A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis
Periodontitis is a chronic multifactorial inflammatory disease linked to oral microbiota dysbiosis. This disease progresses to infection that stimulates a host immune/inflammatory response, with progressive destruction of the tooth-supporting structures. This systematic review aims to present a robu...
Gespeichert in:
| Veröffentlicht in: | PloS one 2023-05, Vol.18 (5), p.e0286079-e0286079 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0286079 |
|---|---|
| container_issue | 5 |
| container_start_page | e0286079 |
| container_title | PloS one |
| container_volume | 18 |
| creator | Sánchez-Medrano, Ana G Martinez-Martinez, Rita E Soria-Guerra, Ruth Portales-Perez, Diana Bach, Horacio Martinez-Gutierrez, Fidel |
| description | Periodontitis is a chronic multifactorial inflammatory disease linked to oral microbiota dysbiosis. This disease progresses to infection that stimulates a host immune/inflammatory response, with progressive destruction of the tooth-supporting structures.
This systematic review aims to present a robust critical evaluation of the evidence of salivary protein profiles for identifying oral diseases using proteomic approaches and summarize the use of these approaches to diagnose chronic periodontitis.
A systematic literature search was conducted from January 1st, 2010, to December 1st, 2022, based on PICO criteria following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and by searching the three databases Science Direct, Scopus, and Springer Link.
According to the inclusion criteria, eight studies were identified to analyze the proteins identified by proteomics.
The protein family S100 was identified as the most abundant in patients with chronic periodontitis. In this family, an increased abundance of S100A8 and S100A9 from individuals with the active disease was observed, which strongly relates to the inflammatory response. Moreover, the ratio S100A8/S100A9 and the metalloproteinase-8 in saliva could differentiate distinct periodontitis groups. The changes in protein profile after non-surgical periodontal therapy improved the health of the buccal area. The results of this systematic review identified a set of proteins that could be used as a complementary tool for periodontitis diagnosis using salivary proteins.
Biomarkers in saliva can be used to monitor an early stage of periodontitis and the progression of the disease following therapy. |
| doi_str_mv | 10.1371/journal.pone.0286079 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2818717342</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A750485877</galeid><doaj_id>oai_doaj_org_article_81fbcd4d6f76463a9c0c26296bcd94de</doaj_id><sourcerecordid>A750485877</sourcerecordid><originalsourceid>FETCH-LOGICAL-c693t-61c5abdf335abf020c80823b597502b208054453f388be2160d527b5c17f48993</originalsourceid><addsrcrecordid>eNqNk82O0zAQxyMEYpeFN0AQCQnBocVfsZ0TqlYLVFppJb6uluM4jaskDrbT0jfYx8Zts0uD9oBycDTzm_94xjNJ8hKCOcQMfljbwXWymfe203OAOAUsf5ScwxyjGUUAPz75P0ueeb8GIMOc0qfJGWYIEUjBeXK7SP3OB93KYFTq9MbobWqrNNQ67Z0N2nSpsm1vvQnGdnvXtraNTr1szEam0e2HYq1V8OnWhDqttWxCvUt77YwtbRfM0B4UpNPlEVG1s13M9hcJxj9PnlSy8frFeF4kPz5dfb_8Mru--by8XFzPFM1xmFGoMlmUFcbxqAACigOOcJHlLAOoQICDjJAMV5jzQqNYY5khVmQKsorwPMcXyeujbt9YL8YmeoE45AwyTFAklkeitHItemda6XbCSiMOButWQrrYrUYLDqtClaSkFaOEYpkroBBFOY3WnJQ6an0csw1Fq0ulu-BkMxGdejpTi5XdCBhL44TyqPBuVHD216B9EK3xSjeN7LQdDhfPEeMEwIi--Qd9uLyRWslYgekqGxOrvahYxB4SnnHGIjV_gIpfqVuj4shVJtonAe8nAZEJ-ndYycF7sfz29f_Zm59T9u0Je5wub5thP41-CpIjqJz13unqvssQiP3G3HVD7DdGjBsTw16dvtB90N2K4D83ZBL5</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2818717342</pqid></control><display><type>article</type><title>A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Sánchez-Medrano, Ana G ; Martinez-Martinez, Rita E ; Soria-Guerra, Ruth ; Portales-Perez, Diana ; Bach, Horacio ; Martinez-Gutierrez, Fidel</creator><creatorcontrib>Sánchez-Medrano, Ana G ; Martinez-Martinez, Rita E ; Soria-Guerra, Ruth ; Portales-Perez, Diana ; Bach, Horacio ; Martinez-Gutierrez, Fidel</creatorcontrib><description>Periodontitis is a chronic multifactorial inflammatory disease linked to oral microbiota dysbiosis. This disease progresses to infection that stimulates a host immune/inflammatory response, with progressive destruction of the tooth-supporting structures.
