Malnutrition leads to the progression of coronary artery calcification in hemodialysis patients
Malnutrition is considered a risk factor for cardiovascular disease in patients with chronic kidney disease. However, no in vivo studies have reported on using optical coherence tomography to evaluate the effect of nutritional status on coronary atherosclerosis in hemodialysis patients. We aimed to...
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| Veröffentlicht in: | PloS one 2023-01, Vol.18 (1), p.e0280383 |
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| creator | Okabe, Hiroki Muraoka, Yoshitaka Naka, Yutaro Setoyama, Koshi Inoue, Konosuke Miura, Toshiya Shimizu, Akiyoshi Anai, Reo Miyamoto, Tetsu Tsuda, Yuki Araki, Masaru Sonoda, Shinjo Kataoka, Masaharu |
| description | Malnutrition is considered a risk factor for cardiovascular disease in patients with chronic kidney disease. However, no in vivo studies have reported on using optical coherence tomography to evaluate the effect of nutritional status on coronary atherosclerosis in hemodialysis patients. We aimed to conduct a detailed analysis of the effect of nutritional status on the coronary arteries in hemodialysis patients.
Among 64 hemodialysis patients who underwent percutaneous coronary interventions, 41 that underwent optical coherence tomography imaging were included in this study. And, among them, 24 patients that could also be evaluated using OCT also at the 6-month follow-up were included in this study. The patients were divided into two groups based on nutritional evaluation using the geriatric nutritional risk index. Culprit and non-culprit lesions were evaluated at baseline and after 6 months.
In the culprit lesions at baseline, the length of the lipid plaque was significantly smaller in the malnutrition group. In contrast, the thickness and length of the calcified plaque and the angle of the calcified nodule were significantly larger (each p < 0.01). In the non-culprit lesions, the 6-month change in the angle of the calcified plaque was significantly greater in the malnutrition group (p = 0.02). The significant factors that affected the change in the angle of calcification were "malnutrition at geriatric nutritional risk index" [odds ratio, 8.17; 95% confidence interval, 1.79 to 37.33; p < 0.01] and "serum phosphorus level" (odds ratio, 3.73; 95% confidence interval, 1.42 to 9.81; p < 0.01).
Appropriate management of nutritional status is crucial for suppressing the progression of coronary artery disease in hemodialysis patients. |
| doi_str_mv | 10.1371/journal.pone.0280383 |
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Among 64 hemodialysis patients who underwent percutaneous coronary interventions, 41 that underwent optical coherence tomography imaging were included in this study. And, among them, 24 patients that could also be evaluated using OCT also at the 6-month follow-up were included in this study. The patients were divided into two groups based on nutritional evaluation using the geriatric nutritional risk index. Culprit and non-culprit lesions were evaluated at baseline and after 6 months.
In the culprit lesions at baseline, the length of the lipid plaque was significantly smaller in the malnutrition group. In contrast, the thickness and length of the calcified plaque and the angle of the calcified nodule were significantly larger (each p < 0.01). In the non-culprit lesions, the 6-month change in the angle of the calcified plaque was significantly greater in the malnutrition group (p = 0.02). The significant factors that affected the change in the angle of calcification were "malnutrition at geriatric nutritional risk index" [odds ratio, 8.17; 95% confidence interval, 1.79 to 37.33; p < 0.01] and "serum phosphorus level" (odds ratio, 3.73; 95% confidence interval, 1.42 to 9.81; p < 0.01).
