Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX

The ability of the cyclodextrin-oxime construct 6-OxP-CD to bind and degrade the nerve agents Cyclosarin (GF), Soman (GD) and S-[2-[Di(propan-2-yl)amino]ethyl] O-ethyl methylphosphonothioate (VX) has been studied using 31P-nuclear magnetic resonance (NMR) under physiological conditions. While 6-OxP-...

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Veröffentlicht in:	PloS one 2023-03, Vol.18 (3), p.e0283181-e0283181
Hauptverfasser:	Lau, Edmond Y, Enright, Heather A, Lao, Victoria, Malfatti, Michael A, Mayer, Brian P, Williams, Audrey M, Valdez, Carlos A
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Analysis Assassinations & assassination attempts Biological & chemical weapons Biology and Life Sciences Chemical warfare Chemical Warfare Agents chemistry Chromatography Computer and Information Sciences Computer applications Conformation Congeners Cyclodextrin Cyclodextrins Degradation Evaluation Forensic sciences Functional groups Gases, Asphyxiating and poisonous Inclusion complexes Laboratories Magnetic resonance Mathematical analysis Medical Countermeasures Medicine and Health Sciences Molecular dynamics Molecular Dynamics Simulation nerve agent Nerve Agents Nerve gas Nerves Neutralization NMR Nuclear magnetic resonance Organophosphorus Compounds - chemistry Orientation Oximes Phosphorus Physical Sciences Poisoning Properties Research and Analysis Methods Simulation Sodium Soman War use
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