders Diet Dosage and administration Drug therapy Dyspepsia Eggs Electromyography Fasting Female Gastrointestinal Tract General anesthesia Health aspects Humans Hybrids Hydrogen Infant Intervals Medicine and Health Sciences Myoelectricity Neurodegenerative diseases Normal distribution Patient outcomes Phenylcarbamates - pharmacology Physical Sciences Recording Research and Analysis Methods Rivastigmine Rivastigmine - pharmacology Side effects Standard deviation Stomach Sus scrofa domesticus Swine |
| title | The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs |
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