SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19

SARS-CoV-2-mediated COVID-19 may cause sudden cardiac death (SCD). Factors contributing to this increased risk of potentially fatal arrhythmias include thrombosis, exaggerated immune response, and treatment with QT-prolonging drugs. However, the intrinsic arrhythmic potential of direct SARS-CoV-2 in...

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Veröffentlicht in:	PloS one 2023-03, Vol.18 (3), p.e0282151-e0282151
Hauptverfasser:	Clemens, Daniel J, Ye, Dan, Zhou, Wei, Kim, C S John, Pease, David R, Navaratnarajah, Chanakha K, Barkhymer, Alison, Tester, David J, Nelson, Timothy J, Cattaneo, Roberto, Schneider, Jay W, Ackerman, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Action potential Action Potentials - physiology Analysis Antibodies Arrhythmia Arrhythmias, Cardiac - metabolism Biology and Life Sciences Calcium Calcium (intracellular) Calcium - metabolism Calcium imaging Calcium ions Calcium signalling Capacitance Cardiac arrest Cardiac arrhythmia Cardiomyocytes Cell fusion Cell morphology Cell size Cells COVID-19 COVID-19 - metabolism Cytology Dosage and administration Fibroblasts Fluorescence Furin Furin - metabolism Fusion protein Giant cells Handling Humans Immune response Immune system Immunofluorescence Immunosuppressive agents Induced Pluripotent Stem Cells Infections Long QT Syndrome - metabolism Medicine and health sciences Microscopy Mutagenesis Myocytes, Cardiac - metabolism Pandemics Plasmids Pluripotency Prevention Protease inhibitors Proteinase inhibitors Proteins Research and Analysis Methods Risk Risk factors SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Spike protein Statistical significance Stem cells Substrates Syncytia Thromboembolism Thrombosis Transfection Viral diseases
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