Occurrence, fate, and risk assessment of antibiotics in typical pharmaceutical manufactories and receiving water bodies from different regions
This study aimed to investigate the presence and persistence of antibiotics in wastewater of four typical pharmaceutical manufactories in China and receiving water bodies and suggest the removal of antibiotics by the wastewater treatment process. It also evaluated the environmental impact of antibio...
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| Veröffentlicht in: | PloS one 2023-01, Vol.18 (1), p.e0270945 |
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| creator | Liu, Yuanfei Cai, Dan Li, Xin Wu, Qingyao Ding, Ping Shen, Liangchen Yang, Jian Hu, Guocheng Wu, Jinhua Zhang, Lijuan |
| description | This study aimed to investigate the presence and persistence of antibiotics in wastewater of four typical pharmaceutical manufactories in China and receiving water bodies and suggest the removal of antibiotics by the wastewater treatment process. It also evaluated the environmental impact of antibiotic residues through wastewater discharge into receiving water bodies. The results indicated that thirteen antibiotics were detected in wastewater samples with concentrations ranging from 57.03 to 726.79 ng/L. Fluoroquinolones and macrolides were the most abundant antibiotic classes found in wastewater samples, accounting for 42.5% and 38.7% of total antibiotic concentrations, respectively, followed by sulfonamides (16.4%) and tetracyclines (2.4%). Erythromycin-H2O, lincomycin, ofloxacin, and trimethoprim were the most frequently detected antibiotics; among these antibiotics, the concentration of ofloxacin was the highest in most wastewater samples. No significant difference was found in different treatment processes used to remove antibiotics in wastewater samples. More than 50% of antibiotics were not completely removed with a removal efficiency of less than 70%. The concentration of detected antibiotics in the receiving water bodies was an order of magnitude lower than that in the wastewater sample due to dilution. An environmental risk assessment showed that lincomycin and ofloxacin could pose a high risk at the concentrations detected in effluents and a medium risk in their receiving water bodies, highlighting a potential hazard to the health of the aquatic ecosystem. Overall, The investigation was aimed to determine and monitor the concentration of selected antibiotics in 4 typical PMFs and their receiving water bodies, and to study the removal of these substances in PMFs. This study will provide significant data and findings for future studies on antibiotics-related pollution control and management in water bodies. |
| doi_str_mv | 10.1371/journal.pone.0270945 |
| format | Article |
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It also evaluated the environmental impact of antibiotic residues through wastewater discharge into receiving water bodies. The results indicated that thirteen antibiotics were detected in wastewater samples with concentrations ranging from 57.03 to 726.79 ng/L. Fluoroquinolones and macrolides were the most abundant antibiotic classes found in wastewater samples, accounting for 42.5% and 38.7% of total antibiotic concentrations, respectively, followed by sulfonamides (16.4%) and tetracyclines (2.4%). Erythromycin-H2O, lincomycin, ofloxacin, and trimethoprim were the most frequently detected antibiotics; among these antibiotics, the concentration of ofloxacin was the highest in most wastewater samples. No significant difference was found in different treatment processes used to remove antibiotics in wastewater samples. More than 50% of antibiotics were not completely removed with a removal efficiency of less than 70%. The concentration of detected antibiotics in the receiving water bodies was an order of magnitude lower than that in the wastewater sample due to dilution. An environmental risk assessment showed that lincomycin and ofloxacin could pose a high risk at the concentrations detected in effluents and a medium risk in their receiving water bodies, highlighting a potential hazard to the health of the aquatic ecosystem. Overall, The investigation was aimed to determine and monitor the concentration of selected antibiotics in 4 typical PMFs and their receiving water bodies, and to study the removal of these substances in PMFs. This study will provide significant data and findings for future studies on antibiotics-related pollution control and management in water bodies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0270945</identifier><identifier>PMID: 36662697</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anti-Bacterial Agents - analysis ; Antibiotics ; Aquatic ecosystems ; Biology and Life Sciences ; China ; Chromatography ; Composition ; Dilution ; Drug resistance ; Earth Sciences ; Ecology and Environmental Sciences ; Ecosystem ; Effluents ; Engineering and Technology ; Environmental assessment ; Environmental impact ; Environmental Monitoring ; Environmental risk ; Erythromycin ; Fluoroquinolones ; Health risks ; Lincomycin ; Medicine and Health Sciences ; Methods ; Ofloxacin ; Pharmaceutical industry ; Pharmaceutical Preparations ; Pharmaceuticals ; Pollution control ; Purification ; R&D ; Receiving waters ; Research & development ; Risk Assessment ; Rivers ; Sewage ; Sulfonamides ; Surface water ; Tetracyclines ; Trimethoprim ; Waste Disposal, Fluid ; Wastewater ; Wastewater dilution ; Wastewater discharges ; Wastewater treatment ; Water ; Water discharge ; Water Pollutants, Chemical - analysis ; Water pollution ; Water sampling ; Water treatment</subject><ispartof>PloS one, 2023-01, Vol.18 (1), p.e0270945</ispartof><rights>Copyright: © 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Liu et al 2023 Liu et al</rights><rights>2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-bccfd6e45fb9e80e7f8889e443ebf05245d082c995552cc2ebe95948284e374e3</citedby><cites>FETCH-LOGICAL-c692t-bccfd6e45fb9e80e7f8889e443ebf05245d082c995552cc2ebe95948284e374e3</cites><orcidid>0000-0003-2137-459X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858356/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858356/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36662697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yuanfei</creatorcontrib><creatorcontrib>Cai, Dan</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Wu, Qingyao</creatorcontrib><creatorcontrib>Ding, Ping</creatorcontrib><creatorcontrib>Shen, Liangchen</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Hu, Guocheng</creatorcontrib><creatorcontrib>Wu, Jinhua</creatorcontrib><creatorcontrib>Zhang, Lijuan</creatorcontrib><title>Occurrence, fate, and risk assessment of antibiotics in typical pharmaceutical manufactories and receiving water bodies from different regions</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to investigate the presence and persistence of antibiotics in wastewater of four typical pharmaceutical manufactories in China and receiving water bodies and suggest the removal of antibiotics by the wastewater treatment process. It also evaluated the environmental impact of antibiotic residues through wastewater discharge into receiving water bodies. The results indicated that thirteen antibiotics were detected in wastewater samples with concentrations ranging from 57.03 to 726.79 ng/L. Fluoroquinolones and macrolides were the most abundant antibiotic classes found in wastewater samples, accounting for 42.5% and 38.7% of total antibiotic concentrations, respectively, followed by sulfonamides (16.4%) and tetracyclines (2.4%). Erythromycin-H2O, lincomycin, ofloxacin, and trimethoprim were the most frequently detected antibiotics; among these antibiotics, the concentration of ofloxacin was the highest in most wastewater samples. No significant difference was found in different treatment processes used to remove antibiotics in wastewater samples. More than 50% of antibiotics were not completely removed with a removal efficiency of less than 70%. The concentration of detected antibiotics in the receiving water bodies was an order of magnitude lower than that in the wastewater sample due to dilution. An environmental risk assessment showed that lincomycin and ofloxacin could pose a high risk at the concentrations detected in effluents and a medium risk in their receiving water bodies, highlighting a potential hazard to the health of the aquatic ecosystem. Overall, The investigation was aimed to determine and monitor the concentration of selected antibiotics in 4 typical PMFs and their receiving water bodies, and to study the removal of these substances in PMFs. This study will provide significant data and findings for future studies on antibiotics-related pollution control and management in water bodies.