Different CprABC amino acid sequences affect nisin A susceptibility in Clostridioides difficile isolates

Clinical isolates of Clostridioides difficile sometimes exhibit multidrug resistance and cause diarrhea after antibiotic administration. Metronidazole and vancomycin are often used as therapeutic agents, but resistance to these antibiotics has been found clinically. Therefore, the development of alt...

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Veröffentlicht in:	PloS one 2023-01, Vol.18 (1), p.e0280676-e0280676
Hauptverfasser:	Ide, Noriaki, Kawada-Matsuo, Miki, Le, Mi Nguyen-Tra, Hisatsune, Junzo, Nishi, Hiromi, Hara, Toshinori, Kitamura, Norikazu, Kashiyama, Seiya, Yokozaki, Michiya, Kawaguchi, Hiroyuki, Ohge, Hiroki, Sugai, Motoyuki, Komatsuzawa, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Anti-Bacterial Agents - pharmacology Antibiotics Antiinfectives and antibacterials Antimicrobial agents Bacteria Bacteriocins Biology and Life Sciences Biosynthesis Cell surface Chemical compounds Clinical isolates Clostridioides Clostridioides difficile Clostridium Infections Clusters Computer and Information Sciences Cytochrome Cytochrome c Cytochromes Diarrhea Drug resistance Efflux Epidemiology Gene expression Genomes Gram-negative bacteria Gram-positive bacteria Health aspects Humans Medicine and Health Sciences Metronidazole Microbial Sensitivity Tests Multidrug resistance Nisin Nisin - pharmacology Nucleotide sequence Peptides Pharmacology Phylogenetics Phylogeny Research and Analysis Methods Strains (organisms) Streptococcus infections Surface charge Susceptibility Vancomycin
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