Impact of early nutrition and feeding route on clinical outcomes of neurocritically ill patients
Early proper nutritional support is important to critically ill patients. Nutritional support is also associated with clinical outcomes of neurocritically ill patients. We investigate whether early nutrition is associated with clinical outcomes in neurocritically ill patients. This was a retrospecti...
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| creator | Choi, Young Kyun Kim, Hyun-Jung Ahn, Joonghyun Ryu, Jeong-Am |
| description | Early proper nutritional support is important to critically ill patients. Nutritional support is also associated with clinical outcomes of neurocritically ill patients. We investigate whether early nutrition is associated with clinical outcomes in neurocritically ill patients. This was a retrospective, single-center, observational study including neurosurgical patients who were admitted to the intensive care unit (ICU) from January 2013 to December 2019. Patients who started enteral nutrition or parenteral nutrition within 72 hours after ICU admission were defined as the early nutrition group. The primary endpoint was in-hospital mortality. The secondary endpoint was an infectious complication. Propensity score matching (PSM) and propensity score weighting overlap weights (PSOW) were used to control selection bias and confounding factors. Among 1,353 patients, early nutrition was performed in 384 (28.4%) patients: 152 (11.2%) early enteral nutrition (EEN) and 232 (17.1%) early parenteral nutrition (EPN). In the overall study population, the rate of in-hospital mortality was higher in patients with late nutrition than in those with early nutrition (P0.05). In the overall study population, EEN patients had a low rate of in-hospital mortality and infectious complications compared with those with EPN and late nutrition (P0.05), but EEN was significantly associated with in-hospital mortality and infectious complications (all P |
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Nutritional support is also associated with clinical outcomes of neurocritically ill patients. We investigate whether early nutrition is associated with clinical outcomes in neurocritically ill patients. This was a retrospective, single-center, observational study including neurosurgical patients who were admitted to the intensive care unit (ICU) from January 2013 to December 2019. Patients who started enteral nutrition or parenteral nutrition within 72 hours after ICU admission were defined as the early nutrition group. The primary endpoint was in-hospital mortality. The secondary endpoint was an infectious complication. Propensity score matching (PSM) and propensity score weighting overlap weights (PSOW) were used to control selection bias and confounding factors. Among 1,353 patients, early nutrition was performed in 384 (28.4%) patients: 152 (11.2%) early enteral nutrition (EEN) and 232 (17.1%) early parenteral nutrition (EPN). In the overall study population, the rate of in-hospital mortality was higher in patients with late nutrition than in those with early nutrition (P<0.001). However, there was no significant difference in in-hospital mortality and infectious complications incidence between the late and the early nutrition groups in the PSM and PSOW adjusted population (all P>0.05). In the overall study population, EEN patients had a low rate of in-hospital mortality and infectious complications compared with those with EPN and late nutrition (P<0.001 and P = 0.001, respectively). In the multivariable analysis of the overall, PSM adjusted, and PSOW adjusted population, there was no significant association between early nutrition and in-hospital mortality and infectious complications (all P>0.05), but EEN was significantly associated with in-hospital mortality and infectious complications (all P<0.05). Eventually, early enteral nutrition may reduce the risk of in-hospital mortality and infectious complications in neurocritically ill patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0283593</identifier><identifier>PMID: 36952527</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Bias ; Biology and Life Sciences ; Care and treatment ; Clinical outcomes ; Complications ; Critical Illness - therapy ; Critically ill ; Data warehouses ; Diagnosis ; Enteral feeding ; Enteral Nutrition ; Food and nutrition ; Glasgow Coma Scale ; Health aspects ; Humans ; Intensive care ; Intensive Care Units ; Intracranial pressure ; Length of Stay ; Malnutrition ; Medical prognosis ; Medical records ; Medicine and Health Sciences ; Mortality ; Neurologic manifestations of general diseases ; Neurosurgery ; Nosocomial infections ; Nutrition ; Nutritional Status ; Nutritional Support ; Parenteral Nutrition ; Patients ; Physiology ; Population studies ; Prevention ; Renal replacement therapy ; Retrospective Studies ; Risk factors ; Risk reduction ; Traumatic brain injury ; Tube feeding ; Variables</subject><ispartof>PloS one, 2023-03, Vol.18 (3), p.e0283593-e0283593</ispartof><rights>Copyright: © 2023 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Choi et al 2023 Choi et al</rights><rights>2023 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-6637728ec172aa3a9012d3ac414a255606060a75a3ba50611aa2e2dafd2091403</citedby><cites>FETCH-LOGICAL-c693t-6637728ec172aa3a9012d3ac414a255606060a75a3ba50611aa2e2dafd2091403</cites><orcidid>0000-0003-1705-848X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035931/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035931/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36952527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cinotti, Raphael</contributor><creatorcontrib>Choi, Young Kyun</creatorcontrib><creatorcontrib>Kim, Hyun-Jung</creatorcontrib><creatorcontrib>Ahn, Joonghyun</creatorcontrib><creatorcontrib>Ryu, Jeong-Am</creatorcontrib><title>Impact of early nutrition and feeding route on clinical outcomes of neurocritically ill patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Early proper nutritional support is important to critically ill patients. Nutritional support is also associated with clinical outcomes of neurocritically ill patients. We investigate whether early nutrition is associated with clinical outcomes in neurocritically ill patients. This was a retrospective, single-center, observational study including neurosurgical patients who were admitted to the intensive care unit (ICU) from January 2013 to December 2019. Patients who started enteral nutrition or parenteral nutrition within 72 hours after ICU admission were defined as the early nutrition group. The primary endpoint was in-hospital mortality. The secondary endpoint was an infectious complication. Propensity score matching (PSM) and propensity score weighting overlap weights (PSOW) were used to control selection bias and confounding factors. Among 1,353 patients, early nutrition was performed in 384 (28.4%) patients: 152 (11.2%) early enteral nutrition (EEN) and 232 (17.1%) early parenteral nutrition (EPN). In the overall study population, the rate of in-hospital mortality was higher in patients with late nutrition than in those with early nutrition (P<0.001). However, there was no significant difference in in-hospital mortality and infectious complications incidence between the late and the early nutrition groups in the PSM and PSOW adjusted population (all P>0.05). In the overall study population, EEN patients had a low rate of in-hospital mortality and infectious complications compared with those with EPN and late nutrition (P<0.001 and P = 0.001, respectively). In the multivariable analysis of the overall, PSM adjusted, and PSOW adjusted population, there was no significant association between early nutrition and in-hospital mortality and infectious complications (all P>0.05), but EEN was significantly associated with in-hospital mortality and infectious complications (all P<0.05). Eventually, early enteral nutrition may reduce the risk of in-hospital mortality and infectious complications in neurocritically ill patients.</description><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Clinical outcomes</subject><subject>Complications</subject><subject>Critical Illness - therapy</subject><subject>Critically ill</subject><subject>Data warehouses</subject><subject>Diagnosis</subject><subject>Enteral feeding</subject><subject>Enteral Nutrition</subject><subject>Food and nutrition</subject><subject>Glasgow Coma Scale</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intensive care</subject><subject>Intensive Care Units</subject><subject>Intracranial pressure</subject><subject>Length of Stay</subject><subject>Malnutrition</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Neurologic manifestations of general diseases</subject><subject>Neurosurgery</subject><subject>Nosocomial infections</subject><subject>Nutrition</subject><subject>Nutritional Status</subject><subject>Nutritional Support</subject><subject>Parenteral Nutrition</subject><subject>Patients</subject><subject>Physiology</subject><subject>Population studies</subject><subject>Prevention</subject><subject>Renal replacement therapy</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Traumatic brain injury</subject><subject>Tube 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of early nutrition and feeding route on clinical outcomes of neurocritically ill patients</title><author>Choi, Young Kyun ; Kim, Hyun-Jung ; Ahn, Joonghyun ; Ryu, Jeong-Am</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-6637728ec172aa3a9012d3ac414a255606060a75a3ba50611aa2e2dafd2091403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bias</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Clinical