Estimated pulse wave velocity as a measure of vascular aging
Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examines the construct validity of a me...
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| creator | Heffernan, Kevin S Stoner, Lee London, Andrew S Augustine, Jacqueline A Lefferts, Wesley K |
| description | Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examines the construct validity of a measure of PWV estimated from age and blood pressure (ePWV). The specific aims of the study are to: 1) explore the strength of association between ePWV, cfPWV, and other established measures of vascular aging; 2) examine the sensitivity and specificity of elevated ePWV (≥10m/s) in relation to elevated cfPWV (≥10m/s).
We measured cfPWV in two-hundred and fifty-two adults (mean age 57±12 years, 48% female) and calculated each participant's ePWV from their age and brachial blood pressure. Additional measures of vascular aging included: carotid intima-media thickness (cIMT); carotid stiffness measured as elastic modulus (cEp); and carotid augmentation index (cAIx).
The correlations between cfPWV and measures of vascular aging were: cEp (r = 0.36), cIMT (r = 0.49), and cAIx (r = 0.04). The correlations between ePWV and measures of vascular aging were: cEp (r = 0.45), cIMT (r = 0.60), and cAIx (r = 0.24). The correlation between ePWV and cfPWV was (r = 0.67). The sensitivity and specificity of elevated ePWV (≥ 10 m/s) for concomitantly identifying high cfPWV (≥ 10 m/s) were 85.4% and 73.0% respectively.
ePWV is associated with established measures of vascular aging, such as carotid thickness, carotid stiffness and carotid augmentation index. ePWV may be a useful tool to help promote research on vascular aging. |
| doi_str_mv | 10.1371/journal.pone.0280896 |
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We measured cfPWV in two-hundred and fifty-two adults (mean age 57±12 years, 48% female) and calculated each participant's ePWV from their age and brachial blood pressure. Additional measures of vascular aging included: carotid intima-media thickness (cIMT); carotid stiffness measured as elastic modulus (cEp); and carotid augmentation index (cAIx).
The correlations between cfPWV and measures of vascular aging were: cEp (r = 0.36), cIMT (r = 0.49), and cAIx (r = 0.04). The correlations between ePWV and measures of vascular aging were: cEp (r = 0.45), cIMT (r = 0.60), and cAIx (r = 0.24). The correlation between ePWV and cfPWV was (r = 0.67). The sensitivity and specificity of elevated ePWV (≥ 10 m/s) for concomitantly identifying high cfPWV (≥ 10 m/s) were 85.4% and 73.0% respectively.
ePWV is associated with established measures of vascular aging, such as carotid thickness, carotid stiffness and carotid augmentation index. ePWV may be a useful tool to help promote research on vascular aging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0280896</identifier><identifier>PMID: 36701358</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Aging ; Aging - physiology ; Aorta ; Augmentation ; Biology and Life Sciences ; Blood circulation disorders ; Blood Pressure ; Body mass index ; Caffeine ; Cardiovascular disease ; Carotid arteries ; Carotid Intima-Media Thickness ; Correlation ; Diabetes ; Diagnosis ; Electrocardiography ; Exercise ; Female ; Health aspects ; Humans ; Hypertension ; Male ; Measurement ; Mechanical properties ; Medicine and Health Sciences ; Metabolic disorders ; Middle Aged ; Modulus of elasticity ; Mortality ; Physical Sciences ; Physiology ; Pulse ; Pulse Wave Analysis ; Risk Factors ; Sensitivity ; Stiffness ; Thickness ; Ultrasonic imaging ; Validation studies ; Validity ; Vascular Stiffness - physiology ; Veins & arteries ; Velocity ; Wave velocity</subject><ispartof>PloS one, 2023-01, Vol.18 (1), p.e0280896-e0280896</ispartof><rights>Copyright: © 2023 Heffernan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Heffernan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Heffernan et al 2023 Heffernan et al</rights><rights>2023 Heffernan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d8c88672575940de4eb9b6fbecdc17aefa12c37afac4f5b42c163bca92e8a4443</citedby><cites>FETCH-LOGICAL-c692t-d8c88672575940de4eb9b6fbecdc17aefa12c37afac4f5b42c163bca92e8a4443</cites><orcidid>0000-0001-6339-4279 ; 0000-0002-0682-2270 ; 0000-0002-3499-1477 ; 0000-0001-5957-391X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879446/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879446/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36701358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pucci, Giacomo</contributor><creatorcontrib>Heffernan, Kevin S</creatorcontrib><creatorcontrib>Stoner, Lee</creatorcontrib><creatorcontrib>London, Andrew S</creatorcontrib><creatorcontrib>Augustine, Jacqueline A</creatorcontrib><creatorcontrib>Lefferts, Wesley K</creatorcontrib><title>Estimated pulse wave velocity as a measure of vascular aging</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examines the construct validity of a measure of PWV estimated from age and blood pressure (ePWV). The specific aims of the study are to: 1) explore the strength of association between ePWV, cfPWV, and other established measures of vascular aging; 2) examine the sensitivity and specificity of elevated ePWV (≥10m/s) in relation to elevated cfPWV (≥10m/s).
We measured cfPWV in two-hundred and fifty-two adults (mean age 57±12 years, 48% female) and calculated each participant's ePWV from their age and brachial blood pressure. Additional measures of vascular aging included: carotid intima-media thickness (cIMT); carotid stiffness measured as elastic modulus (cEp); and carotid augmentation index (cAIx).
