Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways

Accumulating data demonstrates that new adult cardiomyocytes (CMs) are generated throughout life from pre-existing CMs, although the absolute magnitude of CM self-renewal is very low. Modifying epigenetic histone modifications or activating the Hippo-Yap pathway have been shown to promote adult CM c...

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Veröffentlicht in:	PloS one 2023-02, Vol.18 (2), p.e0281610
Hauptverfasser:	Zhang, Zhenhe, Freeman, Miles, Zhang, Yiqiang, El-Nachef, Danny, Davenport, George, Williams, Allison, MacLellan, W Robb
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Analysis Animals Apoptosis Biology and Life Sciences Cardiac function Cardiac muscle Cardiomyocytes Cardiovascular diseases Cell culture Cell cycle Cell Cycle - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell number Cell self-renewal Cycles Demethylation Epigenetic inheritance Epigenetics Ethylenediaminetetraacetic acid Gene expression Genes Genetic aspects Genetic engineering Genetic transcription Glucose Health aspects Heart Heart cells Heart diseases Heart failure Hippo Signaling Pathway Histones Histones - metabolism Infections Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Kinases Laboratory animals Lysine Medicine and Health Sciences Methods Methylation Mice Mice, Transgenic MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Myc protein Myocytes Myocytes, Cardiac - metabolism Neonates Ostomy Prevention Rats Research and Analysis Methods Risk factors S phase Signal transduction Signaling Transgenic mice Ventricle Yes-associated protein
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