T cell-mediated tumor killing patterns in head and neck squamous cell carcinoma identify novel molecular subtypes, with prognosis and therapeutic implications
As an important process in cancer immunotherapy, T cell-mediated tumor killing (TTK) enhances the immune response of patients. However, the role of TTK in Head and Neck Squamous Cell Carcinoma (HNSCC) patients still needs further exploration. Therefore, we comprehensively analyzed the gene expressio...
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| description | As an important process in cancer immunotherapy, T cell-mediated tumor killing (TTK) enhances the immune response of patients. However, the role of TTK in Head and Neck Squamous Cell Carcinoma (HNSCC) patients still needs further exploration. Therefore, we comprehensively analyzed the gene expression information and clinical characteristics of 1063 HNSCC in five cohorts. Univariate regression, differential expression analysis, and gene mutation profiling were combined to identify the important genes regulating the sensitivity of tumor cells to T cell-mediated killing (GSTTK) in HNSCC. A total of 20 GSTTK were identified as important genes of HNSCC. Patients were divided into C1 and C2 subgroups (TTK patterns) and displayed significant prognostic differences. Patients with C2 subtype had dismal prognosis characteristic compared to C1 subtype in all validation cohorts. Patients with C1 subgroup exhibited robust immune profile and C1 subgroup patients were significantly enriched in metabolically relevant functions. Notably, the multi-omics analysis found that C1 subgroup have higher mutation burden and C2 subgroup patients had significantly higher copy number variation. Drug sensitivity analysis found that multiple first-line chemotherapeutic drugs were more sensitive in patients with subgroup C1. In conclusion, the establishment of GSTTK provides guidance and assistance to clinicians in the personalized management and treatment of HNSCC patients. |
| doi_str_mv | 10.1371/journal.pone.0285832 |
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However, the role of TTK in Head and Neck Squamous Cell Carcinoma (HNSCC) patients still needs further exploration. Therefore, we comprehensively analyzed the gene expression information and clinical characteristics of 1063 HNSCC in five cohorts. Univariate regression, differential expression analysis, and gene mutation profiling were combined to identify the important genes regulating the sensitivity of tumor cells to T cell-mediated killing (GSTTK) in HNSCC. A total of 20 GSTTK were identified as important genes of HNSCC. Patients were divided into C1 and C2 subgroups (TTK patterns) and displayed significant prognostic differences. Patients with C2 subtype had dismal prognosis characteristic compared to C1 subtype in all validation cohorts. Patients with C1 subgroup exhibited robust immune profile and C1 subgroup patients were significantly enriched in metabolically relevant functions. Notably, the multi-omics analysis found that C1 subgroup have higher mutation burden and C2 subgroup patients had significantly higher copy number variation. Drug sensitivity analysis found that multiple first-line chemotherapeutic drugs were more sensitive in patients with subgroup C1. In conclusion, the establishment of GSTTK provides guidance and assistance to clinicians in the personalized management and treatment of HNSCC patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0285832</identifier><identifier>PMID: 37192179</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Cancer ; Cancer immunotherapy ; Cancer therapies ; Care and treatment ; Chemotherapy ; Clinical medicine ; Copy number ; DNA Copy Number Variations ; FDA approval ; Gene expression ; Genes ; Head & neck cancer ; Head and neck cancer ; Head and neck carcinoma ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - therapy ; Health aspects ; Humans ; Immune response ; Immune system ; Immunosuppressive agents ; Immunotherapy ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Metastasis ; Mutation ; Patient outcomes ; Patients ; Point mutation ; Prognosis ; Sensitivity analysis ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - genetics ; Squamous Cell Carcinoma of Head and Neck - therapy ; Subgroups ; T cells ; T-Lymphocytes ; Tumor cells ; Tumors</subject><ispartof>PloS one, 2023-05, Vol.18 (5), p.e0285832-e0285832</ispartof><rights>Copyright: © 2023 Meng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Meng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Meng et al 2023 Meng et al</rights><rights>2023 