This systematic review aims to present a robust critical evaluation of the evidence of salivary protein profiles for identifying oral diseases using proteomic approaches and summarize the use of these approaches to diagnose chronic periodontitis.
A systematic literature search was conducted from January 1st, 2010, to December 1st, 2022, based on PICO criteria following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and by searching the three databases Science Direct, Scopus, and Springer Link.
According to the inclusion criteria, eight studies were identified to analyze the proteins identified by proteomics.
The protein family S100 was identified as the most abundant in patients with chronic periodontitis. In this family, an increased abundance of S100A8 and S100A9 from individuals with the active disease was observed, which strongly relates to the inflammatory response. Moreover, the ratio S100A8/S100A9 and the metalloproteinase-8 in saliva could differentiate distinct periodontitis groups. The changes in protein profile after non-surgical periodontal therapy improved the health of the buccal area. The results of this systematic review identified a set of proteins that could be used as a complementary tool for periodontitis diagnosis using salivary proteins.
Biomarkers in saliva can be used to monitor an early stage of periodontitis and the progression of the disease following therapy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0286079</identifier><identifier>PMID: 37224160</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alzheimer's disease ; Alzheimers disease ; Bias ; Biology and Life Sciences ; Biomarkers ; Calgranulin A ; Calgranulin B ; Chronic Periodontitis - diagnosis ; Chronic Periodontitis - therapy ; Cohort analysis ; Comparative analysis ; Complications and side effects ; Composition ; Criteria ; Development and progression ; Diabetes ; Diagnosis ; Dysbacteriosis ; Exocrine glands ; Gum disease ; Health aspects ; Humans ; Infection ; Inflammatory diseases ; Inflammatory response ; Literature reviews ; Medical Subject Headings-MeSH ; Medicine and Health Sciences ; Metalloproteinase ; Microbiota (Symbiotic organisms) ; Microorganisms ; Neutrophil collagenase ; Periodontal Ligament ; Periodontitis ; Periodontium ; Physical Sciences ; Protein composition ; Proteins ; Proteomics ; Research and Analysis Methods ; Saliva ; Systematic review ; Teeth</subject><ispartof>PloS one, 2023-05, Vol.18 (5), p.e0286079-e0286079</ispartof><rights>Copyright: © 2023 Sánchez-Medrano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Sánchez-Medrano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Sánchez-Medrano et al 2023 Sánchez-Medrano et al</rights><rights>2023 Sánchez-Medrano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-61c5abdf335abf020c80823b597502b208054453f388be2160d527b5c17f48993</citedby><cites>FETCH-LOGICAL-c693t-61c5abdf335abf020c80823b597502b208054453f388be2160d527b5c17f48993</cites><orcidid>0000-0002-7740-9299</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208468/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208468/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37224160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sánchez-Medrano, Ana G</creatorcontrib><creatorcontrib>Martinez-Martinez, Rita E</creatorcontrib><creatorcontrib>Soria-Guerra, Ruth</creatorcontrib><creatorcontrib>Portales-Perez, Diana</creatorcontrib><creatorcontrib>Bach, Horacio</creatorcontrib><creatorcontrib>Martinez-Gutierrez, Fidel</creatorcontrib><title>A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Periodontitis is a chronic multifactorial inflammatory disease linked to oral microbiota dysbiosis. This disease progresses to infection that stimulates a host immune/inflammatory response, with progressive destruction of the tooth-supporting structures.
This systematic review aims to present a robust critical evaluation of the evidence of salivary protein profiles for identifying oral diseases using proteomic approaches and summarize the use of these approaches to diagnose chronic periodontitis.
A systematic literature search was conducted from January 1st, 2010, to December 1st, 2022, based on PICO criteria following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and by searching the three databases Science Direct, Scopus, and Springer Link.
According to the inclusion criteria, eight studies were identified to analyze the proteins identified by proteomics.
