Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning

Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C. elegans and use its impact on pharyngeal pumping as a bio-assay to model poisoning through these neuro...

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Veröffentlicht in:	PloS one 2023-04, Vol.18 (4), p.e0284786-e0284786
Hauptverfasser:	Izquierdo, Patricia G, Charvet, Claude L, Neveu, Cedric, Green, A Christopher, Tattersall, John E H, Holden-Dye, Lindy, O'Connor, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Acetylcholinesterase Acetylcholinesterase - metabolism Analysis Animals Biology and Life Sciences Body wall Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Cholinergics Cholinesterase Inhibitors - therapeutic use Diagnosis Drug dosages Experiments Genotype & phenotype Health aspects Intoxication Life Sciences Medicine and Health Sciences Modulation Muscle contraction Nematodes Neurotoxicity Neurotoxins Nicotine Organophosphate Poisoning - drug therapy Organophosphates Organophosphates - therapeutic use Organophosphates - toxicity Paraoxon Paraoxon - therapeutic use Paraoxon - toxicity Pharynx Physical Sciences Poisoning Pumping Receptors Receptors, Nicotinic - genetics Research and Analysis Methods Statistical significance Toxins Worms
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