Same, same but different: Exploring Plasmodium cell division during liver stage development
Plasmodium parasites have a complex life cycle alternating between a mosquito and a vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication within the host. Successfully invaded sporozoit...
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| creator | Roques, Magali Bindschedler, Annina Beyeler, Raphael Heussler, Volker T |
| description | Plasmodium parasites have a complex life cycle alternating between a mosquito and a vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication within the host. Successfully invaded sporozoites undergo a massive replication and growth involving asynchronous DNA replication and division that results in the generation of tens of thousands or even hundreds of thousands of merozoites depending on the Plasmodium species. The generation of a high number of daughter parasites requires biogenesis and segregation of organelles to finally reach a relatively synchronous cytokinesis event. At the end of liver stage (LS) development, merozoites are packed into merosomes and released into the bloodstream. They are then liberated and infect red blood cells to again produce merozoites by schizogony for the erythrocytic stage of the life cycle. Although parasite LS and asexual blood stage (ABS) differ in many respects, important similarities exist between the two. This review focuses on the cell division of Plasmodium parasite LS in comparison with other life cycle stages especially the parasite blood stage. |
| doi_str_mv | 10.1371/journal.ppat.1011210 |
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Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication within the host. Successfully invaded sporozoites undergo a massive replication and growth involving asynchronous DNA replication and division that results in the generation of tens of thousands or even hundreds of thousands of merozoites depending on the Plasmodium species. The generation of a high number of daughter parasites requires biogenesis and segregation of organelles to finally reach a relatively synchronous cytokinesis event. At the end of liver stage (LS) development, merozoites are packed into merosomes and released into the bloodstream. They are then liberated and infect red blood cells to again produce merozoites by schizogony for the erythrocytic stage of the life cycle. Although parasite LS and asexual blood stage (ABS) differ in many respects, important similarities exist between the two. This review focuses on the cell division of Plasmodium parasite LS in comparison with other life cycle stages especially the parasite blood stage.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1011210</identifier><identifier>PMID: 36996035</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biology and Life Sciences ; Blood ; Blood cells ; Cell cycle ; Cell division ; Cytokinesis ; Deoxyribonucleic acid ; Developmental stages ; DNA ; DNA biosynthesis ; DNA replication ; Erythrocytes ; Exocrine glands ; Gene expression ; Genetic engineering ; Genomes ; Health aspects ; Hepatocytes ; Kinases ; Life Cycle Stages ; Life cycles ; Liver ; Liver - parasitology ; Medicine and Health Sciences ; Merozoites ; Mosquitoes ; Organelles ; Parasites ; Parasitic diseases ; Plasmodium ; Plasmodium - physiology ; Prevention ; Proteins ; Replication ; Review ; Risk factors ; Schizogony ; Skin ; Sporozoites ; Vertebrates</subject><ispartof>PLoS pathogens, 2023-03, Vol.19 (3), p.e1011210-e1011210</ispartof><rights>Copyright: © 2023 Roques et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Roques et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication within the host. Successfully invaded sporozoites undergo a massive replication and growth involving asynchronous DNA replication and division that results in the generation of tens of thousands or even hundreds of thousands of merozoites depending on the Plasmodium species. The generation of a high number of daughter parasites requires biogenesis and segregation of organelles to finally reach a relatively synchronous cytokinesis event. At the end of liver stage (LS) development, merozoites are packed into merosomes and released into the bloodstream. They are then liberated and infect red blood cells to again produce merozoites by schizogony for the erythrocytic stage of the life cycle. Although parasite LS and asexual blood stage (ABS) differ in many respects, important similarities exist between the two. This review focuses on the cell division of Plasmodium parasite LS in comparison with other life cycle stages especially the parasite blood stage.</description><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cytokinesis</subject><subject>Deoxyribonucleic acid</subject><subject>Developmental stages</subject><subject>DNA</subject><subject>DNA biosynthesis</subject><subject>DNA replication</subject><subject>Erythrocytes</subject><subject>Exocrine glands</subject><subject>Gene expression</subject><subject>Genetic engineering</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Hepatocytes</subject><subject>Kinases</subject><subject>Life Cycle Stages</subject><subject>Life cycles</subject><subject>Liver</subject><subject>Liver - parasitology</subject><subject>Medicine and Health Sciences</subject><subject>Merozoites</subject><subject>Mosquitoes</subject><subject>Organelles</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Plasmodium</subject><subject>Plasmodium - 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Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication within the host. Successfully invaded sporozoites undergo a massive replication and growth involving asynchronous DNA replication and division that results in the generation of tens of thousands or even hundreds of thousands of merozoites depending on the Plasmodium species. The generation of a high number of daughter parasites requires biogenesis and segregation of organelles to finally reach a relatively synchronous cytokinesis event. At the end of liver stage (LS) development, merozoites are packed into merosomes and released into the bloodstream. They are then liberated and infect red blood cells to again produce merozoites by schizogony for the erythrocytic stage of the life cycle. Although parasite LS and asexual blood stage (ABS) differ in many respects, important similarities exist between the two. 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| subjects | Animals Biology and Life Sciences Blood Blood cells Cell cycle Cell division Cytokinesis Deoxyribonucleic acid Developmental stages DNA DNA biosynthesis DNA replication Erythrocytes Exocrine glands Gene expression Genetic engineering Genomes Health aspects Hepatocytes Kinases Life Cycle Stages Life cycles Liver Liver - parasitology Medicine and Health Sciences Merozoites Mosquitoes Organelles Parasites Parasitic diseases Plasmodium Plasmodium - physiology Prevention Proteins Replication Review Risk factors Schizogony Skin Sporozoites Vertebrates |
| title | Same, same but different: Exploring Plasmodium cell division during liver stage development |
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