The correlations between cfPWV and measures of vascular aging were: cEp (r = 0.36), cIMT (r = 0.49), and cAIx (r = 0.04). The correlations between ePWV and measures of vascular aging were: cEp (r = 0.45), cIMT (r = 0.60), and cAIx (r = 0.24). The correlation between ePWV and cfPWV was (r = 0.67). The sensitivity and specificity of elevated ePWV (≥ 10 m/s) for concomitantly identifying high cfPWV (≥ 10 m/s) were 85.4% and 73.0% respectively.
ePWV is associated with established measures of vascular aging, such as carotid thickness, carotid stiffness and carotid augmentation index. ePWV may be a useful tool to help promote research on vascular aging.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Aorta</subject><subject>Augmentation</subject><subject>Biology and Life Sciences</subject><subject>Blood circulation disorders</subject><subject>Blood Pressure</subject><subject>Body mass index</subject><subject>Caffeine</subject><subject>Cardiovascular disease</subject><subject>Carotid arteries</subject><subject>Carotid Intima-Media Thickness</subject><subject>Correlation</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Electrocardiography</subject><subject>Exercise</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Measurement</subject><subject>Mechanical properties</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>Modulus of elasticity</subject><subject>Mortality</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Pulse</subject><subject>Pulse Wave Analysis</subject><subject>Risk Factors</subject><subject>Sensitivity</subject><subject>Stiffness</subject><subject>Thickness</subject><subject>Ultrasonic imaging</subject><subject>Validation studies</subject><subject>Validity</subject><subject>Vascular Stiffness - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heffernan, Kevin S</au><au>Stoner, Lee</au><au>London, Andrew S</au><au>Augustine, Jacqueline A</au><au>Lefferts, Wesley K</au><au>Pucci, Giacomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimated pulse wave velocity as a measure of vascular aging</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-01-26</date><risdate>2023</risdate><volume>18</volume><issue>1</issue><spage>e0280896</spage><epage>e0280896</epage><pages>e0280896-e0280896</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Carotid-femoral pulse wave velocity (cfPWV), the referent measure of aortic stiffness, is an established measure of vascular aging. In studies where cfPWV cannot be measured, alternative methods are needed to help promote research on vascular aging. This study examines the construct validity of a measure of PWV estimated from age and blood pressure (ePWV). The specific aims of the study are to: 1) explore the strength of association between ePWV, cfPWV, and other established measures of vascular aging; 2) examine the sensitivity and specificity of elevated ePWV (≥10m/s) in relation to elevated cfPWV (≥10m/s).
We measured cfPWV in two-hundred and fifty-two adults (mean age 57±12 years, 48% female) and calculated each participant's ePWV from their age and brachial blood pressure. Additional measures of vascular aging included: carotid intima-media thickness (cIMT); carotid stiffness measured as elastic modulus (cEp); and carotid augmentation index (cAIx).
The correlations between cfPWV and measures of vascular aging were: cEp (r = 0.36), cIMT (r = 0.49), and cAIx (r = 0.04). The correlations between ePWV and measures of vascular aging were: cEp (r = 0.45), cIMT (r = 0.60), and cAIx (r = 0.24). The correlation between ePWV and cfPWV was (r = 0.67). The sensitivity and specificity of elevated ePWV (≥ 10 m/s) for concomitantly identifying high cfPWV (≥ 10 m/s) were 85.4% and 73.0% respectively.
ePWV is associated with established measures of vascular aging, such as carotid thickness, carotid stiffness and carotid augmentation index. ePWV may be a useful tool to help promote research on vascular aging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36701358</pmid><doi>10.1371/journal.pone.0280896</doi><tpages>e0280896</tpages><orcidid>https://orcid.org/0000-0001-6339-4279</orcidid><orcidid>https://orcid.org/0000-0002-0682-2270</orcidid><orcidid>https://orcid.org/0000-0002-3499-1477</orcidid><orcidid>https://orcid.org/0000-0001-5957-391X</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2769974980 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Aged Aging Aging - physiology Aorta Augmentation Biology and Life Sciences Blood circulation disorders Blood Pressure Body mass index Caffeine Cardiovascular disease Carotid arteries Carotid Intima-Media Thickness Correlation Diabetes Diagnosis Electrocardiography Exercise Female Health aspects Humans Hypertension Male Measurement Mechanical properties Medicine and Health Sciences Metabolic disorders Middle Aged Modulus of elasticity Mortality Physical Sciences Physiology Pulse Pulse Wave Analysis Risk Factors Sensitivity Stiffness Thickness Ultrasonic imaging Validation studies Validity Vascular Stiffness - physiology Veins & arteries Velocity Wave velocity |
| title | Estimated pulse wave velocity as a measure of vascular aging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T08%3A13%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimated%20pulse%20wave%20velocity%20as%20a%20measure%20of%20vascular%20aging&rft.jtitle=PloS%20one&rft.au=Heffernan,%20Kevin%20S&rft.date=2023-01-26&rft.volume=18&rft.issue=1&rft.spage=e0280896&rft.epage=e0280896&rft.pages=e0280896-e0280896&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0280896&rft_dat=%3Cgale_plos_%3EA734767706%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2769974980&rft_id=info:pmid/36701358&rft_galeid=A734767706&rft_doaj_id=oai_doaj_org_article_990213e0161942d38d66e12f5b57c0f9&rfr_iscdi=true |