Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand
Borrelia miyamotoi is a relapsing fever spirochete that shares the same vector as Lyme disease causing Borrelia. This epidemiological study of B. miyamotoi was conducted in rodent reservoirs, tick vectors and human populations simultaneously. A total of 640 rodents and 43 ticks were collected from P...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2023-02, Vol.17 (2), p.e0011159-e0011159 |
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| creator | Takhampunya, Ratree Longkunan, Asma Somchaimongkol, Sakbuncha Youngdech, Nittayaphon Chanarat, Nitima Sakolvaree, Jira Tippayachai, Bousaraporn Promsathaporn, Sommai Phanpheuch, Bhakdee Poole-Smith, Betty K McCardle, Patrick W Lindroth, Erica J |
| description | Borrelia miyamotoi is a relapsing fever spirochete that shares the same vector as Lyme disease causing Borrelia. This epidemiological study of B. miyamotoi was conducted in rodent reservoirs, tick vectors and human populations simultaneously. A total of 640 rodents and 43 ticks were collected from Phop Phra district, Tak province, Thailand. The prevalence rate for all Borrelia species was 2.3% and for B. miyamotoi was 1.1% in the rodent population, while the prevalence rate was quite high in ticks collected from rodents with an infection rate of 14.5% (95% CI: 6.3-27.6%). Borrelia miyamotoi was detected in Ixodes granulatus collected from Mus caroli and Berylmys bowersi, and was also detected in several rodent species (Bandicota indica, Mus spp., and Leopoldamys sabanus) that live in a cultivated land, increasing the risk of human exposure. Phylogenetic analysis revealed that the B. miyamotoi isolates detected in rodents and I. granulatus ticks in this study were similar to isolates detected in European countries. Further investigation was conducted to determine the serological reactivity to B. miyamotoi in human samples received from Phop Phra hospital, Tak province and in rodents captured from Phop Phra district using an in-house, direct enzyme-linked immunosorbent assay (ELISA) assay with B. miyamotoi recombinant glycerophosphodiester-phosphodiesterase (rGlpQ) protein as coated antigen. The results showed that 17.9% (15/84) of human patients and 9.0% (41/456) of captured rodents had serological reactivity to B. miyamotoi rGlpQ protein in the study area. While a low level of IgG antibody titers (100-200) was observed in the majority of seroreactive samples, higher titers (400-1,600) were also detected in both humans and rodents. This study provides the first evidence of B. miyamotoi exposure in human and rodent populations in Thailand and the possible roles of local rodent species and Ixodes granulatus tick in its enzootic transmission cycle in nature. |
| doi_str_mv | 10.1371/journal.pntd.0011159 |
| format | Article |
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This epidemiological study of B. miyamotoi was conducted in rodent reservoirs, tick vectors and human populations simultaneously. A total of 640 rodents and 43 ticks were collected from Phop Phra district, Tak province, Thailand. The prevalence rate for all Borrelia species was 2.3% and for B. miyamotoi was 1.1% in the rodent population, while the prevalence rate was quite high in ticks collected from rodents with an infection rate of 14.5% (95% CI: 6.3-27.6%). Borrelia miyamotoi was detected in Ixodes granulatus collected from Mus caroli and Berylmys bowersi, and was also detected in several rodent species (Bandicota indica, Mus spp., and Leopoldamys sabanus) that live in a cultivated land, increasing the risk of human exposure. Phylogenetic analysis revealed that the B. miyamotoi isolates detected in rodents and I. granulatus ticks in this study were similar to isolates detected in European countries. Further investigation was conducted to determine the serological reactivity to B. miyamotoi in human samples received from Phop Phra hospital, Tak province and in rodents captured from Phop Phra district using an in-house, direct enzyme-linked immunosorbent assay (ELISA) assay with B. miyamotoi recombinant glycerophosphodiester-phosphodiesterase (rGlpQ) protein as coated antigen. The results showed that 17.9% (15/84) of human patients and 9.0% (41/456) of captured rodents had serological reactivity to B. miyamotoi rGlpQ protein in the study area. While a low level of IgG antibody titers (100-200) was observed in the majority of seroreactive samples, higher titers (400-1,600) were also detected in both humans and rodents. This study provides the first evidence of B. miyamotoi exposure in human and rodent populations in Thailand and the possible roles of local rodent species and Ixodes granulatus tick in its enzootic transmission cycle in nature.