Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study
Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS. This was an observational study. A total of 107 children and adol...
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| Veröffentlicht in: | PloS one 2023-03, Vol.18 (3), p.e0281381-e0281381 |
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| creator | Cura-Esquivel, Idalia Perales-Quintana, Marlene Marisol Torres-González, Liliana Guzmán-Avilán, Katia Muñoz-Espinosa, Linda Cordero-Pérez, Paula |
| description | Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS.
This was an observational study. A total of 107 children and adolescents aged 6-18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios.
Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDL-C ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled.
Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity. |
| doi_str_mv | 10.1371/journal.pone.0281381 |
| format | Article |
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This was an observational study. A total of 107 children and adolescents aged 6-18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios.
Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDL-C ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled.
Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0281381</identifier><identifier>PMID: 36920931</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adipokines ; Adolescent ; Adolescents ; Adult ; Analysis ; Analysis and chemistry ; Biology and Life Sciences ; Blood ; Blood pressure ; Body Mass Index ; Body weight ; Child ; Children ; Cholesterol ; Correlation ; Cross-Sectional Studies ; Cytokines ; Development and progression ; Diagnosis ; Distribution ; Enzymes ; Health aspects ; High density lipoprotein ; Humans ; Hypertension ; Immunoassay ; Inflammation ; Laboratory tests ; Leptin ; Lipoproteins ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic syndrome X ; Monocyte chemoattractant protein 1 ; Obesity ; Obesity in children ; Overweight ; Overweight - complications ; Pediatric Obesity - complications ; Pediatrics ; Plasminogen Activator Inhibitor 1 ; Proteins ; Ratios ; Sensitivity ; Teenagers ; Triglycerides ; Tumor necrosis factor-TNF ; Type 2 diabetes</subject><ispartof>PloS one, 2023-03, Vol.18 (3), p.e0281381-e0281381</ispartof><rights>Copyright: © 2023 Cura–Esquivel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Cura–Esquivel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Cura–Esquivel et al 2023 Cura–Esquivel et al</rights><rights>2023 Cura–Esquivel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-20cc91c661365d94334b2941f5ce7a1b2d49dcb3225fcb52d4ccb29cbf00b31b3</citedby><cites>FETCH-LOGICAL-c693t-20cc91c661365d94334b2941f5ce7a1b2d49dcb3225fcb52d4ccb29cbf00b31b3</cites><orcidid>0000-0001-7747-8895 ; 0000-0002-4080-1748</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016645/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016645/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36920931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bello-Chavolla, Omar Yaxmehen</contributor><creatorcontrib>Cura-Esquivel, Idalia</creatorcontrib><creatorcontrib>Perales-Quintana, Marlene Marisol</creatorcontrib><creatorcontrib>Torres-González, Liliana</creatorcontrib><creatorcontrib>Guzmán-Avilán, Katia</creatorcontrib><creatorcontrib>Muñoz-Espinosa, Linda</creatorcontrib><creatorcontrib>Cordero-Pérez, Paula</creatorcontrib><title>Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS.
This was an observational study. A total of 107 children and adolescents aged 6-18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios.
Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDL-C ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled.
Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity.</description><subject>Abdomen</subject><subject>Adipokines</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Analysis</subject><subject>Analysis and chemistry</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Child</subject><subject>Children</subject><subject>Cholesterol</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Distribution</subject><subject>Enzymes</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Immunoassay</subject><subject>Inflammation</subject><subject>Laboratory tests</subject><subject>Leptin</subject><subject>Lipoproteins</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Experimental</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic syndrome X</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Obesity</subject><subject>Obesity in children</subject><subject>Overweight</subject><subject>Overweight - complications</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatrics</subject><subject>Plasminogen Activator Inhibitor 1</subject><subject>Proteins</subject><subject>Ratios</subject><subject>Sensitivity</subject><subject>Teenagers</subject><subject>Triglycerides</subject><subject>Tumor 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inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study</title><author>Cura-Esquivel, Idalia ; Perales-Quintana, Marlene Marisol ; Torres-González, Liliana ; Guzmán-Avilán, Katia ; Muñoz-Espinosa, Linda ; Cordero-Pérez, Paula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-20cc91c661365d94334b2941f5ce7a1b2d49dcb3225fcb52d4ccb29cbf00b31b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdomen</topic><topic>Adipokines</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Analysis</topic><topic>Analysis and chemistry</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood pressure</topic><topic>Body Mass Index</topic><topic>Body 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one</jtitle><addtitle>PLoS One</addtitle><date>2023-03-15</date><risdate>2023</risdate><volume>18</volume><issue>3</issue><spage>e0281381</spage><epage>e0281381</epage><pages>e0281381-e0281381</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS.
This was an observational study. A total of 107 children and adolescents aged 6-18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios.
Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDL-C ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled.
Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36920931</pmid><doi>10.1371/journal.pone.0281381</doi><tpages>e0281381</tpages><orcidid>https://orcid.org/0000-0001-7747-8895</orcidid><orcidid>https://orcid.org/0000-0002-4080-1748</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-03, Vol.18 (3), p.e0281381-e0281381 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2787181133 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Adipokines Adolescent Adolescents Adult Analysis Analysis and chemistry Biology and Life Sciences Blood Blood pressure Body Mass Index Body weight Child Children Cholesterol Correlation Cross-Sectional Studies Cytokines Development and progression Diagnosis Distribution Enzymes Health aspects High density lipoprotein Humans Hypertension Immunoassay Inflammation Laboratory tests Leptin Lipoproteins Medical research Medicine and Health Sciences Medicine, Experimental Metabolic disorders Metabolic syndrome Metabolic Syndrome - complications Metabolic syndrome X Monocyte chemoattractant protein 1 Obesity Obesity in children Overweight Overweight - complications Pediatric Obesity - complications Pediatrics Plasminogen Activator Inhibitor 1 Proteins Ratios Sensitivity Teenagers Triglycerides Tumor necrosis factor-TNF Type 2 diabetes |
| title | Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T12%3A08%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic,%20inflammatory%20and%20adipokine%20differences%20on%20overweight/obese%20children%20with%20and%20without%20metabolic%20syndrome:%20A%20cross-sectional%20study&rft.jtitle=PloS%20one&rft.au=Cura-Esquivel,%20Idalia&rft.date=2023-03-15&rft.volume=18&rft.issue=3&rft.spage=e0281381&rft.epage=e0281381&rft.pages=e0281381-e0281381&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0281381&rft_dat=%3Cgale_plos_%3EA741362610%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2787181133&rft_id=info:pmid/36920931&rft_galeid=A741362610&rft_doaj_id=oai_doaj_org_article_b5a21623aa6d47a5aaef33d256db50f4&rfr_iscdi=true |