Inhibition of ERK signaling for treatment of ERRα positive TNBC

Breast cancer is the second leading cause of cancer-related deaths in women and triple-negative breast cancer (TNBC), in particular, is an aggressive and highly metastatic type of breast cancer that does not respond to established targeted therapies and is associated with poor prognosis and worse su...

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Veröffentlicht in:	PloS one 2023-05, Vol.18 (5), p.e0283047
Hauptverfasser:	Musheyev, David, Miller, Esther, Birnbaum, Natania, Miller, Elisheva, Erblich, Shoshana, Schuck, Alyssa, Alayev, Anya
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Antibodies Apoptosis Biology and life sciences Breast cancer Cancer therapies Cell Line, Tumor Cell Proliferation Chemotherapy Drug Inverse Agonism ERRalpha Estrogen-Related Receptor Estrogens Female Humans Inverse agonists Kinases MAP kinase Medical prognosis Medicine and Health Sciences Metabolism Metastases Metastasis Mortality Phosphatase Phosphorylation Prognosis Proteins Receptors, Estrogen - metabolism Research and Analysis Methods Signaling Subgroups Tamoxifen Tamoxifen - pharmacology Tamoxifen - therapeutic use Target recognition Triple Negative Breast Neoplasms - pathology Tumors Womens health
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