Visualizing increased uptake of [18F]FDG and [18F]FTHA in kidneys from obese high-fat diet fed C57BL/6J mice using PET/CT ex vivo

It is known that high-fat diet (HFD) and/or diabetes may influence substrate preferences and energy demands in the heart preceding diabetic cardiomyopathy. They may also induce structural glomerular changes causing diabetic nephropathy. PET/CT has been utilized to examine uptake of energy substrates...

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Veröffentlicht in:	PloS one 2023-02, Vol.18 (2), p.e0281705-e0281705
Hauptverfasser:	Nyrén, Rakel, Scherman, Henrik, Axelsson, Jan, Chang, Chuchun L, Olivecrona, Gunilla, Ericsson, Madelene
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin Animals Biology and Life Sciences Body fat Cardiomyopathy Care and treatment Complications and side effects Computed tomography Dextrose Diabetes Diabetes mellitus Diabetic Nephropathies Diabetic nephropathy Diet Diet, High-Fat Disease Energy Energy resources Ethanol Experiments Fatty acids Fatty Acids - metabolism Fluorine isotopes Fluorodeoxyglucose F18 Glucose Glucose - metabolism Health aspects Heart failure High fat diet In vivo methods and tests Insulin Insulin resistance Kidney - diagnostic imaging Kidney - metabolism Kidneys Lipids Lipoprotein lipase Lipoproteins Medicine and Health Sciences Metabolic disorders Metabolism Mice Mice, Inbred C57BL Nephropathy Obesity Obesity - diagnostic imaging Patient outcomes PET imaging Physical Sciences Positron emission Positron Emission Tomography Computed Tomography Preferences Research and Analysis Methods Substrate preferences Substrates Tomography Triglycerides
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