Selenoprotein K enhances STING oligomerization to facilitate antiviral response

Stimulator-of-interferon gene (STING) is a vital element of the innate immune system against DNA viruses. Optimal activation of STING is crucial for maintaining immune homeostasis and eliminating invading viruses, and the oligomerization of STING is an essential prerequisite for STING activation. Ho...

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Veröffentlicht in:	PLoS pathogens 2023-04, Vol.19 (4), p.e1011314-e1011314
Hauptverfasser:	Lv, Lin, Chai, Li, Wang, Jie, Wang, Mengge, Qin, Danhui, Song, Hui, Fu, Yue, Zhao, Chunyuan, Jia, Jihui, Zhao, Wei, Jia, Mutian
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antiviral Agents Antiviral drugs Biological response modifiers Biology and life sciences Bites and stings Deoxyribonucleic acid DNA DNA viruses Endoplasmic reticulum Golgi apparatus Health aspects Herpes simplex Herpes viruses Herpesvirus 1, Human - physiology Homeostasis Humans Immune response Immune system Immunity, Innate Infection Infections Innate immunity Interferon Kinases Medicine and Health Sciences Mice Oligomerization Oligomers Pathogens Phosphorylation Physiological aspects Physiology Prevention Priming Properties Research and Analysis Methods Risk factors Selenium Selenoproteins Statistical significance Stimulators Translocation Virus diseases Virus Replication - genetics Viruses
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