Magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients attending Hiwot Fana comprehensive specialized university hospital, Harar, Eastern Ethiopia
Dental caries is defined as a dynamic diet microbial disease of teeth, which results in localized dissolution and destruction of the mineralized tissues of the teeth. Dental caries develops when there is a susceptible tooth exposed to pathogenic bacteria in the presence of substrate. Under these con...
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| Veröffentlicht in: | PloS one 2023-02, Vol.18 (2), p.e0278829 |
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| description | Dental caries is defined as a dynamic diet microbial disease of teeth, which results in localized dissolution and destruction of the mineralized tissues of the teeth. Dental caries develops when there is a susceptible tooth exposed to pathogenic bacteria in the presence of substrate. Under these conditions, the bacteria metabolize substrate to form acid, which decalcifies teeth. Dental caries is among the top oral health problem in both developing and developed nations affecting around 20-50% of the population globally.
This study was conducted to assess the magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients visiting Hiwot Fana specialized university hospital dental clinic from April 23 to-June 23, 2021.
An institutional-based cross-sectional study was conducted among 290 study participants. Convenient sampling techniques were used to select the study participants. Data was entered into Epi-info version 7.2.4.0 and exported to Statistical Package for the Social Sciences version 20 for analysis. The result was explained by using summary measures of texts, tables, and graphs after analysis by using bivariate and multivariate logistic regression. Statistical significance was defined at a p-value of less than 0.05.
The overall magnitude of bacteria among dental caries patients was 68.3%. S mutans 74(37.4%) and Lactobacillus spp 58(29.3%) were the most predominant isolated bacteria. Lack of teeth brushing (AOR: 2.8, 95% CI:1.6, 4.6), the habit of chewing khat always (AOR:4.8, 95%CI:2.10,8.80), the habit of chewing khat sometimes (AOR: 3.8: 95% CI: 2.520,9.48) and consumption of soft drinks (AOR: 1.9, 95% CI:1.2,3.1) were significantly associated with bacterial dental caries. Almost, all bacterial isolates were susceptible to ceftriaxone and ciprofloxacin compared to Amoxicillin, Azithromycin, chloramphenicol, clindamycin, doxycycline, erythromycin, gentamycin, penicillin, tetracycline, vancomycin and tobramycin.
Teeth brushing habit, consumption of soft drink and a habit of chewing khat affects dental health and they are associated with bacterial dental caries. Harari regional health bureau better to focus by giving health education to the community about dental caries based on identified associated factors with dental caries. |
| doi_str_mv | 10.1371/journal.pone.0278829 |
| format | Article |
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This study was conducted to assess the magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients visiting Hiwot Fana specialized university hospital dental clinic from April 23 to-June 23, 2021.
An institutional-based cross-sectional study was conducted among 290 study participants. Convenient sampling techniques were used to select the study participants. Data was entered into Epi-info version 7.2.4.0 and exported to Statistical Package for the Social Sciences version 20 for analysis. The result was explained by using summary measures of texts, tables, and graphs after analysis by using bivariate and multivariate logistic regression. Statistical significance was defined at a p-value of less than 0.05.
The overall magnitude of bacteria among dental caries patients was 68.3%. S mutans 74(37.4%) and Lactobacillus spp 58(29.3%) were the most predominant isolated bacteria. Lack of teeth brushing (AOR: 2.8, 95% CI:1.6, 4.6), the habit of chewing khat always (AOR:4.8, 95%CI:2.10,8.80), the habit of chewing khat sometimes (AOR: 3.8: 95% CI: 2.520,9.48) and consumption of soft drinks (AOR: 1.9, 95% CI:1.2,3.1) were significantly associated with bacterial dental caries. Almost, all bacterial isolates were susceptible to ceftriaxone and ciprofloxacin compared to Amoxicillin, Azithromycin, chloramphenicol, clindamycin, doxycycline, erythromycin, gentamycin, penicillin, tetracycline, vancomycin and tobramycin.
