Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study
Evidence on the association between mental health disorders and cancer risk is inconclusive, despite well-established associations between mental health disorders and lifestyle factors such as smoking. This study examines the relationships between depression, anxiety and cancer risk, and the potenti...
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| description | Evidence on the association between mental health disorders and cancer risk is inconclusive, despite well-established associations between mental health disorders and lifestyle factors such as smoking. This study examines the relationships between depression, anxiety and cancer risk, and the potential mediating effects of lifestyle factors.
A study of 34,571 participants aged 40-69 years in the CARTaGENE cohort was conducted. Depression was defined by questionnaire (PHQ-9), antidepressant use, and a composite of questionnaire, antidepressant use, or lifetime self-reported physician diagnosis. Anxiety was defined by questionnaire (GAD-7). Co-morbid depression and anxiety was also assessed. Cox regression models were used to investigate associations between mental health and risk of prostate, lung, and all cancers combined. Mediating effects of lifestyle factors were assessed using Baron and Kenny mediation criteria.
There were positive associations between mental health disorders, all cancers and lung cancer risk, however with the exception of anxiety and lung cancer in women (Hazard Ratio [HR] = 1.67, 95% CI: 1.01-2.76), associations were attenuated with adjustment for sociodemographics, health status and lifestyle factors. In the mediation analysis, smoking accounted for 27%, 18%, and 26%, of the total effect between depression (PHQ-9), anxiety, and co-morbidity and lung cancer, respectively in women. In men, smoking accounted for 17% of the total effect between depression (PHQ-9, antidepressant, or lifetime self-report of physician diagnosis) and all cancers.
Positive associations were observed between mental health disorders, all cancer and lung cancer risk, however most relationships were attenuated with adjustment for lifestyle factors. Smoking status mediated a significant proportion of the relationships between mental health disorders and cancer risk. |
| doi_str_mv | 10.1371/journal.pone.0281588 |
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A study of 34,571 participants aged 40-69 years in the CARTaGENE cohort was conducted. Depression was defined by questionnaire (PHQ-9), antidepressant use, and a composite of questionnaire, antidepressant use, or lifetime self-reported physician diagnosis. Anxiety was defined by questionnaire (GAD-7). Co-morbid depression and anxiety was also assessed. Cox regression models were used to investigate associations between mental health and risk of prostate, lung, and all cancers combined. Mediating effects of lifestyle factors were assessed using Baron and Kenny mediation criteria.
There were positive associations between mental health disorders, all cancers and lung cancer risk, however with the exception of anxiety and lung cancer in women (Hazard Ratio [HR] = 1.67, 95% CI: 1.01-2.76), associations were attenuated with adjustment for sociodemographics, health status and lifestyle factors. In the mediation analysis, smoking accounted for 27%, 18%, and 26%, of the total effect between depression (PHQ-9), anxiety, and co-morbidity and lung cancer, respectively in women. In men, smoking accounted for 17% of the total effect between depression (PHQ-9, antidepressant, or lifetime self-report of physician diagnosis) and all cancers.
Positive associations were observed between mental health disorders, all cancer and lung cancer risk, however most relationships were attenuated with adjustment for lifestyle factors. Smoking status mediated a significant proportion of the relationships between mental health disorders and cancer risk.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0281588</identifier><identifier>PMID: 36787319</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol ; Antidepressants ; Antidepressive Agents ; Anxiety ; Anxiety - complications ; Anxiety - epidemiology ; Anxiety - psychology ; Breast cancer ; Cancer ; Cancer patients ; Care and treatment ; Chronic illnesses ; Cohort analysis ; Cohort Studies ; Colorectal cancer ; Depression - complications ; Depression - epidemiology ; Depression - psychology ; Diabetes ; Diagnosis ; Disorders ; Dosage and administration ; Ethnicity ; Family medical history ; Female ; Health aspects ; Health care ; Health risks ; Humans ; Life Style ; Lifestyles ; Lung cancer ; Lung diseases ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Male ; Mediation ; Medical diagnosis ; Medical societies ; Medicine and Health Sciences ; Mental depression ; Mental disorders ; Mental Health ; Mental illness ; Morbidity ; Oncology, Experimental ; Physicians ; Primary care ; Prostate cancer ; Questionnaires ; Regression analysis ; Regression models ; Risk ; Risk Factors ; Self report ; Sleep ; Smoking ; Sociodemographics ; Surveys</subject><ispartof>PloS one, 2023-02, Vol.18 (2), p.e0281588</ispartof><rights>Copyright: © 2023 Gilham et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Gilham et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Gilham et al 2023 Gilham et al</rights><rights>2023 Gilham et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c5880ccee8547f134ce48bcdd67136ffe47c4eb0fcf3c54ffe77718aef1f65973</citedby><cites>FETCH-LOGICAL-c692t-c5880ccee8547f134ce48bcdd67136ffe47c4eb0fcf3c54ffe77718aef1f65973</cites><orcidid>0000-0002-2510-3570 ; 0000-0003-4383-5641</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928103/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928103/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36787319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chang, Chin-Kuo</contributor><creatorcontrib>Gilham, Kaitlyn</creatorcontrib><creatorcontrib>Gadermann, Anne</creatorcontrib><creatorcontrib>Dummer, Trevor</creatorcontrib><creatorcontrib>Murphy, Rachel A</creatorcontrib><title>Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Evidence on the association between mental health disorders and cancer risk is inconclusive, despite well-established associations between mental health disorders and lifestyle factors such as smoking. This study examines the relationships between depression, anxiety and cancer risk, and the potential mediating effects of lifestyle factors.
