Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE-/- mice

Chronic low-grade inflammation is regarded to an important signature of atherosclerosis (AS). Macrophage (Mψ) and related polarization have been demonstrated to play a crucial role in the occurrence and development of AS inflammation. Butyrate, a bioactive molecule produced by the intestinal flora,...

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Veröffentlicht in:	PloS one 2023-03, Vol.18 (3), p.e0282685-e0282685
Hauptverfasser:	Ma, Huiyan, Yang, Libo, Liu, Yajuan, Yan, Ru, Wang, Rui, Zhang, Peng, Bai, Zhixia, Liu, Yuanyuan, Ren, Yi, Li, Yiwei, Jiang, Xin, Wang, Ting, Ma, Ping, Zhang, Qining, Li, Aifei, Guo, Mixue, Zhang, Xiaoxia, Jia, Shaobin, Wang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Aorta Apolipoprotein E Apolipoproteins E - genetics Apolipoproteins E - metabolism Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Bacteria Biology and Life Sciences Butyric Acid - metabolism Butyric Acid - pharmacology Cholesterol Correlation analysis Cytokines Diet Effectiveness Flora G protein-coupled receptors High density lipoprotein High fat diet Histone deacetylase Inflammation Interleukin Interleukin 10 Interleukin 6 Intestinal microflora Intestine Laboratory animals Lipopolysaccharides Lipoproteins Low density lipoprotein Macrophages Macrophages - metabolism Medical laboratories Medical research Medicine and Health Sciences Metabolic disorders Metabolism Mice Mice, Inbred C57BL Mice, Knockout, ApoE Microbiota MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Plasma Polarization Proteins Sodium Sodium butyrate Transcriptomes Triglycerides Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Zonula occludens-1 protein
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