Teeth brushing habit, consumption of soft drink and a habit of chewing khat affects dental health and they are associated with bacterial dental caries. Harari regional health bureau better to focus by giving health education to the community about dental caries based on identified associated factors with dental caries.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0278829</identifier><identifier>PMID: 36791121</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Amoxicillin ; Analysis ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Azithromycin ; Bacteria ; Beverages ; Biofilms ; Biology and Life Sciences ; Bivariate analysis ; Brushing ; Care and treatment ; Ceftriaxone ; Chewing ; Chloramphenicol ; Chloromycetin ; Ciprofloxacin ; Clindamycin ; Consumption ; Cotton ; Cross-Sectional Studies ; Data collection ; Dental caries ; Dental Caries - epidemiology ; Developed countries ; Diagnosis ; Diet ; Disease susceptibility ; Distribution ; Dosage and administration ; Doxycycline ; Erythromycin ; Ethiopia - epidemiology ; Gentamicin ; Gram-positive bacteria ; Health aspects ; Hospitals ; Hospitals, University ; Humans ; Laboratories ; Mastication ; Medicine and Health Sciences ; Microorganisms ; Oral hygiene ; Penicillin ; Population ; Population studies ; Questionnaires ; Sample size ; Sampling techniques ; Social Sciences ; Sociodemographics ; Soft drinks ; Stains & staining ; Statistical analysis ; Statistics ; Streptococcus infections ; Substrates ; Teeth ; Tobramycin ; Toothbrushing ; Vancomycin</subject><ispartof>PloS one, 2023-02, Vol.18 (2), p.e0278829</ispartof><rights>Copyright: © 2023 Maru et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Maru et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Maru et al 2023 Maru et al</rights><rights>2023 Maru et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c538t-1fc8bc1edfa008565680e89e9899832726ea767fe344d3cb6dd21611603f0b863</cites><orcidid>0000-0002-1626-5180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931146/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931146/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36791121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rahman, Ayesha Sabah</contributor><creatorcontrib>Maru, Mandie</creatorcontrib><creatorcontrib>Teklemariam, Zelalem</creatorcontrib><creatorcontrib>Admassu, Desalegn</creatorcontrib><title>Magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients attending Hiwot Fana comprehensive specialized university hospital, Harar, Eastern Ethiopia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Dental caries is defined as a dynamic diet microbial disease of teeth, which results in localized dissolution and destruction of the mineralized tissues of the teeth. Dental caries develops when there is a susceptible tooth exposed to pathogenic bacteria in the presence of substrate. Under these conditions, the bacteria metabolize substrate to form acid, which decalcifies teeth. Dental caries is among the top oral health problem in both developing and developed nations affecting around 20-50% of the population globally.
This study was conducted to assess the magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients visiting Hiwot Fana specialized university hospital dental clinic from April 23 to-June 23, 2021.
An institutional-based cross-sectional study was conducted among 290 study participants. Convenient sampling techniques were used to select the study participants. Data was entered into Epi-info version 7.2.4.0 and exported to Statistical Package for the Social Sciences version 20 for analysis. The result was explained by using summary measures of texts, tables, and graphs after analysis by using bivariate and multivariate logistic regression. Statistical significance was defined at a p-value of less than 0.05.
The overall magnitude of bacteria among dental caries patients was 68.3%. S mutans 74(37.4%) and Lactobacillus spp 58(29.3%) were the most predominant isolated bacteria. Lack of teeth brushing (AOR: 2.8, 95% CI:1.6, 4.6), the habit of chewing khat always (AOR:4.8, 95%CI:2.10,8.80), the habit of chewing khat sometimes (AOR: 3.8: 95% CI: 2.520,9.48) and consumption of soft drinks (AOR: 1.9, 95% CI:1.2,3.1) were significantly associated with bacterial dental caries. Almost, all bacterial isolates were susceptible to ceftriaxone and ciprofloxacin compared to Amoxicillin, Azithromycin, chloramphenicol, clindamycin, doxycycline, erythromycin, gentamycin, penicillin, tetracycline, vancomycin and tobramycin.
Teeth brushing habit, consumption of soft drink and a habit of chewing khat affects dental health and they are associated with bacterial dental caries. Harari regional health bureau better to focus by giving health education to the community about dental caries based on identified associated factors with dental caries.</description><subject>Adult</subject><subject>Amoxicillin</subject><subject>Analysis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Azithromycin</subject><subject>Bacteria</subject><subject>Beverages</subject><subject>Biofilms</subject><subject>Biology and Life Sciences</subject><subject>Bivariate analysis</subject><subject>Brushing</subject><subject>Care and treatment</subject><subject>Ceftriaxone</subject><subject>Chewing</subject><subject>Chloramphenicol</subject><subject>Chloromycetin</subject><subject>Ciprofloxacin</subject><subject>Clindamycin</subject><subject>Consumption</subject><subject>Cotton</subject><subject>Cross-Sectional Studies</subject><subject>Data collection</subject><subject>Dental caries</subject><subject>Dental Caries - epidemiology</subject><subject>Developed countries</subject><subject>Diagnosis</subject><subject>Diet</subject><subject>Disease susceptibility</subject><subject>Distribution</subject><subject>Dosage and administration</subject><subject>Doxycycline</subject><subject>Erythromycin</subject><subject>Ethiopia - epidemiology</subject><subject>Gentamicin</subject><subject>Gram-positive bacteria</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Mastication</subject><subject>Medicine and Health Sciences</subject><subject>Microorganisms</subject><subject>Oral hygiene</subject><subject>Penicillin</subject><subject>Population</subject><subject>Population studies</subject><subject>Questionnaires</subject><subject>Sample size</subject><subject>Sampling techniques</subject><subject>Social Sciences</subject><subject>Sociodemographics</subject><subject>Soft drinks</subject><subject>Stains & staining</subject><subject>Statistical analysis</subject><subject>Statistics</subject><subject>Streptococcus 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One</addtitle><date>2023-02-15</date><risdate>2023</risdate><volume>18</volume><issue>2</issue><spage>e0278829</spage><pages>e0278829-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Dental caries is defined as a dynamic diet microbial disease of teeth, which results in localized dissolution and destruction of the mineralized tissues of the teeth. Dental caries develops when there is a susceptible tooth exposed to pathogenic bacteria in the presence of substrate. Under these conditions, the bacteria metabolize substrate to form acid, which decalcifies teeth. Dental caries is among the top oral health problem in both developing and developed nations affecting around 20-50% of the population globally.
