Influence of location-dependent sex difference on PD-L1, MMR/MSI, and EGFR in colorectal carcinogenesis

The incidence and mortality rates of colorectal cancer (CRC) has been reported to be strongly associated to sex/gender difference. CRC shows sexual dimorphism, and sex hormones have been shown to affect the tumor immune microenvironment. This study aimed to investigate location-dependent sex differe...

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Veröffentlicht in:	PloS one 2023-02, Vol.18 (2), p.e0282017-e0282017
Hauptverfasser:	Choi, Jina, Kim, Nayoung, Nam, Ryoung Hee, Kim, Jin Won, Song, Chin-Hee, Na, Hee Young, Kang, Gyeong Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adenoma - genetics Adenoma - pathology Age Analysis B7-H1 Antigen Biology and Life Sciences Body mass index Carcinogenesis Carcinogenesis - genetics Carcinogens Care and treatment Colonoscopy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Diagnosis DNA Mismatch Repair Endoscopy Epidermal growth factor receptors ErbB Receptors - genetics Female Females Gastrointestinal cancer Gender Gender differences Growth factors Head & neck cancer Health aspects Health surveillance Hormones Humans Immunology Immunotherapy Lesions Lymphocytes Male Males Medicine and Health Sciences Microenvironments Microsatellite Instability Mismatch repair Mortality Multivariate analysis PD-L1 protein Polymerase chain reaction Polyps Proteins Sex Characteristics Sex differences Sex Factors Sex hormones Sexual dimorphism South Korea Statistics Tumor Microenvironment Tumors
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