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0011159</identifier><identifier>PMID: 36809255</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antigens ; Arachnids ; Biology and Life Sciences ; Borrelia ; Borrelia miyamotoi ; Cladistics ; Cultivated lands ; Distribution ; ELISA ; Enzyme-linked immunosorbent assay ; Epidemiology ; Fever ; Granulation ; Host-parasite relationships ; Human populations ; Humans ; IgG antibody ; Immunoglobulin G ; Ixodes ; Ixodes granulatus ; Laboratory animals ; Low level ; Lyme disease ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Murinae ; Pathogens ; Patients ; People and Places ; Phylogenetics ; Phylogeny ; Populations ; Proteins ; Recombinants ; Relapsing Fever ; Rodents ; Samples ; Spirochetes ; Thailand ; Tick-borne diseases ; Ticks ; Transmission ; Tropical diseases ; Vector-borne diseases ; Vectors ; Zoonoses</subject><ispartof>PLoS neglected tropical diseases, 2023-02, Vol.17 (2), p.e0011159-e0011159</ispartof><rights>Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-c3f3361826ca576ce6757f0b33f095a7ea094460ef6a821f7ddef11b6d96c2673</citedby><cites>FETCH-LOGICAL-c624t-c3f3361826ca576ce6757f0b33f095a7ea094460ef6a821f7ddef11b6d96c2673</cites><orcidid>0000-0001-5136-3547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983830/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983830/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36809255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Guo, Wen-Ping</contributor><creatorcontrib>Takhampunya, Ratree</creatorcontrib><creatorcontrib>Longkunan, Asma</creatorcontrib><creatorcontrib>Somchaimongkol, Sakbuncha</creatorcontrib><creatorcontrib>Youngdech, Nittayaphon</creatorcontrib><creatorcontrib>Chanarat, Nitima</creatorcontrib><creatorcontrib>Sakolvaree, Jira</creatorcontrib><creatorcontrib>Tippayachai, Bousaraporn</creatorcontrib><creatorcontrib>Promsathaporn, Sommai</creatorcontrib><creatorcontrib>Phanpheuch, Bhakdee</creatorcontrib><creatorcontrib>Poole-Smith, Betty K</creatorcontrib><creatorcontrib>McCardle, Patrick W</creatorcontrib><creatorcontrib>Lindroth, Erica J</creatorcontrib><title>Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Borrelia miyamotoi is a relapsing fever spirochete that shares the same vector as Lyme disease causing Borrelia. This epidemiological study of B. miyamotoi was conducted in rodent reservoirs, tick vectors and human populations simultaneously. A total of 640 rodents and 43 ticks were collected from Phop Phra district, Tak province, Thailand. The prevalence rate for all Borrelia species was 2.3% and for B. miyamotoi was 1.1% in the rodent population, while the prevalence rate was quite high in ticks collected from rodents with an infection rate of 14.5% (95% CI: 6.3-27.6%). Borrelia miyamotoi was detected in Ixodes granulatus collected from Mus caroli and Berylmys bowersi, and was also detected in several rodent species (Bandicota indica, Mus spp., and Leopoldamys sabanus) that live in a cultivated land, increasing the risk of human exposure. Phylogenetic analysis revealed that the B. miyamotoi isolates detected in rodents and I. granulatus ticks in this study were similar to isolates detected in European countries. Further investigation was conducted to determine the serological reactivity to B. miyamotoi in human samples received from Phop Phra hospital, Tak province and in rodents captured from Phop Phra district using an in-house, direct enzyme-linked immunosorbent assay (ELISA) assay with B. miyamotoi recombinant glycerophosphodiester-phosphodiesterase (rGlpQ) protein as coated antigen. The results showed that 17.9% (15/84) of human patients and 9.0% (41/456) of captured rodents had serological reactivity to B. miyamotoi rGlpQ protein in the study area. While a low level of IgG antibody titers (100-200) was observed in the majority of seroreactive samples, higher titers (400-1,600) were also detected in both humans and rodents. This study provides the first evidence of B. miyamotoi exposure in human and rodent populations in Thailand and the possible roles of local rodent species and Ixodes granulatus tick in its enzootic transmission cycle in nature.