</description><subject>Anti-Bacterial Agents - analysis</subject><subject>Antibiotics</subject><subject>Aquatic ecosystems</subject><subject>Biology and Life Sciences</subject><subject>China</subject><subject>Chromatography</subject><subject>Composition</subject><subject>Dilution</subject><subject>Drug resistance</subject><subject>Earth Sciences</subject><subject>Ecology and Environmental Sciences</subject><subject>Ecosystem</subject><subject>Effluents</subject><subject>Engineering and Technology</subject><subject>Environmental assessment</subject><subject>Environmental impact</subject><subject>Environmental Monitoring</subject><subject>Environmental risk</subject><subject>Erythromycin</subject><subject>Fluoroquinolones</subject><subject>Health risks</subject><subject>Lincomycin</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Ofloxacin</subject><subject>Pharmaceutical industry</subject><subject>Pharmaceutical Preparations</subject><subject>Pharmaceuticals</subject><subject>Pollution control</subject><subject>Purification</subject><subject>R&D</subject><subject>Receiving waters</subject><subject>Research & development</subject><subject>Risk Assessment</subject><subject>Rivers</subject><subject>Sewage</subject><subject>Sulfonamides</subject><subject>Surface water</subject><subject>Tetracyclines</subject><subject>Trimethoprim</subject><subject>Waste Disposal, Fluid</subject><subject>Wastewater</subject><subject>Wastewater dilution</subject><subject>Wastewater discharges</subject><subject>Wastewater treatment</subject><subject>Water</subject><subject>Water discharge</subject><subject>Water Pollutants, Chemical - 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It also evaluated the environmental impact of antibiotic residues through wastewater discharge into receiving water bodies. The results indicated that thirteen antibiotics were detected in wastewater samples with concentrations ranging from 57.03 to 726.79 ng/L. Fluoroquinolones and macrolides were the most abundant antibiotic classes found in wastewater samples, accounting for 42.5% and 38.7% of total antibiotic concentrations, respectively, followed by sulfonamides (16.4%) and tetracyclines (2.4%). Erythromycin-H2O, lincomycin, ofloxacin, and trimethoprim were the most frequently detected antibiotics; among these antibiotics, the concentration of ofloxacin was the highest in most wastewater samples. No significant difference was found in different treatment processes used to remove antibiotics in wastewater samples. More than 50% of antibiotics were not completely removed with a removal efficiency of less than 70%. The concentration of detected antibiotics in the receiving water bodies was an order of magnitude lower than that in the wastewater sample due to dilution. An environmental risk assessment showed that lincomycin and ofloxacin could pose a high risk at the concentrations detected in effluents and a medium risk in their receiving water bodies, highlighting a potential hazard to the health of the aquatic ecosystem. Overall, The investigation was aimed to determine and monitor the concentration of selected antibiotics in 4 typical PMFs and their receiving water bodies, and to study the removal of these substances in PMFs. This study will provide significant data and findings for future studies on antibiotics-related pollution control and management in water bodies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36662697</pmid><doi>10.1371/journal.pone.0270945</doi><tpages>e0270945</tpages><orcidid>https://orcid.org/0000-0003-2137-459X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anti-Bacterial Agents - analysis Antibiotics Aquatic ecosystems Biology and Life Sciences China Chromatography Composition Dilution Drug resistance Earth Sciences Ecology and Environmental Sciences Ecosystem Effluents Engineering and Technology Environmental assessment Environmental impact Environmental Monitoring Environmental risk Erythromycin Fluoroquinolones Health risks Lincomycin Medicine and Health Sciences Methods Ofloxacin Pharmaceutical industry Pharmaceutical Preparations Pharmaceuticals Pollution control Purification R&D Receiving waters Research & development Risk Assessment Rivers Sewage Sulfonamides Surface water Tetracyclines Trimethoprim Waste Disposal, Fluid Wastewater Wastewater dilution Wastewater discharges Wastewater treatment Water Water discharge Water Pollutants, Chemical - analysis Water pollution Water sampling Water treatment |
| title | Occurrence, fate, and risk assessment of antibiotics in typical pharmaceutical manufactories and receiving water bodies from different regions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T13%3A21%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Occurrence,%20fate,%20and%20risk%20assessment%20of%20antibiotics%20in%20typical%20pharmaceutical%20manufactories%20and%20receiving%20water%20bodies%20from%20different%20regions&rft.jtitle=PloS%20one&rft.au=Liu,%20Yuanfei&rft.date=2023-01-20&rft.volume=18&rft.issue=1&rft.spage=e0270945&rft.pages=e0270945-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0270945&rft_dat=%3Cgale_plos_%3EA733942846%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2767425016&rft_id=info:pmid/36662697&rft_galeid=A733942846&rft_doaj_id=oai_doaj_org_article_a1ae6328344547df983ad53b344b6ee9&rfr_iscdi=true |