Extravascular optical coherence tomography of cerebral vessel walls in vivo
Evaluation of extravascular, microscope integrated OCT (iOCT) as an in vivo imaging modality of cerebral blood vessels and as an intraoperative imaging method. Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one inciden...
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| creator | Hartmann, Karl Neyazi, Belal Dumitru, Claudia A Haghikia, Aiden Sandalcioglu, I Erol Stein, Klaus-Peter |
| description | Evaluation of extravascular, microscope integrated OCT (iOCT) as an in vivo imaging modality of cerebral blood vessels and as an intraoperative imaging method.
Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one incidental cerebral vasospasm (n = 1) in (n = 10) patients. Post procedural analysis of OCT volume scans, microscopic images and videos during the time of scan as well as measurements of the diameter of vessel walls and its layers with an accuracy of 7.5 μm.
iOCT was feasible during vascular microsurgical procedures. In all scanned arteries a clear delineation of the physiological three layered vessel wall composition could be achieved. Pathological arteriosclerotic alterations of cerebral artery walls could precisely be demonstrated. Major superficial cortical veins conversely presented a mono layered composition. First in vivo measurements of vascular mean diameters were possible. Cerebral artery walls showed a diameter of 296 μm, tunica externa 78 μm, media 134 μm and interna 84 μm.
For the first time the microstructural composition of cerebral blood vessels could be illustrated in vivo. Due to an outstanding spatial resolution a clear definition of physiological and pathological characteristics was possible. Therefore, microscope integrated optical coherence tomography holds promise for basic research in the field of cerebrovascular arteriosclerotic diseases and for intraoperative guidance during microvascular surgery. |
| doi_str_mv | 10.1371/journal.pone.0276307 |
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Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one incidental cerebral vasospasm (n = 1) in (n = 10) patients. Post procedural analysis of OCT volume scans, microscopic images and videos during the time of scan as well as measurements of the diameter of vessel walls and its layers with an accuracy of 7.5 μm.
iOCT was feasible during vascular microsurgical procedures. In all scanned arteries a clear delineation of the physiological three layered vessel wall composition could be achieved. Pathological arteriosclerotic alterations of cerebral artery walls could precisely be demonstrated. Major superficial cortical veins conversely presented a mono layered composition. First in vivo measurements of vascular mean diameters were possible. Cerebral artery walls showed a diameter of 296 μm, tunica externa 78 μm, media 134 μm and interna 84 μm.
For the first time the microstructural composition of cerebral blood vessels could be illustrated in vivo. Due to an outstanding spatial resolution a clear definition of physiological and pathological characteristics was possible. Therefore, microscope integrated optical coherence tomography holds promise for basic research in the field of cerebrovascular arteriosclerotic diseases and for intraoperative guidance during microvascular surgery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0276307</identifier><identifier>PMID: 37195981</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Arteries ; Biology and Life Sciences ; Blood ; Blood vessels ; Brain ; Carotid arteries ; Cerebral Veins ; Coherence (Optics) ; Composition ; Diameters ; Evaluation ; Histology ; Humans ; Hyperplasia ; Light ; Medical imaging ; Medicine and Health Sciences ; Microscopy ; Microvasculature ; Neurosurgery ; Optical Coherence Tomography ; Optics ; Patients ; Physical Sciences ; Physiology ; Research and Analysis Methods ; Spatial discrimination ; Spatial resolution ; Surgeons ; Tomography ; Tomography, Optical Coherence - methods ; Vascular diseases ; Vasoconstriction ; Veins ; Veins & arteries ; Ventricles</subject><ispartof>PloS one, 2023-05, Vol.18 (5), p.e0276307-e0276307</ispartof><rights>Copyright: © 2023 Hartmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Hartmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Hartmann et al 2023 Hartmann et al</rights><rights>2023 Hartmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-d00fdefe72d541da6903b78b397e94cf0bd940a091046fa4104d0df47d0b8dd13</citedby><cites>FETCH-LOGICAL-c693t-d00fdefe72d541da6903b78b397e94cf0bd940a091046fa4104d0df47d0b8dd13</cites><orcidid>0000-0001-6732-952X ; 0000-0002-3163-0545</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191299/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191299/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37195981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartmann, Karl</creatorcontrib><creatorcontrib>Neyazi, Belal</creatorcontrib><creatorcontrib>Dumitru, Claudia A</creatorcontrib><creatorcontrib>Haghikia, Aiden</creatorcontrib><creatorcontrib>Sandalcioglu, I Erol</creatorcontrib><creatorcontrib>Stein, Klaus-Peter</creatorcontrib><title>Extravascular optical coherence tomography of cerebral vessel walls in vivo</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Evaluation of extravascular, microscope integrated OCT (iOCT) as an in vivo imaging modality of cerebral blood vessels and as an intraoperative imaging method.
Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one incidental cerebral vasospasm (n = 1) in (n = 10) patients. Post procedural analysis of OCT volume scans, microscopic images and videos during the time of scan as well as measurements of the diameter of vessel walls and its layers with an accuracy of 7.5 μm.
iOCT was feasible during vascular microsurgical procedures. In all scanned arteries a clear delineation of the physiological three layered vessel wall composition could be achieved. Pathological arteriosclerotic alterations of cerebral artery walls could precisely be demonstrated. Major superficial cortical veins conversely presented a mono layered composition. First in vivo measurements of vascular mean diameters were possible. Cerebral artery walls showed a diameter of 296 μm, tunica externa 78 μm, media 134 μm and interna 84 μm.
For the first time the microstructural composition of cerebral blood vessels could be illustrated in vivo. Due to an outstanding spatial resolution a clear definition of physiological and pathological characteristics was possible. Therefore, microscope integrated optical coherence tomography holds promise for basic research in the field of cerebrovascular arteriosclerotic diseases and for intraoperative guidance during microvascular surgery.</description><subject>Arteries</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood vessels</subject><subject>Brain</subject><subject>Carotid arteries</subject><subject>Cerebral Veins</subject><subject>Coherence (Optics)</subject><subject>Composition</subject><subject>Diameters</subject><subject>Evaluation</subject><subject>Histology</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Light</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Microscopy</subject><subject>Microvasculature</subject><subject>Neurosurgery</subject><subject>Optical Coherence Tomography</subject><subject>Optics</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Research and Analysis Methods</subject><subject>Spatial discrimination</subject><subject>Spatial resolution</subject><subject>Surgeons</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartmann, Karl</au><au>Neyazi, Belal</au><au>Dumitru, Claudia A</au><au>Haghikia, Aiden</au><au>Sandalcioglu, I Erol</au><au>Stein, Klaus-Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extravascular optical coherence tomography of cerebral vessel walls in vivo</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-05-17</date><risdate>2023</risdate><volume>18</volume><issue>5</issue><spage>e0276307</spage><epage>e0276307</epage><pages>e0276307-e0276307</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Evaluation of extravascular, microscope integrated OCT (iOCT) as an in vivo imaging modality of cerebral blood vessels and as an intraoperative imaging method.
Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one incidental cerebral vasospasm (n = 1) in (n = 10) patients. Post procedural analysis of OCT volume scans, microscopic images and videos during the time of scan as well as measurements of the diameter of vessel walls and its layers with an accuracy of 7.5 μm.
iOCT was feasible during vascular microsurgical procedures. In all scanned arteries a clear delineation of the physiological three layered vessel wall composition could be achieved. Pathological arteriosclerotic alterations of cerebral artery walls could precisely be demonstrated. Major superficial cortical veins conversely presented a mono layered composition. First in vivo measurements of vascular mean diameters were possible. Cerebral artery walls showed a diameter of 296 μm, tunica externa 78 μm, media 134 μm and interna 84 μm.
For the first time the microstructural composition of cerebral blood vessels could be illustrated in vivo. Due to an outstanding spatial resolution a clear definition of physiological and pathological characteristics was possible. Therefore, microscope integrated optical coherence tomography holds promise for basic research in the field of cerebrovascular arteriosclerotic diseases and for intraoperative guidance during microvascular surgery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37195981</pmid><doi>10.1371/journal.pone.0276307</doi><tpages>e0276307</tpages><orcidid>https://orcid.org/0000-0001-6732-952X</orcidid><orcidid>https://orcid.org/0000-0002-3163-0545</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arteries Biology and Life Sciences Blood Blood vessels Brain Carotid arteries Cerebral Veins Coherence (Optics) Composition Diameters Evaluation Histology Humans Hyperplasia Light Medical imaging Medicine and Health Sciences Microscopy Microvasculature Neurosurgery Optical Coherence Tomography Optics Patients Physical Sciences Physiology Research and Analysis Methods Spatial discrimination Spatial resolution Surgeons Tomography Tomography, Optical Coherence - methods Vascular diseases Vasoconstriction Veins Veins & arteries Ventricles |
| title | Extravascular optical coherence tomography of cerebral vessel walls in vivo |
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