Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

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Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2023-04, Vol.21 (4), p.e3002105-e3002105
Hauptverfasser:	Hamilton, Alex G, Swingle, Kelsey L, Mitchell, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amyloidosis Analysis Biodistribution Biology and Life Sciences Biotechnology Coronaviruses COVID-19 vaccines Cytoplasm Engineering and Technology FDA approval Lipids Liposomes Medicine and Health Sciences MicroRNAs Nanoparticles Nucleic Acids Proteins
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.
ISSN:	1545-7885 1544-9173 1545-7885
DOI:	10.1371/journal.pbio.3002105