Levofloxacin induces differential effects in the transcriptome between the gut, peripheral and axial joints in the Spondyloarthritis DBA/1 mice: Improvement of intestinal dysbiosis and the overall inflammatory process

To analyze the effect of levofloxacin-induced intestinal microbiota modifications on intestinal, joint, and systemic inflammation in the DBA/1 mice with spontaneous arthritis. The study included two groups of mice, one of which received levofloxacin. The composition and structure of the microbiota w...

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Veröffentlicht in:	PloS one 2023-02, Vol.18 (2), p.e0281265-e0281265
Hauptverfasser:	González-Chávez, Susana Aideé, Salas-Leiva, Joan S, Salas-Leiva, Dayana E, López-Loeza, Salma Marcela, Sausameda-García, Jasanai, Orrantia-Borunda, Erasmo, Burgos-Vargas, Rubén, Alvarado-Jáquez, Maria Fernanda, Torres-Quintana, Mayra, Cuevas-Martínez, Rubén, Chaparro-Barrera, Eduardo, Marín-Terrazas, Carlos, Espino-Solís, Gerardo Pável, Romero-López, José Pablo, Bernal-Alferes, Brian de Jesús, Pacheco-Tena, César
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Arthritis Bacteria Biology and Life Sciences Care and treatment Cartilage Chemokines Complications and side effects Computer and Information Sciences Deoxyribonucleic acid Diagnosis Discriminant analysis DNA DNA chips DNA microarrays Dysbacteriosis Dysbiosis - microbiology Flow cytometry Health aspects Hyperplasia Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Inflammatory diseases Interleukin 17 Intestinal microflora Intestine Joint diseases Joints (anatomy) Laboratory animals Levofloxacin Levofloxacin - pharmacology Medicine and Health Sciences Metabolic pathways Metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Microbiota Microbiota (Symbiotic organisms) Pathogenesis Patient outcomes Research and Analysis Methods Rheumatic diseases RNA, Ribosomal, 16S - genetics rRNA 16S Spondylarthritis Taxonomy Transcriptome Transcriptomes Transcriptomics Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α
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