The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1

The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice. To determine whether Orai1 has a direct, cell-intrinsic role in osteoblast differentiation and function, we bred Orai1 flox/f...

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Veröffentlicht in:	PloS one 2023-05, Vol.18 (5), p.e0264596-e0264596
Hauptverfasser:	Robinson, Lisa J, Soboloff, Jonathan, Tourkova, Irina L, Larrouture, Quitterie C, Onwuka, Kelechi M, Papachristou, Dionysios J, Gross, Scott, Hooper, Robert, Samakai, Elsie, Worley, Paul F, Liu, Peng, Tuckermann, Jan, Witt, Michelle R, Blair, Harry C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Alkaline phosphatase Analysis Animals Antibodies Biology and Life Sciences Bone density Bone growth Bone histomorphometry Bone mass Bone resorption Bone turnover Bones Calcium Calcium - metabolism Calcium channels Calcium Channels - genetics Calcium Channels - metabolism Calcium influx Calcium ions Cbfa-1 protein Cell culture Cell differentiation Computed tomography Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Defects Density Ethylenediaminetetraacetic acid Flox Health aspects Homeostasis In vivo methods and tests Ion channels Ions Labeling Medicine and Health Sciences Mice Mice, Knockout Mineralization Orai1 protein ORAI1 Protein - genetics ORAI1 Protein - metabolism Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Osteogenesis Osteoprogenitor cells Penicillin Phosphatase Phosphatases Proteins Stem cells Substrates Tomography Vertebra Vertebrae Viral antibodies
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