Meng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-cbf621598c4320aa3d59118b3c83ed7d3bdfb20ead59f6db5f9f5c13b96636c73</citedby><cites>FETCH-LOGICAL-c693t-cbf621598c4320aa3d59118b3c83ed7d3bdfb20ead59f6db5f9f5c13b96636c73</cites><orcidid>0000-0002-0054-8928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187926/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187926/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37192179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Selvaraj, Gurudeeban</contributor><creatorcontrib>Meng, Zilu</creatorcontrib><creatorcontrib>Zhu, Lei</creatorcontrib><creatorcontrib>Liu, Wanyu</creatorcontrib><creatorcontrib>Yang, Wenhan</creatorcontrib><creatorcontrib>Wang, Yudong</creatorcontrib><title>T cell-mediated tumor killing patterns in head and neck squamous cell carcinoma identify novel molecular subtypes, with prognosis and therapeutic implications</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>As an important process in cancer immunotherapy, T cell-mediated tumor killing (TTK) enhances the immune response of patients. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Zilu</au><au>Zhu, Lei</au><au>Liu, Wanyu</au><au>Yang, Wenhan</au><au>Wang, Yudong</au><au>Selvaraj, Gurudeeban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T cell-mediated tumor killing patterns in head and neck squamous cell carcinoma identify novel molecular subtypes, with prognosis and therapeutic implications</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-05-16</date><risdate>2023</risdate><volume>18</volume><issue>5</issue><spage>e0285832</spage><epage>e0285832</epage><pages>e0285832-e0285832</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>As an important process in cancer immunotherapy, T cell-mediated tumor killing (TTK) enhances the immune response of patients. However, the role of TTK in Head and Neck Squamous Cell Carcinoma (HNSCC) patients still needs further exploration. Therefore, we comprehensively analyzed the gene expression information and clinical characteristics of 1063 HNSCC in five cohorts. Univariate regression, differential expression analysis, and gene mutation profiling were combined to identify the important genes regulating the sensitivity of tumor cells to T cell-mediated killing (GSTTK) in HNSCC. A total of 20 GSTTK were identified as important genes of HNSCC. Patients were divided into C1 and C2 subgroups (TTK patterns) and displayed significant prognostic differences. Patients with C2 subtype had dismal prognosis characteristic compared to C1 subtype in all validation cohorts. Patients with C1 subgroup exhibited robust immune profile and C1 subgroup patients were significantly enriched in metabolically relevant functions. Notably, the multi-omics analysis found that C1 subgroup have higher mutation burden and C2 subgroup patients had significantly higher copy number variation. Drug sensitivity analysis found that multiple first-line chemotherapeutic drugs were more sensitive in patients with subgroup C1. In conclusion, the establishment of GSTTK provides guidance and assistance to clinicians in the personalized management and treatment of HNSCC patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37192179</pmid><doi>10.1371/journal.pone.0285832</doi><tpages>e0285832</tpages><orcidid>https://orcid.org/0000-0002-0054-8928</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Cancer Cancer immunotherapy Cancer therapies Care and treatment Chemotherapy Clinical medicine Copy number DNA Copy Number Variations FDA approval Gene expression Genes Head & neck cancer Head and neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - therapy Health aspects Humans Immune response Immune system Immunosuppressive agents Immunotherapy Lymphocytes Lymphocytes T Medical prognosis Medical research Medicine and Health Sciences Metastasis Mutation Patient outcomes Patients Point mutation Prognosis Sensitivity analysis Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - therapy Subgroups T cells T-Lymphocytes Tumor cells Tumors |
| title | T cell-mediated tumor killing patterns in head and neck squamous cell carcinoma identify novel molecular subtypes, with prognosis and therapeutic implications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T18%3A25%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=T%20cell-mediated%20tumor%20killing%20patterns%20in%20head%20and%20neck%20squamous%20cell%20carcinoma%20identify%20novel%20molecular%20subtypes,%20with%20prognosis%20and%20therapeutic%20implications&rft.jtitle=PloS%20one&rft.au=Meng,%20Zilu&rft.date=2023-05-16&rft.volume=18&rft.issue=5&rft.spage=e0285832&rft.epage=e0285832&rft.pages=e0285832-e0285832&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0285832&rft_dat=%3Cgale_plos_%3EA749504252%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2814337141&rft_id=info:pmid/37192179&rft_galeid=A749504252&rft_doaj_id=oai_doaj_org_article_406701423336450c82fbe165d657c08c&rfr_iscdi=true |