Appropriate management of nutritional status is crucial for suppressing the progression of coronary artery disease in hemodialysis patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0280383</identifier><identifier>PMID: 36638132</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Angioplasty ; Arteries ; Arteriosclerosis ; Atherosclerosis ; Biology and Life Sciences ; Blood pressure ; Calcification ; Calcification (ectopic) ; Cardiovascular disease ; Cardiovascular diseases ; Catheters ; Complications and side effects ; Coronary Angiography ; Coronary artery disease ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnostic imaging ; Coronary heart disease ; Coronary vessels ; Coronary Vessels - diagnostic imaging ; Development and progression ; Diabetes ; Health risks ; Heart diseases ; Hemodialysis ; Humans ; In vivo methods and tests ; Kidney diseases ; Lesions ; Lipids ; Malnutrition ; Malnutrition - complications ; Mann-Whitney U test ; Medical imaging ; Medical prognosis ; Medicine and Health Sciences ; Metabolism ; Nutrition assessment ; Nutritional status ; Optical Coherence Tomography ; Patients ; Percutaneous Coronary Intervention ; Phosphorus ; Plaque, Atherosclerotic ; Renal Dialysis - adverse effects ; Research and Analysis Methods ; Retrospective Studies ; Risk analysis ; Risk factors ; Stents ; Tomography ; Tomography, Optical Coherence - methods ; Vascular Calcification - etiology</subject><ispartof>PloS one, 2023-01, Vol.18 (1), p.e0280383</ispartof><rights>Copyright: © 2023 Okabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Okabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Okabe et al 2023 Okabe et al</rights><rights>2023 Okabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4f76b7df0c2e482fa12ee5162723f573e032ac1e72b812ecfb92d86d87739bff3</citedby><cites>FETCH-LOGICAL-c692t-4f76b7df0c2e482fa12ee5162723f573e032ac1e72b812ecfb92d86d87739bff3</cites><orcidid>0000-0002-9557-6082 ; 0000-0003-4879-8245 ; 0000-0001-8034-1005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838858/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838858/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36638132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ranjan, Redoy</contributor><creatorcontrib>Okabe, Hiroki</creatorcontrib><creatorcontrib>Muraoka, Yoshitaka</creatorcontrib><creatorcontrib>Naka, Yutaro</creatorcontrib><creatorcontrib>Setoyama, Koshi</creatorcontrib><creatorcontrib>Inoue, Konosuke</creatorcontrib><creatorcontrib>Miura, Toshiya</creatorcontrib><creatorcontrib>Shimizu, Akiyoshi</creatorcontrib><creatorcontrib>Anai, Reo</creatorcontrib><creatorcontrib>Miyamoto, Tetsu</creatorcontrib><creatorcontrib>Tsuda, Yuki</creatorcontrib><creatorcontrib>Araki, Masaru</creatorcontrib><creatorcontrib>Sonoda, Shinjo</creatorcontrib><creatorcontrib>Kataoka, Masaharu</creatorcontrib><title>Malnutrition leads to the progression of coronary artery calcification in hemodialysis patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Malnutrition is considered a risk factor for cardiovascular disease in patients with chronic kidney disease. However, no in vivo studies have reported on using optical coherence tomography to evaluate the effect of nutritional status on coronary atherosclerosis in hemodialysis patients. We aimed to conduct a detailed analysis of the effect of nutritional status on the coronary arteries in hemodialysis patients.
Among 64 hemodialysis patients who underwent percutaneous coronary interventions, 41 that underwent optical coherence tomography imaging were included in this study. And, among them, 24 patients that could also be evaluated using OCT also at the 6-month follow-up were included in this study. The patients were divided into two groups based on nutritional evaluation using the geriatric nutritional risk index. Culprit and non-culprit lesions were evaluated at baseline and after 6 months.
In the culprit lesions at baseline, the length of the lipid plaque was significantly smaller in the malnutrition group. In contrast, the thickness and length of the calcified plaque and the angle of the calcified nodule were significantly larger (each p < 0.01). In the non-culprit lesions, the 6-month change in the angle of the calcified plaque was significantly greater in the malnutrition group (p = 0.02). The significant factors that affected the change in the angle of calcification were "malnutrition at geriatric nutritional risk index" [odds ratio, 8.17; 95% confidence interval, 1.79 to 37.33; p < 0.01] and "serum phosphorus level" (odds ratio, 3.73; 95% confidence interval, 1.42 to 9.81; p < 0.01).
