Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence

The Arp2/3 complex is an actin nucleator with well-characterized activities in cell morphogenesis and movement, but its roles in nuclear processes are relatively understudied. We investigated how the Arp2/3 complex affects genomic integrity and cell cycle progression using mouse fibroblasts containi...

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Veröffentlicht in:	PLoS genetics 2023-01, Vol.19 (1), p.e1010045-e1010045
Hauptverfasser:	Haarer, Elena L, Theodore, Corey J, Guo, Shirley, Frier, Ryan B, Campellone, Kenneth G
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Actin Actin-Related Protein 2-3 Complex - genetics Actin-Related Protein 2-3 Complex - metabolism Actins - metabolism Anaphase Animals Antibodies Biology and Life Sciences Biosynthesis Biotechnology industry Cell adhesion & migration Cell cycle Cell research Cellular Senescence - genetics Chromatin Chromosomes Cytoskeleton Cytosol Deoxyribonucleic acid DNA DNA - metabolism DNA damage Ethical aspects Experiments Fibroblasts Genetic aspects Genomes Genomic instability Genomic Instability - genetics Genomics Insects Interferon regulatory factor 3 Medicine and Health Sciences Metaphase Mice Micronuclei Mitosis Mitosis - genetics Morphogenesis Motility Muscle proteins Nuclear membranes Phenotypes Physiological aspects Polymerization Proteins Research and Analysis Methods Senescence Stem cells Structure Tumor proteins Tumor suppressor genes
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