</description><subject>Animals</subject><subject>Antigens</subject><subject>Arachnids</subject><subject>Biology and Life Sciences</subject><subject>Borrelia</subject><subject>Borrelia miyamotoi</subject><subject>Cladistics</subject><subject>Cultivated lands</subject><subject>Distribution</subject><subject>ELISA</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epidemiology</subject><subject>Fever</subject><subject>Granulation</subject><subject>Host-parasite relationships</subject><subject>Human populations</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immunoglobulin G</subject><subject>Ixodes</subject><subject>Ixodes granulatus</subject><subject>Laboratory animals</subject><subject>Low level</subject><subject>Lyme 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miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand</title><author>Takhampunya, Ratree ; Longkunan, Asma ; Somchaimongkol, Sakbuncha ; Youngdech, Nittayaphon ; Chanarat, Nitima ; Sakolvaree, Jira ; Tippayachai, Bousaraporn ; Promsathaporn, Sommai ; Phanpheuch, Bhakdee ; Poole-Smith, Betty K ; McCardle, Patrick W ; Lindroth, Erica J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-c3f3361826ca576ce6757f0b33f095a7ea094460ef6a821f7ddef11b6d96c2673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Arachnids</topic><topic>Biology and Life Sciences</topic><topic>Borrelia</topic><topic>Borrelia miyamotoi</topic><topic>Cladistics</topic><topic>Cultivated lands</topic><topic>Distribution</topic><topic>ELISA</topic><topic>Enzyme-linked immunosorbent 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This epidemiological study of B. miyamotoi was conducted in rodent reservoirs, tick vectors and human populations simultaneously. A total of 640 rodents and 43 ticks were collected from Phop Phra district, Tak province, Thailand. The prevalence rate for all Borrelia species was 2.3% and for B. miyamotoi was 1.1% in the rodent population, while the prevalence rate was quite high in ticks collected from rodents with an infection rate of 14.5% (95% CI: 6.3-27.6%). Borrelia miyamotoi was detected in Ixodes granulatus collected from Mus caroli and Berylmys bowersi, and was also detected in several rodent species (Bandicota indica, Mus spp., and Leopoldamys sabanus) that live in a cultivated land, increasing the risk of human exposure. Phylogenetic analysis revealed that the B. miyamotoi isolates detected in rodents and I. granulatus ticks in this study were similar to isolates detected in European countries. Further investigation was conducted to determine the serological reactivity to B. miyamotoi in human samples received from Phop Phra hospital, Tak province and in rodents captured from Phop Phra district using an in-house, direct enzyme-linked immunosorbent assay (ELISA) assay with B. miyamotoi recombinant glycerophosphodiester-phosphodiesterase (rGlpQ) protein as coated antigen. The results showed that 17.9% (15/84) of human patients and 9.0% (41/456) of captured rodents had serological reactivity to B. miyamotoi rGlpQ protein in the study area. While a low level of IgG antibody titers (100-200) was observed in the majority of seroreactive samples, higher titers (400-1,600) were also detected in both humans and rodents. This study provides the first evidence of B. miyamotoi exposure in human and rodent populations in Thailand and the possible roles of local rodent species and Ixodes granulatus tick in its enzootic transmission cycle in nature.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36809255</pmid><doi>10.1371/journal.pntd.0011159</doi><orcidid>https://orcid.org/0000-0001-5136-3547</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2023-02, Vol.17 (2), p.e0011159-e0011159 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2787643945 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antigens Arachnids Biology and Life Sciences Borrelia Borrelia miyamotoi Cladistics Cultivated lands Distribution ELISA Enzyme-linked immunosorbent assay Epidemiology Fever Granulation Host-parasite relationships Human populations Humans IgG antibody Immunoglobulin G Ixodes Ixodes granulatus Laboratory animals Low level Lyme disease Medical research Medicine and Health Sciences Medicine, Experimental Murinae Pathogens Patients People and Places Phylogenetics Phylogeny Populations Proteins Recombinants Relapsing Fever Rodents Samples Spirochetes Thailand Tick-borne diseases Ticks Transmission Tropical diseases Vector-borne diseases Vectors Zoonoses |
| title | Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T15%3A21%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Borrelia%20miyamotoi%20a%20neglected%20tick-borne%20relapsing%20fever%20spirochete%20in%20Thailand&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Takhampunya,%20Ratree&rft.date=2023-02-01&rft.volume=17&rft.issue=2&rft.spage=e0011159&rft.epage=e0011159&rft.pages=e0011159-e0011159&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0011159&rft_dat=%3Cgale_plos_%3EA739405277%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2787643945&rft_id=info:pmid/36809255&rft_galeid=A739405277&rft_doaj_id=oai_doaj_org_article_1b5f61890b6e4798aef88e872109eaa2&rfr_iscdi=true |