The Genomic landscape of short tandem repeats across multiple ancestries

Short Tandem Repeats (STRs) have been found to play a role in a myriad of complex traits and genetic diseases. We examined the variability in the lengths of over 850,000 STR loci in 996 children with suspected genetic disorders and 1,178 parents across six separate ancestral groups: Africans, Europe...

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Veröffentlicht in:	PloS one 2023-01, Vol.18 (1), p.e0279430-e0279430
Hauptverfasser:	Vijayaraghavan, Prashanth, Batalov, Sergey, Ding, Yan, Sanford, Erica, Kingsmore, Stephen F, Dimmock, David, Hobbs, Charlotte, Bainbridge, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Americans Atrophy Biology and Life Sciences Comparative analysis Cornea Disease Exons Genes Genetic disorders Genomics High-Throughput Nucleotide Sequencing Humans Intellectual disabilities Medical research Medicine and Health Sciences Medicine, Experimental Microsatellite Repeats - genetics Mutation Pacific Islander people Parents Pathogenicity Pathogens People and Places Physical Sciences Population Risk factors Short tandem repeats Statistics
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