The protein family S100 was identified as the most abundant in patients with chronic periodontitis. In this family, an increased abundance of S100A8 and S100A9 from individuals with the active disease was observed, which strongly relates to the inflammatory response. Moreover, the ratio S100A8/S100A9 and the metalloproteinase-8 in saliva could differentiate distinct periodontitis groups. The changes in protein profile after non-surgical periodontal therapy improved the health of the buccal area. The results of this systematic review identified a set of proteins that could be used as a complementary tool for periodontitis diagnosis using salivary proteins.
Biomarkers in saliva can be used to monitor an early stage of periodontitis and the progression of the disease following therapy.</description><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Calgranulin A</subject><subject>Calgranulin B</subject><subject>Chronic Periodontitis - diagnosis</subject><subject>Chronic Periodontitis - therapy</subject><subject>Cohort analysis</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Composition</subject><subject>Criteria</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Dysbacteriosis</subject><subject>Exocrine glands</subject><subject>Gum disease</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infection</subject><subject>Inflammatory diseases</subject><subject>Inflammatory response</subject><subject>Literature reviews</subject><subject>Medical Subject Headings-MeSH</subject><subject>Medicine and Health Sciences</subject><subject>Metalloproteinase</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Neutrophil collagenase</subject><subject>Periodontal Ligament</subject><subject>Periodontitis</subject><subject>Periodontium</subject><subject>Physical Sciences</subject><subject>Protein composition</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Research and Analysis Methods</subject><subject>Saliva</subject><subject>Systematic review</subject><subject>Teeth</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk82O0zAQxyMEYpeFN0AQCQnBocVfsZ0TqlYLVFppJb6uluM4jaskDrbT0jfYx8Zts0uD9oBycDTzm_94xjNJ8hKCOcQMfljbwXWymfe203OAOAUsf5ScwxyjGUUAPz75P0ueeb8GIMOc0qfJGWYIEUjBeXK7SP3OB93KYFTq9MbobWqrNNQ67Z0N2nSpsm1vvQnGdnvXtraNTr1szEam0e2HYq1V8OnWhDqttWxCvUt77YwtbRfM0B4UpNPlEVG1s13M9hcJxj9PnlSy8frFeF4kPz5dfb_8Mru--by8XFzPFM1xmFGoMlmUFcbxqAACigOOcJHlLAOoQICDjJAMV5jzQqNYY5khVmQKsorwPMcXyeujbt9YL8YmeoE45AwyTFAklkeitHItemda6XbCSiMOButWQrrYrUYLDqtClaSkFaOEYpkroBBFOY3WnJQ6an0csw1Fq0ulu-BkMxGdejpTi5XdCBhL44TyqPBuVHD216B9EK3xSjeN7LQdDhfPEeMEwIi--Qd9uLyRWslYgekqGxOrvahYxB4SnnHGIjV_gIpfqVuj4shVJtonAe8nAZEJ-ndYycF7sfz29f_Zm59T9u0Je5wub5thP41-CpIjqJz13unqvssQiP3G3HVD7DdGjBsTw16dvtB90N2K4D83ZBL5</recordid><startdate>20230524</startdate><enddate>20230524</enddate><creator>Sánchez-Medrano, Ana G</creator><creator>Martinez-Martinez, Rita E</creator><creator>Soria-Guerra, Ruth</creator><creator>Portales-Perez, Diana</creator><creator>Bach, Horacio</creator><creator>Martinez-Gutierrez, Fidel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7740-9299</orcidid></search><sort><creationdate>20230524</creationdate><title>A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis</title><author>Sánchez-Medrano, Ana G ; Martinez-Martinez, Rita E ; Soria-Guerra, Ruth ; Portales-Perez, Diana ; Bach, Horacio ; Martinez-Gutierrez, Fidel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-61c5abdf335abf020c80823b597502b208054453f388be2160d527b5c17f48993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>Bias</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Calgranulin A</topic><topic>Calgranulin B</topic><topic>Chronic Periodontitis - diagnosis</topic><topic>Chronic Periodontitis - therapy</topic><topic>Cohort analysis</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Composition</topic><topic>Criteria</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Dysbacteriosis</topic><topic>Exocrine glands</topic><topic>Gum disease</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infection</topic><topic>Inflammatory diseases</topic><topic>Inflammatory response</topic><topic>Literature reviews</topic><topic>Medical Subject Headings-MeSH</topic><topic>Medicine and Health Sciences</topic><topic>Metalloproteinase</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Microorganisms</topic><topic>Neutrophil collagenase</topic><topic>Periodontal Ligament</topic><topic>Periodontitis</topic><topic>Periodontium</topic><topic>Physical Sciences</topic><topic>Protein composition</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Research