Type II endometrial cancer: Incidence, overall and disease-free survival in Martinique
In Martinique, about 33 new cases of endometrial cancer are diagnosed per year with a high mortality rate (world standardised rate of 4.9/100,000 versus 2.3/100,000 in mainland France). The present study aimed to determine the incidence and mortality of type I and type II endometrial cancers (ECs),...
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| description | In Martinique, about 33 new cases of endometrial cancer are diagnosed per year with a high mortality rate (world standardised rate of 4.9/100,000 versus 2.3/100,000 in mainland France). The present study aimed to determine the incidence and mortality of type I and type II endometrial cancers (ECs), their overall survival (OS) and disease-free survival (DFS) between 2012 and 2016.
This retrospective observational cohort study used data from the Martinique Cancer Registry (MCR). 191 patients with corpus uterine cancer were extracted between 2012 and 2016. Patients with either endometrioid endometrial carcinoma (EEC), uterine papillary serous carcinomas (UPSC), uterine clear cell carcinomas (UCCC) or uterine carcinosarcomas (UCS) were included. All other uterine cancers were excluded.
Among the 163 included patients, 97 (60%) were type I and 66 (40%) were type II. The standardized incidence rate is 4.50/100,000 for type I vs. 2.66/100,000 for type II. Three years DFS for all types, type I and type II was 81.5% [74.2-86.9], 84.9% [75.4-91] and 76.7% [63.8-85.5] respectively. The five-years OS for all types, type I and type II was 47.0% [38.9-54.7] vs. 58.8% [47.3-68.5] vs. 22.8% [15.0-37.7] respectively.
In Martinique, we report a high proportion of type II ECs, which has a poor prognosis with few treatment options. |
| doi_str_mv | 10.1371/journal.pone.0278757 |
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This retrospective observational cohort study used data from the Martinique Cancer Registry (MCR). 191 patients with corpus uterine cancer were extracted between 2012 and 2016. Patients with either endometrioid endometrial carcinoma (EEC), uterine papillary serous carcinomas (UPSC), uterine clear cell carcinomas (UCCC) or uterine carcinosarcomas (UCS) were included. All other uterine cancers were excluded.
Among the 163 included patients, 97 (60%) were type I and 66 (40%) were type II. The standardized incidence rate is 4.50/100,000 for type I vs. 2.66/100,000 for type II. Three years DFS for all types, type I and type II was 81.5% [74.2-86.9], 84.9% [75.4-91] and 76.7% [63.8-85.5] respectively. The five-years OS for all types, type I and type II was 47.0% [38.9-54.7] vs. 58.8% [47.3-68.5] vs. 22.8% [15.0-37.7] respectively.
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This retrospective observational cohort study used data from the Martinique Cancer Registry (MCR). 191 patients with corpus uterine cancer were extracted between 2012 and 2016. Patients with either endometrioid endometrial carcinoma (EEC), uterine papillary serous carcinomas (UPSC), uterine clear cell carcinomas (UCCC) or uterine carcinosarcomas (UCS) were included. All other uterine cancers were excluded.
Among the 163 included patients, 97 (60%) were type I and 66 (40%) were type II. The standardized incidence rate is 4.50/100,000 for type I vs. 2.66/100,000 for type II. Three years DFS for all types, type I and type II was 81.5% [74.2-86.9], 84.9% [75.4-91] and 76.7% [63.8-85.5] respectively. The five-years OS for all types, type I and type II was 47.0% [38.9-54.7] vs. 58.8% [47.3-68.5] vs. 22.8% [15.0-37.7] respectively.
In Martinique, we report a high proportion of type II ECs, which has a poor prognosis with few treatment options.</description><subject>Age</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Disease-Free Survival</subject><subject>Distribution</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - metabolism</subject><subject>Endometrium</subject><subject>Estimates</subject><subject>Female</subject><subject>Histology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Life Sciences</subject><subject>Martinique - epidemiology</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>Obesity</subject><subject>Observational studies</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>People and places</subject><subject>Population</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Tumors</subject><subject>Uterine cancer</subject><subject>Uterine Neoplasms - 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The present study aimed to determine the incidence and mortality of type I and type II endometrial cancers (ECs), their overall survival (OS) and disease-free survival (DFS) between 2012 and 2016.
This retrospective observational cohort study used data from the Martinique Cancer Registry (MCR). 191 patients with corpus uterine cancer were extracted between 2012 and 2016. Patients with either endometrioid endometrial carcinoma (EEC), uterine papillary serous carcinomas (UPSC), uterine clear cell carcinomas (UCCC) or uterine carcinosarcomas (UCS) were included. All other uterine cancers were excluded.
Among the 163 included patients, 97 (60%) were type I and 66 (40%) were type II. The standardized incidence rate is 4.50/100,000 for type I vs. 2.66/100,000 for type II. Three years DFS for all types, type I and type II was 81.5% [74.2-86.9], 84.9% [75.4-91] and 76.7% [63.8-85.5] respectively. The five-years OS for all types, type I and type II was 47.0% [38.9-54.7] vs. 58.8% [47.3-68.5] vs. 22.8% [15.0-37.7] respectively.
In Martinique, we report a high proportion of type II ECs, which has a poor prognosis with few treatment options.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36928660</pmid><doi>10.1371/journal.pone.0278757</doi><tpages>e0278757</tpages><orcidid>https://orcid.org/0000-0001-7580-2997</orcidid><orcidid>https://orcid.org/0000-0003-0098-2078</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2787569078 |
| source | MEDLINE; PLoS_OA刊; EZB-FREE-00999 freely available EZB journals; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry |
| subjects | Age Analysis Biology and Life Sciences Body mass index Cancer Cancer therapies Carcinoma Carcinoma, Endometrioid - pathology Development and progression Diabetes Disease-Free Survival Distribution Endometrial cancer Endometrial Neoplasms - metabolism Endometrium Estimates Female Histology Humans Incidence Life Sciences Martinique - epidemiology Medical diagnosis Medical prognosis Medical records Medicine and Health Sciences Mortality Mutation Neoplasm Staging Obesity Observational studies Patient outcomes Patients People and places Population Prognosis Retrospective Studies Risk factors Survival Survival analysis Tumors Uterine cancer Uterine Neoplasms - pathology Womens health |
| title | Type II endometrial cancer: Incidence, overall and disease-free survival in Martinique |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A15%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Type%20II%20endometrial%20cancer:%20Incidence,%20overall%20and%20disease-free%20survival%20in%20Martinique&rft.jtitle=PloS%20one&rft.au=Ebring,%20Coralie&rft.date=2023-03-16&rft.volume=18&rft.issue=3&rft.spage=e0278757&rft.epage=e0278757&rft.pages=e0278757-e0278757&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0278757&rft_dat=%3Cgale_plos_%3EA741535668%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2787569078&rft_id=info:pmid/36928660&rft_galeid=A741535668&rft_doaj_id=oai_doaj_org_article_48d47811691948c5907f8e8ed916ea34&rfr_iscdi=true |