Conserved NIMA kinases regulate multiple steps of endocytic trafficking

Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8). We previously showed that Caenorhabditis elegans NEKL-2 (NEK8/9 homolog) and NEKL-3 (NEK6/7 homolog) regulat...

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Veröffentlicht in:	PLoS genetics 2023-04, Vol.19 (4), p.e1010741-e1010741
Hauptverfasser:	Joseph, Braveen B, Naslavsky, Naava, Binti, Shaonil, Conquest, Sylvia, Robison, Lexi, Bai, Ge, Homer, Rafael O, Grant, Barth D, Caplan, Steve, Fay, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Animals Biology and Life Sciences Bone Morphogenetic Protein Receptors - metabolism Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell cycle Cell division Cell lines Cell research Cell surface Cells Cellular control mechanisms Clathrin Clathrin - genetics Clathrin - metabolism DNA damage Endocytosis Endocytosis - genetics Endosomes Endosomes - genetics Endosomes - metabolism Epidermis Gene expression Genetic aspects Golgi apparatus Humans Kinases Localization Lysosomes Mannose Molting Nek1 protein NIMA-Related Kinases - genetics NIMA-Related Kinases - metabolism Physiological aspects Protein kinases Protein Transport - genetics Protein turnover Research and Analysis Methods Roles siRNA Worms
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