Humoral immunogenicity of a Coronavirus Disease 2019 (COVID-19) DNA vaccine in rhesus macaques (Macaca mulatta) delivered using needle-free jet injection

A SARS-CoV-2 DNA vaccine targeting the spike protein and delivered by jet injection, nCOV-S(JET), previously shown to protect wild-type and immunosuppressed Syrian hamsters (Mesocricetus auratus), was evaluated via two needle-free delivery methods in rhesus macaques (Macaca mulatta). The methods inc...

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Veröffentlicht in:	PloS one 2023-05, Vol.18 (5), p.e0275082-e0275082
Hauptverfasser:	Jay, Alexandra, Kwilas, Steven A, Josleyn, Matthew, Ricks, Keersten, Hooper, Jay W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Antibodies, Neutralizing Antibodies, Viral Biology and Life Sciences Broadly Neutralizing Antibodies Clinical trials Cloning Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 Vaccines Deoxyribonucleic acid DNA DNA vaccines Free jets Hamsters Immunogenicity Immunogenicity, Vaccine Injection Injections, Jet Laboratory animals Macaca mulatta Medicine and Health Sciences Neutralizing Pandemics Plasmids Research and Analysis Methods SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein Vaccination - methods Vaccines Vaccines, DNA Viral diseases
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