Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip

Adipose-derived stem cells are expected to be applied to regenerative medicine for various incurable diseases including liver cirrhosis. Although microRNAs contained in extracellular vesicles (EV-miRNAs) have been implicated in their regenerative effects, the precise mechanism has not been fully elu...

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Veröffentlicht in:	PloS one 2023-05, Vol.18 (5), p.e0284989-e0284989
Hauptverfasser:	Niitsu, Yoshihiro, Komiya, Chikara, Takeuchi, Akira, Hara, Kazunari, Horino, Masato, Aoki, Jun, Okazaki, Rei, Murakami, Masanori, Tsujimoto, Kazutaka, Ikeda, Kenji, Yamada, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Adipose Tissue - metabolism Adipose tissues Analysis Animal tissues Animals Biology and Life Sciences Body fat Carrier Proteins - metabolism Cell Proliferation Chromosome 3 Circulating MicroRNA - metabolism Cirrhosis Enzymes Ethylenediaminetetraacetic acid Extracellular Vesicles - metabolism Gene expression Health aspects Hepatocytes - metabolism In vivo methods and tests Insulin Laboratories Liver Liver cells Liver cirrhosis Liver Cirrhosis - pathology Liver diseases Medicine Medicine and Health Sciences Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Progenitor cells Reagents Regeneration (physiology) Regenerative medicine Research and Analysis Methods Scientific equipment and supplies industry Stem cells Tamoxifen Thioredoxins - metabolism Tissue engineering
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