This study was conducted to assess the magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients visiting Hiwot Fana specialized university hospital dental clinic from April 23 to-June 23, 2021.
An institutional-based cross-sectional study was conducted among 290 study participants. Convenient sampling techniques were used to select the study participants. Data was entered into Epi-info version 7.2.4.0 and exported to Statistical Package for the Social Sciences version 20 for analysis. The result was explained by using summary measures of texts, tables, and graphs after analysis by using bivariate and multivariate logistic regression. Statistical significance was defined at a p-value of less than 0.05.
The overall magnitude of bacteria among dental caries patients was 68.3%. S mutans 74(37.4%) and Lactobacillus spp 58(29.3%) were the most predominant isolated bacteria. Lack of teeth brushing (AOR: 2.8, 95% CI:1.6, 4.6), the habit of chewing khat always (AOR:4.8, 95%CI:2.10,8.80), the habit of chewing khat sometimes (AOR: 3.8: 95% CI: 2.520,9.48) and consumption of soft drinks (AOR: 1.9, 95% CI:1.2,3.1) were significantly associated with bacterial dental caries. Almost, all bacterial isolates were susceptible to ceftriaxone and ciprofloxacin compared to Amoxicillin, Azithromycin, chloramphenicol, clindamycin, doxycycline, erythromycin, gentamycin, penicillin, tetracycline, vancomycin and tobramycin.
Teeth brushing habit, consumption of soft drink and a habit of chewing khat affects dental health and they are associated with bacterial dental caries. Harari regional health bureau better to focus by giving health education to the community about dental caries based on identified associated factors with dental caries.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36791121</pmid><doi>10.1371/journal.pone.0278829</doi><tpages>e0278829</tpages><orcidid>https://orcid.org/0000-0002-1626-5180</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-02, Vol.18 (2), p.e0278829 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2776985219 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Amoxicillin Analysis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antiinfectives and antibacterials Antimicrobial agents Azithromycin Bacteria Beverages Biofilms Biology and Life Sciences Bivariate analysis Brushing Care and treatment Ceftriaxone Chewing Chloramphenicol Chloromycetin Ciprofloxacin Clindamycin Consumption Cotton Cross-Sectional Studies Data collection Dental caries Dental Caries - epidemiology Developed countries Diagnosis Diet Disease susceptibility Distribution Dosage and administration Doxycycline Erythromycin Ethiopia - epidemiology Gentamicin Gram-positive bacteria Health aspects Hospitals Hospitals, University Humans Laboratories Mastication Medicine and Health Sciences Microorganisms Oral hygiene Penicillin Population Population studies Questionnaires Sample size Sampling techniques Social Sciences Sociodemographics Soft drinks Stains & staining Statistical analysis Statistics Streptococcus infections Substrates Teeth Tobramycin Toothbrushing Vancomycin |
| title | Magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients attending Hiwot Fana comprehensive specialized university hospital, Harar, Eastern Ethiopia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T10%3A46%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnitude,%20associated%20factors,%20and%20antimicrobial%20susceptibility%20pattern%20of%20bacterial%20isolates%20among%20adult%20dental%20caries%20patients%20attending%20Hiwot%20Fana%20comprehensive%20specialized%20university%20hospital,%20Harar,%20Eastern%20Ethiopia&rft.jtitle=PloS%20one&rft.au=Maru,%20Mandie&rft.date=2023-02-15&rft.volume=18&rft.issue=2&rft.spage=e0278829&rft.pages=e0278829-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0278829&rft_dat=%3Cgale_plos_%3EA737340322%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2776985219&rft_id=info:pmid/36791121&rft_galeid=A737340322&rft_doaj_id=oai_doaj_org_article_5a9cd062626b4e4bbe8d99776566b6ea&rfr_iscdi=true |