SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells

The presence of human cytomegalovirus (HCMV) in glioblastoma (GBM) and improved outcomes of GBM patients receiving therapies targeting the virus have implicated HCMV in GBM progression. However, a unifying mechanism that accounts for the contribution of HCMV to the malignant phenotype of GBM remains...

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Veröffentlicht in:	PLoS pathogens 2023-04, Vol.19 (4), p.e1011316-e1011316
Hauptverfasser:	Wen, Le, Wang, Xian-Zhang, Qiu, Yong, Zhou, Yue-Peng, Zhang, Qing-Yang, Cheng, Shuang, Sun, Jin-Yan, Jiang, Xing-Jun, Rayner, Simon, Britt, William J, Chen, Jian, Hu, Fei, Li, Fang-Cheng, Luo, Min-Hua, Cheng, Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Cancer Care and treatment Cytomegalovirus Cytomegalovirus - physiology Cytomegaloviruses Development and progression Down-Regulation Drug resistance Gene Expression Genetic aspects Glioblastoma Glioma Glioma - genetics Glioma - pathology Glioma cells Gliomas Health aspects Humans IE1 protein Immediate-Early Proteins - metabolism Immunodeficiency Infections Leukemia Medicine and Health Sciences Mice Neurospheres Oncology, Experimental Patients Phenotypes Promyeloid leukemia Proteins Research and Analysis Methods SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Viral infections Viruses Xenografts Xenotransplantation
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