Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders
Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-...
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| Veröffentlicht in: | PloS one 2023-03, Vol.18 (3), p.e0282271-e0282271 |
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| creator | Waszczuk, Monika A Morozova, Olga Lhuillier, Elizabeth Docherty, Anna R Shabalin, Andrey A Yang, Xiaohua Carr, Melissa A Clouston, Sean A P Kotov, Roman Luft, Benjamin J |
| description | Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals.
Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates.
The asthma PRS was associated with severe COVID-19 category (odds ratio [OR] = 1.61, 95% confidence interval: 1.17-2.21) and more severe COVID-19 symptomatology (β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS (OR = 1.97, [1.26-3.07]) and the PRS for COVID-19 hospitalization (OR = 1.35, [1.01-1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity.
Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population. |
| doi_str_mv | 10.1371/journal.pone.0282271 |
| format | Article |
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Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates.
The asthma PRS was associated with severe COVID-19 category (odds ratio [OR] = 1.61, 95% confidence interval: 1.17-2.21) and more severe COVID-19 symptomatology (β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS (OR = 1.97, [1.26-3.07]) and the PRS for COVID-19 hospitalization (OR = 1.35, [1.01-1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity.
Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0282271</identifier><identifier>PMID: 36893177</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Allergic diseases ; Allergic reaction ; Allergy ; Asthma ; Asthma - diagnosis ; Asthma - genetics ; Asymptomatic ; Biology and Life Sciences ; Biomarkers ; Cardiovascular disease ; Coronary artery disease ; Coronary vessels ; Coronaviruses ; COVID-19 ; COVID-19 - genetics ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 ; Diagnosis ; Electronic health records ; Female ; Genetic factors ; Health risk assessment ; Heart diseases ; Hospitalization ; Humans ; Infections ; Laboratories ; Male ; Medical records ; Medicine and Health Sciences ; Nervous system ; Post traumatic stress disorder ; Respiratory diseases ; Risk Factors ; SARS-CoV-2 - genetics ; September 11 terrorist attacks-2001 ; Severe acute respiratory syndrome coronavirus 2 ; Variables ; Vein & artery diseases ; Viral diseases</subject><ispartof>PloS one, 2023-03, Vol.18 (3), p.e0282271-e0282271</ispartof><rights>Copyright: © 2023 Waszczuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Waszczuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Waszczuk et al 2023 Waszczuk et al</rights><rights>2023 Waszczuk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-29d411b991cc51fff113bf670fa204d37d481d74be7ffec2b95cb6e31a45c9a33</citedby><cites>FETCH-LOGICAL-c692t-29d411b991cc51fff113bf670fa204d37d481d74be7ffec2b95cb6e31a45c9a33</cites><orcidid>0000-0001-7139-7007 ; 0000-0002-0870-6628 ; 0000-0001-9008-7004</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997960/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997960/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36893177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhu, Zhaozhong</contributor><creatorcontrib>Waszczuk, Monika A</creatorcontrib><creatorcontrib>Morozova, Olga</creatorcontrib><creatorcontrib>Lhuillier, Elizabeth</creatorcontrib><creatorcontrib>Docherty, Anna R</creatorcontrib><creatorcontrib>Shabalin, Andrey A</creatorcontrib><creatorcontrib>Yang, Xiaohua</creatorcontrib><creatorcontrib>Carr, Melissa A</creatorcontrib><creatorcontrib>Clouston, Sean A P</creatorcontrib><creatorcontrib>Kotov, Roman</creatorcontrib><creatorcontrib>Luft, Benjamin J</creatorcontrib><title>Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals.
Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates.
The asthma PRS was associated with severe COVID-19 category (odds ratio [OR] = 1.61, 95% confidence interval: 1.17-2.21) and more severe COVID-19 symptomatology (β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS (OR = 1.97, [1.26-3.07]) and the PRS for COVID-19 hospitalization (OR = 1.35, [1.01-1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity.
Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.</description><subject>Allergic diseases</subject><subject>Allergic reaction</subject><subject>Allergy</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - genetics</subject><subject>Asymptomatic</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - genetics</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Diagnosis</subject><subject>Electronic health records</subject><subject>Female</subject><subject>Genetic factors</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Nervous system</subject><subject>Post traumatic stress disorder</subject><subject>Respiratory diseases</subject><subject>Risk Factors</subject><subject>SARS-CoV-2 - 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A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals.
Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates.
The asthma PRS was associated with severe COVID-19 category (odds ratio [OR] = 1.61, 95% confidence interval: 1.17-2.21) and more severe COVID-19 symptomatology (β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS (OR = 1.97, [1.26-3.07]) and the PRS for COVID-19 hospitalization (OR = 1.35, [1.01-1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity.
Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36893177</pmid><doi>10.1371/journal.pone.0282271</doi><tpages>e0282271</tpages><orcidid>https://orcid.org/0000-0001-7139-7007</orcidid><orcidid>https://orcid.org/0000-0002-0870-6628</orcidid><orcidid>https://orcid.org/0000-0001-9008-7004</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2785186783 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Allergic diseases Allergic reaction Allergy Asthma Asthma - diagnosis Asthma - genetics Asymptomatic Biology and Life Sciences Biomarkers Cardiovascular disease Coronary artery disease Coronary vessels Coronaviruses COVID-19 COVID-19 - genetics Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 Diagnosis Electronic health records Female Genetic factors Health risk assessment Heart diseases Hospitalization Humans Infections Laboratories Male Medical records Medicine and Health Sciences Nervous system Post traumatic stress disorder Respiratory diseases Risk Factors SARS-CoV-2 - genetics September 11 terrorist attacks-2001 Severe acute respiratory syndrome coronavirus 2 Variables Vein & artery diseases Viral diseases |
| title | Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T15%3A03%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polygenic%20risk%20scores%20for%20asthma%20and%20allergic%20disease%20associate%20with%20COVID-19%20severity%20in%209/11%20responders&rft.jtitle=PloS%20one&rft.au=Waszczuk,%20Monika%20A&rft.date=2023-03-09&rft.volume=18&rft.issue=3&rft.spage=e0282271&rft.epage=e0282271&rft.pages=e0282271-e0282271&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0282271&rft_dat=%3Cgale_plos_%3EA740267163%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2785186783&rft_id=info:pmid/36893177&rft_galeid=A740267163&rft_doaj_id=oai_doaj_org_article_04ebb6a53a5445968f8b47ac0c33707f&rfr_iscdi=true |