Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

Congenital Zika virus (ZIKV) infection can result in birth defects, including malformations in the fetal brain and visual system. There are two distinct genetic lineages of ZIKV: African and Asian. Asian-lineage ZIKVs have been associated with adverse pregnancy outcomes in humans; however, recent ev...

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Veröffentlicht in:	PloS one 2023-05, Vol.18 (5), p.e0284964
Hauptverfasser:	Koenig, Michelle R, Mitzey, Ann M, Morgan, Terry K, Zeng, Xiankun, Simmons, Heather A, Mejia, Andres, Leyva Jaimes, Fernanda, Keding, Logan T, Crooks, Chelsea M, Weiler, Andrea M, Bohm, Ellie K, Aliota, Matthew T, Friedrich, Thomas C, Mohr, Emma L, Golos, Thaddeus G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic fluid Amniotic Fluid - metabolism Analysis Animals Antibodies Antibodies, Neutralizing Biology and life sciences Birth defects Congenital defects Dams Decidua Diet Disease Models, Animal Disease transmission Epidemics Female Fetuses Humans Hybridization Infections Infectious Disease Transmission, Vertical - veterinary Inoculation Laboratory animals Macaca mulatta Macaca mulatta - genetics Medicine and Health Sciences Membranes Neutralizing Placenta Pregnancy Pregnancy Complications, Infectious - veterinary Research and Analysis Methods Ribonucleic acid RNA Stainless steel Tissues Vector-borne diseases Viremia Viruses Visual system Zika virus Zika Virus - genetics Zika Virus Infection
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