The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation

Protein tyrosine phosphatase PTP1B is considered as a key metabolic enzyme that has been reported to be associated with insulin resistance onset, and underlying cellular metabolic malfunctions, including ER stress and mitochondrial failure. In this study, effects of selective PTP1B inhibition using...

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Veröffentlicht in:	PloS one 2023-01, Vol.18 (1), p.e0278566-e0278566
Hauptverfasser:	Bourebaba, Lynda, Komakula, Sai Santosh Babu, Weiss, Christine, Adrar, Nabil, Marycz, Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biology and Life Sciences Cell culture Cell Line Cell viability Cellular signal transduction Diabetes mellitus Drug therapy Endoplasmic reticulum Endoplasmic Reticulum Stress Enzyme inhibitors Enzymes Gene expression Health aspects Hepatocellular carcinoma Homeostasis Humans Insulin Insulin resistance Liver Liver cancer Lymphoma Medicine and Health Sciences Membrane potential Metabolic diseases Metabolic disorders Metabolites Mitigation Mitochondria Obesity Oxidative stress Pharmacology, Experimental Phosphatase Phosphatases Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Protein-tyrosine-phosphatase Proteins Reactive Oxygen Species - pharmacology RNA Splicing Signal Transduction Stress (Physiology) Testing Tunicamycin Tunicamycin - pharmacology Tyrosine X-Box Binding Protein 1 - genetics
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