A study of 34,571 participants aged 40-69 years in the CARTaGENE cohort was conducted. Depression was defined by questionnaire (PHQ-9), antidepressant use, and a composite of questionnaire, antidepressant use, or lifetime self-reported physician diagnosis. Anxiety was defined by questionnaire (GAD-7). Co-morbid depression and anxiety was also assessed. Cox regression models were used to investigate associations between mental health and risk of prostate, lung, and all cancers combined. Mediating effects of lifestyle factors were assessed using Baron and Kenny mediation criteria.
There were positive associations between mental health disorders, all cancers and lung cancer risk, however with the exception of anxiety and lung cancer in women (Hazard Ratio [HR] = 1.67, 95% CI: 1.01-2.76), associations were attenuated with adjustment for sociodemographics, health status and lifestyle factors. In the mediation analysis, smoking accounted for 27%, 18%, and 26%, of the total effect between depression (PHQ-9), anxiety, and co-morbidity and lung cancer, respectively in women. In men, smoking accounted for 17% of the total effect between depression (PHQ-9, antidepressant, or lifetime self-report of physician diagnosis) and all cancers.
Positive associations were observed between mental health disorders, all cancer and lung cancer risk, however most relationships were attenuated with adjustment for lifestyle factors. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilham, Kaitlyn</au><au>Gadermann, Anne</au><au>Dummer, Trevor</au><au>Murphy, Rachel A</au><au>Chang, Chin-Kuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-02-14</date><risdate>2023</risdate><volume>18</volume><issue>2</issue><spage>e0281588</spage><pages>e0281588-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Evidence on the association between mental health disorders and cancer risk is inconclusive, despite well-established associations between mental health disorders and lifestyle factors such as smoking. This study examines the relationships between depression, anxiety and cancer risk, and the potential mediating effects of lifestyle factors.
A study of 34,571 participants aged 40-69 years in the CARTaGENE cohort was conducted. Depression was defined by questionnaire (PHQ-9), antidepressant use, and a composite of questionnaire, antidepressant use, or lifetime self-reported physician diagnosis. Anxiety was defined by questionnaire (GAD-7). Co-morbid depression and anxiety was also assessed. Cox regression models were used to investigate associations between mental health and risk of prostate, lung, and all cancers combined. Mediating effects of lifestyle factors were assessed using Baron and Kenny mediation criteria.
There were positive associations between mental health disorders, all cancers and lung cancer risk, however with the exception of anxiety and lung cancer in women (Hazard Ratio [HR] = 1.67, 95% CI: 1.01-2.76), associations were attenuated with adjustment for sociodemographics, health status and lifestyle factors. In the mediation analysis, smoking accounted for 27%, 18%, and 26%, of the total effect between depression (PHQ-9), anxiety, and co-morbidity and lung cancer, respectively in women. In men, smoking accounted for 17% of the total effect between depression (PHQ-9, antidepressant, or lifetime self-report of physician diagnosis) and all cancers.
Positive associations were observed between mental health disorders, all cancer and lung cancer risk, however most relationships were attenuated with adjustment for lifestyle factors. Smoking status mediated a significant proportion of the relationships between mental health disorders and cancer risk.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36787319</pmid><doi>10.1371/journal.pone.0281588</doi><tpages>e0281588</tpages><orcidid>https://orcid.org/0000-0002-2510-3570</orcidid><orcidid>https://orcid.org/0000-0003-4383-5641</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alcohol Antidepressants Antidepressive Agents Anxiety Anxiety - complications Anxiety - epidemiology Anxiety - psychology Breast cancer Cancer Cancer patients Care and treatment Chronic illnesses Cohort analysis Cohort Studies Colorectal cancer Depression - complications Depression - epidemiology Depression - psychology Diabetes Diagnosis Disorders Dosage and administration Ethnicity Family medical history Female Health aspects Health care Health risks Humans Life Style Lifestyles Lung cancer Lung diseases Lung Neoplasms - epidemiology Lung Neoplasms - etiology Male Mediation Medical diagnosis Medical societies Medicine and Health Sciences Mental depression Mental disorders Mental Health Mental illness Morbidity Oncology, Experimental Physicians Primary care Prostate cancer Questionnaires Regression analysis Regression models Risk Risk Factors Self report Sleep Smoking Sociodemographics Surveys |
| title | Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T10%3A35%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mental%20health,%20cancer%20risk,%20and%20the%20mediating%20role%20of%20lifestyle%20factors%20in%20the%20CARTaGENE%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Gilham,%20Kaitlyn&rft.date=2023-02-14&rft.volume=18&rft.issue=2&rft.spage=e0281588&rft.pages=e0281588-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0281588&rft_dat=%3Cgale_plos_%3EA737156087%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2776415997&rft_id=info:pmid/36787319&rft_galeid=A737156087&rft_doaj_id=oai_doaj_org_article_efa9a3816e79460dbe1667b7b9750233&rfr_iscdi=true |