The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation

DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse line in which a functional fusion protein between DND1 and GFP is expressed from the end...

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Veröffentlicht in:	PLoS genetics 2023-03, Vol.19 (3), p.e1010656
Hauptverfasser:	Ruthig, Victor A, Hatkevich, Talia, Hardy, Josiah, Friedersdorf, Matthew B, Mayère, Chloé, Nef, Serge, Keene, Jack D, Capel, Blanche
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Analysis Animals Apoptosis Binding proteins Biology and Life Sciences Cell cycle Cell differentiation Chromatin Chromatin - metabolism CRISPR DNA methylation Epigenetic inheritance Epigenetics Female Fusion protein Gene expression Genetic aspects Germ cells Gestation Golgi apparatus Histones Identification and classification Immunoprecipitation Inbreeding Male Medicine and Health Sciences Methods Methyltransferases Mice Neoplasm Proteins - genetics Pregnancy Properties Protein binding Proteins Research and analysis methods RNA RNA sequencing RNA-binding protein RNA-Binding Proteins - genetics Spermatogonia Spermatogonia - metabolism Testes Translation Zebrafish - genetics Zebrafish - metabolism
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