and Analysis Methods</topic><topic>Saliva</topic><topic>Systematic review</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez-Medrano, Ana G</creatorcontrib><creatorcontrib>Martinez-Martinez, Rita E</creatorcontrib><creatorcontrib>Soria-Guerra, Ruth</creatorcontrib><creatorcontrib>Portales-Perez, Diana</creatorcontrib><creatorcontrib>Bach, Horacio</creatorcontrib><creatorcontrib>Martinez-Gutierrez, Fidel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez-Medrano, Ana G</au><au>Martinez-Martinez, Rita E</au><au>Soria-Guerra, Ruth</au><au>Portales-Perez, Diana</au><au>Bach, Horacio</au><au>Martinez-Gutierrez, Fidel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-05-24</date><risdate>2023</risdate><volume>18</volume><issue>5</issue><spage>e0286079</spage><epage>e0286079</epage><pages>e0286079-e0286079</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Periodontitis is a chronic multifactorial inflammatory disease linked to oral microbiota dysbiosis. This disease progresses to infection that stimulates a host immune/inflammatory response, with progressive destruction of the tooth-supporting structures.
This systematic review aims to present a robust critical evaluation of the evidence of salivary protein profiles for identifying oral diseases using proteomic approaches and summarize the use of these approaches to diagnose chronic periodontitis.
A systematic literature search was conducted from January 1st, 2010, to December 1st, 2022, based on PICO criteria following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and by searching the three databases Science Direct, Scopus, and Springer Link.
According to the inclusion criteria, eight studies were identified to analyze the proteins identified by proteomics.
The protein family S100 was identified as the most abundant in patients with chronic periodontitis. In this family, an increased abundance of S100A8 and S100A9 from individuals with the active disease was observed, which strongly relates to the inflammatory response. Moreover, the ratio S100A8/S100A9 and the metalloproteinase-8 in saliva could differentiate distinct periodontitis groups. The changes in protein profile after non-surgical periodontal therapy improved the health of the buccal area. The results of this systematic review identified a set of proteins that could be used as a complementary tool for periodontitis diagnosis using salivary proteins.
Biomarkers in saliva can be used to monitor an early stage of periodontitis and the progression of the disease following therapy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37224160</pmid><doi>10.1371/journal.pone.0286079</doi><tpages>e0286079</tpages><orcidid>https://orcid.org/0000-0002-7740-9299</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-05, Vol.18 (5), p.e0286079-e0286079 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2818717342 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alzheimer's disease Alzheimers disease Bias Biology and Life Sciences Biomarkers Calgranulin A Calgranulin B Chronic Periodontitis - diagnosis Chronic Periodontitis - therapy Cohort analysis Comparative analysis Complications and side effects Composition Criteria Development and progression Diabetes Diagnosis Dysbacteriosis Exocrine glands Gum disease Health aspects Humans Infection Inflammatory diseases Inflammatory response Literature reviews Medical Subject Headings-MeSH Medicine and Health Sciences Metalloproteinase Microbiota (Symbiotic organisms) Microorganisms Neutrophil collagenase Periodontal Ligament Periodontitis Periodontium Physical Sciences Protein composition Proteins Proteomics Research and Analysis Methods Saliva Systematic review Teeth |
| title | A systematic review of the protein composition of whole saliva in subjects with healthy periodontium compared with chronic periodontitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T02%3A56%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20systematic%20review%20of%20the%20protein%20composition%20of%20whole%20saliva%20in%20subjects%20with%20healthy%20periodontium%20compared%20with%20chronic%20periodontitis&rft.jtitle=PloS%20one&rft.au=S%C3%A1nchez-Medrano,%20Ana%20G&rft.date=2023-05-24&rft.volume=18&rft.issue=5&rft.spage=e0286079&rft.epage=e0286079&rft.pages=e0286079-e0286079&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0286079&rft_dat=%3Cgale_plos_%3EA750485877%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2818717342&rft_id=info:pmid/37224160&rft_galeid=A750485877&rft_doaj_id=oai_doaj_org_article_81fbcd4d6f76463a9c0c26296bcd94de&rfr_iscdi=true |