The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors
CPT1A is a rate-limiting enzyme in fatty acid oxidation and is upregulated in high-risk breast cancer. Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena...
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| Veröffentlicht in: | PloS one 2023-02, Vol.18 (2), p.e0281252-e0281252 |
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| description | CPT1A is a rate-limiting enzyme in fatty acid oxidation and is upregulated in high-risk breast cancer. Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena Functional Genomics Explorer, to explore CPT1A's effect on breast cancer patients' survival probability. Using [18F]-fluorothymidine positron emission tomography-computed tomography images from The Cancer Imaging Archive, we segmented these analyses by obesity and menopausal status. In 1214 patients, higher CPT1A expression is associated with lower breast cancer survivability. We confirmed a previously observed protective relationship between obesity and breast cancer in pre-menopausal patients and supported this data using two-sided Pearson correlations. Taken together, these analyses using open-access databases bolster the potential role of CPT1A-dependent fatty acid metabolism as a pathogenic factor in breast cancer. |
| doi_str_mv | 10.1371/journal.pone.0281252 |
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Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena Functional Genomics Explorer, to explore CPT1A's effect on breast cancer patients' survival probability. Using [18F]-fluorothymidine positron emission tomography-computed tomography images from The Cancer Imaging Archive, we segmented these analyses by obesity and menopausal status. In 1214 patients, higher CPT1A expression is associated with lower breast cancer survivability. We confirmed a previously observed protective relationship between obesity and breast cancer in pre-menopausal patients and supported this data using two-sided Pearson correlations. Taken together, these analyses using open-access databases bolster the potential role of CPT1A-dependent fatty acid metabolism as a pathogenic factor in breast cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0281252</identifier><identifier>PMID: 36735704</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Body mass index ; Body measurements ; Breast cancer ; Breast Neoplasms - pathology ; Cancer patients ; Carnitine ; Carnitine O-Palmitoyltransferase - genetics ; Carnitine O-Palmitoyltransferase - metabolism ; Carnitine palmitoyltransferase ; Cell cycle ; Computed tomography ; Computer and Information Sciences ; CT imaging ; Datasets ; Dependent variables ; Enzymes ; Fatty acids ; Fatty Acids - metabolism ; Female ; Gene expression ; Gene sequencing ; Genetic aspects ; Genomics ; Health aspects ; Health risks ; Humans ; Kidney cancer ; Medical prognosis ; Medicine and Health Sciences ; Menopause ; Metabolism ; Mortality ; Mutation ; Obesity ; Oxidation ; Palmitoyltransferase ; PET imaging ; Physiological aspects ; Positron emission ; Positron emission tomography ; Premenopause ; Prognosis ; Research and Analysis Methods ; RNA sequencing ; Survivability ; Tomography ; Tumors</subject><ispartof>PloS one, 2023-02, Vol.18 (2), p.e0281252-e0281252</ispartof><rights>Copyright: © 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Liu et al 2023 Liu et al</rights><rights>2023 Liu et al. 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Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena Functional Genomics Explorer, to explore CPT1A's effect on breast cancer patients' survival probability. Using [18F]-fluorothymidine positron emission tomography-computed tomography images from The Cancer Imaging Archive, we segmented these analyses by obesity and menopausal status. In 1214 patients, higher CPT1A expression is associated with lower breast cancer survivability. We confirmed a previously observed protective relationship between obesity and breast cancer in pre-menopausal patients and supported this data using two-sided Pearson correlations. Taken together, these analyses using open-access databases bolster the potential role of CPT1A-dependent fatty acid metabolism as a pathogenic factor in breast cancer.</description><subject>Biology and Life Sciences</subject><subject>Body mass index</subject><subject>Body measurements</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer patients</subject><subject>Carnitine</subject><subject>Carnitine O-Palmitoyltransferase - genetics</subject><subject>Carnitine O-Palmitoyltransferase - metabolism</subject><subject>Carnitine palmitoyltransferase</subject><subject>Cell cycle</subject><subject>Computed tomography</subject><subject>Computer and Information Sciences</subject><subject>CT imaging</subject><subject>Datasets</subject><subject>Dependent variables</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Fatty Acids - metabolism</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene 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impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors</title><author>Liu, Ryan ; Ospanova, Shyryn ; Perry, Rachel J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-fac427b2adf0b813ae90301090a5cbf888946a411d5c3c77e66548d91d9032073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biology and Life Sciences</topic><topic>Body mass index</topic><topic>Body measurements</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer patients</topic><topic>Carnitine</topic><topic>Carnitine O-Palmitoyltransferase - genetics</topic><topic>Carnitine O-Palmitoyltransferase - metabolism</topic><topic>Carnitine palmitoyltransferase</topic><topic>Cell cycle</topic><topic>Computed tomography</topic><topic>Computer and Information Sciences</topic><topic>CT 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ryan</au><au>Ospanova, Shyryn</au><au>Perry, Rachel J</au><au>Agarwal, Divyansh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-02-03</date><risdate>2023</risdate><volume>18</volume><issue>2</issue><spage>e0281252</spage><epage>e0281252</epage><pages>e0281252-e0281252</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>CPT1A is a rate-limiting enzyme in fatty acid oxidation and is upregulated in high-risk breast cancer. Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena Functional Genomics Explorer, to explore CPT1A's effect on breast cancer patients' survival probability. Using [18F]-fluorothymidine positron emission tomography-computed tomography images from The Cancer Imaging Archive, we segmented these analyses by obesity and menopausal status. In 1214 patients, higher CPT1A expression is associated with lower breast cancer survivability. We confirmed a previously observed protective relationship between obesity and breast cancer in pre-menopausal patients and supported this data using two-sided Pearson correlations. Taken together, these analyses using open-access databases bolster the potential role of CPT1A-dependent fatty acid metabolism as a pathogenic factor in breast cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36735704</pmid><doi>10.1371/journal.pone.0281252</doi><tpages>e0281252</tpages><orcidid>https://orcid.org/0000-0003-0748-8064</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Body mass index Body measurements Breast cancer Breast Neoplasms - pathology Cancer patients Carnitine Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Carnitine palmitoyltransferase Cell cycle Computed tomography Computer and Information Sciences CT imaging Datasets Dependent variables Enzymes Fatty acids Fatty Acids - metabolism Female Gene expression Gene sequencing Genetic aspects Genomics Health aspects Health risks Humans Kidney cancer Medical prognosis Medicine and Health Sciences Menopause Metabolism Mortality Mutation Obesity Oxidation Palmitoyltransferase PET imaging Physiological aspects Positron emission Positron emission tomography Premenopause Prognosis Research and Analysis Methods RNA sequencing Survivability Tomography Tumors |
| title | The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors |
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