Appropriate management of nutritional status is crucial for suppressing the progression of coronary artery disease in hemodialysis patients.</description><subject>Aged</subject><subject>Angioplasty</subject><subject>Arteries</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Catheters</subject><subject>Complications and side effects</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Kidney diseases</subject><subject>Lesions</subject><subject>Lipids</subject><subject>Malnutrition</subject><subject>Malnutrition - complications</subject><subject>Mann-Whitney U test</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Nutrition assessment</subject><subject>Nutritional status</subject><subject>Optical Coherence Tomography</subject><subject>Patients</subject><subject>Percutaneous Coronary Intervention</subject><subject>Phosphorus</subject><subject>Plaque, Atherosclerotic</subject><subject>Renal Dialysis - adverse effects</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Stents</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Vascular Calcification - 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leads to the progression of coronary artery calcification in hemodialysis patients</title><author>Okabe, Hiroki ; Muraoka, Yoshitaka ; Naka, Yutaro ; Setoyama, Koshi ; Inoue, Konosuke ; Miura, Toshiya ; Shimizu, Akiyoshi ; Anai, Reo ; Miyamoto, Tetsu ; Tsuda, Yuki ; Araki, Masaru ; Sonoda, Shinjo ; Kataoka, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4f76b7df0c2e482fa12ee5162723f573e032ac1e72b812ecfb92d86d87739bff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Angioplasty</topic><topic>Arteries</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Catheters</topic><topic>Complications and side 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Toshiya</au><au>Shimizu, Akiyoshi</au><au>Anai, Reo</au><au>Miyamoto, Tetsu</au><au>Tsuda, Yuki</au><au>Araki, Masaru</au><au>Sonoda, Shinjo</au><au>Kataoka, Masaharu</au><au>Ranjan, Redoy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malnutrition leads to the progression of coronary artery calcification in hemodialysis patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-01-13</date><risdate>2023</risdate><volume>18</volume><issue>1</issue><spage>e0280383</spage><pages>e0280383-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Malnutrition is considered a risk factor for cardiovascular disease in patients with chronic kidney disease. However, no in vivo studies have reported on using optical coherence tomography to evaluate the effect of nutritional status on coronary atherosclerosis in hemodialysis patients. We aimed to conduct a detailed analysis of the effect of nutritional status on the coronary arteries in hemodialysis patients.
Among 64 hemodialysis patients who underwent percutaneous coronary interventions, 41 that underwent optical coherence tomography imaging were included in this study. And, among them, 24 patients that could also be evaluated using OCT also at the 6-month follow-up were included in this study. The patients were divided into two groups based on nutritional evaluation using the geriatric nutritional risk index. Culprit and non-culprit lesions were evaluated at baseline and after 6 months.
In the culprit lesions at baseline, the length of the lipid plaque was significantly smaller in the malnutrition group. In contrast, the thickness and length of the calcified plaque and the angle of the calcified nodule were significantly larger (each p < 0.01). In the non-culprit lesions, the 6-month change in the angle of the calcified plaque was significantly greater in the malnutrition group (p = 0.02). The significant factors that affected the change in the angle of calcification were "malnutrition at geriatric nutritional risk index" [odds ratio, 8.17; 95% confidence interval, 1.79 to 37.33; p < 0.01] and "serum phosphorus level" (odds ratio, 3.73; 95% confidence interval, 1.42 to 9.81; p < 0.01).
Appropriate management of nutritional status is crucial for suppressing the progression of coronary artery disease in hemodialysis patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36638132</pmid><doi>10.1371/journal.pone.0280383</doi><tpages>e0280383</tpages><orcidid>https://orcid.org/0000-0002-9557-6082</orcidid><orcidid>https://orcid.org/0000-0003-4879-8245</orcidid><orcidid>https://orcid.org/0000-0001-8034-1005</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2023-01, Vol.18 (1), p.e0280383 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2765305437 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Angioplasty Arteries Arteriosclerosis Atherosclerosis Biology and Life Sciences Blood pressure Calcification Calcification (ectopic) Cardiovascular disease Cardiovascular diseases Catheters Complications and side effects Coronary Angiography Coronary artery disease Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary heart disease Coronary vessels Coronary Vessels - diagnostic imaging Development and progression Diabetes Health risks Heart diseases Hemodialysis Humans In vivo methods and tests Kidney diseases Lesions Lipids Malnutrition Malnutrition - complications Mann-Whitney U test Medical imaging Medical prognosis Medicine and Health Sciences Metabolism Nutrition assessment Nutritional status Optical Coherence Tomography Patients Percutaneous Coronary Intervention Phosphorus Plaque, Atherosclerotic Renal Dialysis - adverse effects Research and Analysis Methods Retrospective Studies Risk analysis Risk factors Stents Tomography Tomography, Optical Coherence - methods Vascular Calcification - etiology |
| title | Malnutrition leads to the progression of coronary artery calcification in hemodialysis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T06%3A32%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Malnutrition%20leads%20to%20the%20progression%20of%20coronary%20artery%20calcification%20in%20hemodialysis%20patients&rft.jtitle=PloS%20one&rft.au=Okabe,%20Hiroki&rft.date=2023-01-13&rft.volume=18&rft.issue=1&rft.spage=e0280383&rft.pages=e0280383-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0280383&rft_dat=%3Cgale_plos_%3EA733188447%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2765305437&rft_id=info:pmid/36638132&rft_galeid=A733188447&rft_doaj_id=oai_doaj_org_article_d650dd927d544f93a0875acf53971e08&rfr_iscdi=true |