outcomes</topic><topic>Complications</topic><topic>Critical Illness - therapy</topic><topic>Critically ill</topic><topic>Data warehouses</topic><topic>Diagnosis</topic><topic>Enteral feeding</topic><topic>Enteral Nutrition</topic><topic>Food and nutrition</topic><topic>Glasgow Coma Scale</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Intensive care</topic><topic>Intensive Care Units</topic><topic>Intracranial pressure</topic><topic>Length of Stay</topic><topic>Malnutrition</topic><topic>Medical prognosis</topic><topic>Medical records</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Neurologic manifestations of general diseases</topic><topic>Neurosurgery</topic><topic>Nosocomial infections</topic><topic>Nutrition</topic><topic>Nutritional Status</topic><topic>Nutritional Support</topic><topic>Parenteral Nutrition</topic><topic>Patients</topic><topic>Physiology</topic><topic>Population studies</topic><topic>Prevention</topic><topic>Renal replacement therapy</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Risk reduction</topic><topic>Traumatic brain injury</topic><topic>Tube feeding</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Young Kyun</creatorcontrib><creatorcontrib>Kim, Hyun-Jung</creatorcontrib><creatorcontrib>Ahn, 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Raphael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of early nutrition and feeding route on clinical outcomes of neurocritically ill patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-03-23</date><risdate>2023</risdate><volume>18</volume><issue>3</issue><spage>e0283593</spage><epage>e0283593</epage><pages>e0283593-e0283593</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Early proper nutritional support is important to critically ill patients. Nutritional support is also associated with clinical outcomes of neurocritically ill patients. We investigate whether early nutrition is associated with clinical outcomes in neurocritically ill patients. This was a retrospective, single-center, observational study including neurosurgical patients who were admitted to the intensive care unit (ICU) from January 2013 to December 2019. Patients who started enteral nutrition or parenteral nutrition within 72 hours after ICU admission were defined as the early nutrition group. The primary endpoint was in-hospital mortality. The secondary endpoint was an infectious complication. Propensity score matching (PSM) and propensity score weighting overlap weights (PSOW) were used to control selection bias and confounding factors. Among 1,353 patients, early nutrition was performed in 384 (28.4%) patients: 152 (11.2%) early enteral nutrition (EEN) and 232 (17.1%) early parenteral nutrition (EPN). In the overall study population, the rate of in-hospital mortality was higher in patients with late nutrition than in those with early nutrition (P<0.001). However, there was no significant difference in in-hospital mortality and infectious complications incidence between the late and the early nutrition groups in the PSM and PSOW adjusted population (all P>0.05). In the overall study population, EEN patients had a low rate of in-hospital mortality and infectious complications compared with those with EPN and late nutrition (P<0.001 and P = 0.001, respectively). In the multivariable analysis of the overall, PSM adjusted, and PSOW adjusted population, there was no significant association between early nutrition and in-hospital mortality and infectious complications (all P>0.05), but EEN was significantly associated with in-hospital mortality and infectious complications (all P<0.05). Eventually, early enteral nutrition may reduce the risk of in-hospital mortality and infectious complications in neurocritically ill patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36952527</pmid><doi>10.1371/journal.pone.0283593</doi><tpages>e0283593</tpages><orcidid>https://orcid.org/0000-0003-1705-848X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bias Biology and Life Sciences Care and treatment Clinical outcomes Complications Critical Illness - therapy Critically ill Data warehouses Diagnosis Enteral feeding Enteral Nutrition Food and nutrition Glasgow Coma Scale Health aspects Humans Intensive care Intensive Care Units Intracranial pressure Length of Stay Malnutrition Medical prognosis Medical records Medicine and Health Sciences Mortality Neurologic manifestations of general diseases Neurosurgery Nosocomial infections Nutrition Nutritional Status Nutritional Support Parenteral Nutrition Patients Physiology Population studies Prevention Renal replacement therapy Retrospective Studies Risk factors Risk reduction Traumatic brain injury Tube feeding Variables |
| title | Impact of early nutrition and feeding route on clinical outcomes of neurocritically ill patients |
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