Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism

Growth differentiation factor 9 (GDF9) was the first oocyte-specific growth factor identified; however, most information about GDF9 functions comes from studies in the mouse model. In this study, we created a mutant for Gdf9 gene (gdf9-/-) in zebrafish using TALEN approach. The loss of Gdf9 caused a...

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Veröffentlicht in:	PLoS genetics 2022-12, Vol.18 (12), p.e1010318
Hauptverfasser:	Chen, Weiting, Zhai, Yue, Zhu, Bo, Wu, Kun, Fan, Yuqin, Zhou, Xianqing, Liu, Lin, Ge, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Activin Activins - genetics Activins - metabolism Amino acids Analysis Animals Biology and Life Sciences Cell activation Danio rerio Engineering and technology Estradiol Estrogens Female Females Fishes Follicles Folliculogenesis Genes Genetic aspects Growth Growth differentiation factor 9 Growth Differentiation Factor 9 - genetics Growth Differentiation Factor 9 - metabolism Health aspects Inhibin Inhibins - genetics Inhibins - metabolism Kinases Laboratories Male Medicine and Health Sciences Mice Mutants Mutation Ovarian Follicle - metabolism Ovaries Phenotypes Phosphorylation Proteins Research and Analysis Methods Roles Sex reversal Signal transduction Transforming growth factors Zebrafish Zebrafish - genetics Zebrafish - metabolism
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