Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan

Commensal microbes in animals have a profound impact on tissue homeostasis, stress resistance, and ageing. We previously showed in Drosophila melanogaster that Acetobacter persici is a member of the gut microbiota that promotes ageing and shortens fly lifespan. However, the molecular mechanism by wh...

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Veröffentlicht in:	PLoS genetics 2023-04, Vol.19 (4), p.e1010709-e1010709
Hauptverfasser:	Onuma, Taro, Yamauchi, Toshitaka, Kosakamoto, Hina, Kadoguchi, Hibiki, Kuraishi, Takayuki, Murakami, Takumi, Mori, Hiroshi, Miura, Masayuki, Obata, Fumiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amidase Amidohydrolases Animals Antibiotics Antimicrobial peptides Bacteria Bacteria - genetics Biology and Life Sciences Cell walls Contamination Diet Digestive system Digestive tract Drosophila Drosophila - genetics Drosophila melanogaster - physiology Gastrointestinal tract Gnotobiotic Herbicide resistance Herbicides Homeostasis Host-bacteria relationships Insects Intestinal microflora Laboratories Life span Longevity Longevity - genetics Medicine and Health Sciences Metabolites Microbiological research Microbiota Microbiota (Symbiotic organisms) Midgut Molecular modelling Oral infection Paraquat Pathogens Peptidoglycan Peptidoglycan recognition proteins Peptidoglycans Physical Sciences Physiological aspects Physiology Stem cells Transcriptomics Tumor necrosis factor-TNF
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